bromocriptine

[210toosmall]

Bromocriptine is also used to treat acromegaly (overproduction of growth hormone) and pituitary prolactinomas (tumors of the pituitary gland).

if this statement is true could tren cause tumors in pituitary gland?

plz no flames its an honest ?

 

[210toosmall]

shit! upon further inspection its (bromo) used to treat high gh production?
does that mean it can decrease normal production?

that sucks!

 

[roidpuple]

How does it work?

Bromocriptine is a type of medicine called a dopamine agonist. It works by stimulating dopamine receptors in the brain. This can have several results, hence the medicine has several different uses.

Bromocriptine is mainly used to treat disorders that result from high levels of the hormone prolactin in the blood. Prolactin is produced by the pituitary gland in the brain. Bromocriptine decreases the production of prolactin from the pituitary by stimulating dopamine receptors.

A high prolactin level is associated with several conditions. Over-production of this hormone can cause abnormal production of breast milk in both men and women (galactorrhoea), as well as suppression of the sexual glands (hypogonadism), which can result in infertility. High prolactin levels are also associated with some breast and menstrual disorders. Reducing prolactin levels with bromocriptine can therefore improve these conditions.

Bromocriptine is also sometimes used to prevent or stop milk production for medical reasons following childbirth, miscarriage or abortion. Prolactin is the hormone that stimulates the production of breast milk, hence decreasing the production of prolactin with bromocriptine stops milk production.

A further use of bromocriptine is to reduce prolactin production from a type of tumour of the pituitary gland, called a prolactinoma.

Bromocriptine's action on dopamine receptors also decreases the production of growth hormone from the pituitary gland. This is useful for treating conditions where growth hormone is overproduced, such as acromegaly.

Lastly, bromocriptine can be used to treat Parkinson's disease. The neurotransmitter dopamine is known to be reduced or absent in the brains of people with Parkinson's disease, and this is thought to be the cause of the disease symptoms. Stimulating dopamine receptors with bromocriptine is similar to replacing the dopamine in the brain, and this reduces some of the symptoms of Parkinson's disease.



What is it used for?



High prolactin levels that have caused suppression of the sexual glands (leading to infertility) and/or abnormal milk production in men or women


Preventing or stopping milk production (lactation) for medical reasons following childbirth, miscarriage or abortion


Benign breast disease or breast pain that occurs at certain times of the menstrual cycle


Menstrual cycle disorders and premenstrual symptoms, eg headaches, breast pain, mood changes or bloating


Infertility


Benign tumours in the pituitary gland that release prolactin (prolactinomas)


Excess growth hormone production resulting in enlarged facial features, hands and feet (acromegaly)


Parkinson's disease

I LOVE KARMA !!!

 

[roidpuple]

Effect of bromocriptine on thyroid hormone-induced growth hormone production in cultured GH1 cells.

Tsai JS, Pasqual A.

L-triiodothyronine induces a three-fold increase in growth hormone production in cultured GH1 cells. The dopaminergic agonist, bromocriptine, inhibits the thyroid hormone-induced growth hormone production to the level of that produced by the control cells. This effect can be observed within eight hours of incubation and persists as long as forty-eight hours in culture and is not due to a change in cell population. In contrast, bromocriptine appears to have no effect on growth hormone production in the control cultures. The estimated concentration of bromocriptine which gives a half-maximal inhibitory effect is 0.3 nM, and concentrations above 5 nM give a complete inhibitory effect. The intracellular growth hormone concentration represents only a very small fraction of total hormone production and does not appear to be influenced by bromocriptine. Therefore, the inhibitory effect of bromocriptine on growth hormone production in thyroid hormone treated cultured GH1 cells may result from its action on the synthesis of growth hormone.


I LOVE KARMA !!!

 

[210toosmall]

Effect of bromocriptine on thyroid hormone-induced growth hormone production in cultured GH1 cells.

Tsai JS, Pasqual A.

L-triiodothyronine induces a three-fold increase in growth hormone production in cultured GH1 cells. The dopaminergic agonist, bromocriptine, inhibits the thyroid hormone-induced growth hormone production to the level of that produced by the control cells. This effect can be observed within eight hours of incubation and persists as long as forty-eight hours in culture and is not due to a change in cell population. In contrast, bromocriptine appears to have no effect on growth hormone production in the control cultures. The estimated concentration of bromocriptine which gives a half-maximal inhibitory effect is 0.3 nM, and concentrations above 5 nM give a complete inhibitory effect. The intracellular growth hormone concentration represents only a very small fraction of total hormone production and does not appear to be influenced by bromocriptine. Therefore, the inhibitory effect of bromocriptine on growth hormone production in thyroid hormone treated cultured GH1 cells may result from its action on the synthesis of growth hormone.


I LOVE KARMA !!!

good lookin' out k to ya (i think i can)