Try a few of these lol. Most prove that IGF-1 and GH DO indeed have increased localized effects on the tissues, muscles included, where they are injected. And as we all should know, most steroids, like nandrolone, trenbolone, etc, increase IGF-1 levels. I hate to prove you wrong bro, but it's right there in black and white. Sure, it doesn't work very well for most people, sure it CAN screw you up if you do it like Greg Valentino, but does localized injection work via IGF-1, GH, fascia-stretching, etc? Hell yes, and the medical evidence proves it. Deny it now.
Regulation and action of insulin-like growth factors at the cellular level
L S Phillips, J B Harp, S Goldstein, C I Pao
Proceedings of the Nutrition Society , 49(3):451-458 1990
Present understanding of IGF-1 as a growth factor mediating integration of nutritional-hormonal interactions indicates that IGF-1 acts in both an endocrine mode on distant targets and an autocrine-paracrine mode on local targets. In the liver, the combined presence of GH, insulin, and critical metabolic fuels such as essential amino acids results in increased levels of IGF-1 messenger RNA, increased production of a high-MW IGF-1 precursor, and increased release of IGF-1 into the circulation, permitting action on distant target tissues bearing specific receptors for IGF-1. The net effect is distant amplification of anabolic hormone action via IGF-1 acting in an endocrine mode. In extrahepatic tissues, both 'general' anabolic hormones (insulin and GH) as well as 'specific' hormones (e.g. gonadotropins) acting on a wide variety of targets (including fibroblasts and chondrocytes as well as granulosa and Leydig cells) promote both local secretion of IGF-1 and an increase in IGF-1 receptors. Local actions of IGF-1 then result in a secondary increase in both hormone receptors and hormone responses. The net effect is local amplification of hormone action via IGF-1 acting as a growth factor in an autocrine-paracrine mode.
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