Given Nicotine’s pharmacology, it appears to be most useful during periods of intense dieting. By enhancing the actions of dopamine, serotonin and leptin, as well as partially inhibiting the actions of neuropeptide Y, nicotine can partially deceive the body into thinking it is fed—thereby decreasing appetite, mobilizing fat, and preserving lean body mass—even in the presence of a calorie deficit.
So, how would one ideally use nicotine while dieting? From our review of the literature, we know that higher doses are more effective than lower doses at regulating various factors such as neuropeptide Y. However, given that these values are based on mg/kg in rats, establishing conversion rates for optimal human usage is a little tricky. Nonetheless, if we return to our original observation that smokers generally weigh less than non-smokers, and suppose that a “smoker” uses approximately 20mg of nicotine a day (about 20 cigarettes, one pack), we can conclude that 20mg might be an appropriate dosage.
It should also be noted that there are a number of other compounds that might compliment a nicotine regimen. Already mentioned has been deprenyl (5-10mg a day), the use of which is aimed at potentiatiating dopaminergic activity. Similarly, caffeine can sensitize the dopaminergic response to nicotine. Because nicotine upregulates tyrosine hydroxylase while concurrently inducing catecholamine release, supplementing with L-tyrosine would ensure ample substrates for neurotransmitter formation. Finally, Spook suggested the addition of calcium supplements, as nicotine induces the release of calcitonin gene-related peptide (CGRP), which can deplete intracellular calcium stores.