yes, You should take it from the beginning of the cycle.. Test is going to aromatize in the body... Anything that will raise your test is going to raise estrogen levels leaving your susceptible to gyno... especially 750mg per week..... i would go with anastrozole .5mg ED... should help or formastanzol 8-10 pumps per day.... The only thing about arimidex is when your done using it, your levels can go back up... So make sure you have a good serm and your pct in check bro..