aromasin dosage ?

[lawnsaver]

I have been using aromasin for almost a year now. I am prone to gyno. I notice slight gyno arising even while taking 25mg of aromasin ed. I was only using 700mg of test/week too. I know without a doubt my stuff is real. - cbeaks

This goes to show that individual estrogen sensitivity is the key. We must find out what are limits are. I am not prone to gyno, so I would need to take as much. It is an individual thing as with all substances.

 

[CanadianBro]

It is an individual thing as with all substances.

As far as Aromasin is concerned, I have NEVER seen an athlete have any signs of gyno due to estrogen conversion through the aromatase enzyme when using Aromasin.

When this occurs, it is usually due to another substance within the cycle. Possibly Deca or Fina.

 

[hhajdo]

Whats the half life of aromasin folks?

.....Pharmacokinetics
Following oral administration to healthy postmenopausal women, exemestane is rapidly absorbed. After
maximum plasma concentration is reached, levels decline polyexponentially with a mean terminal halflife
of about 24 hours......

 

[cbeaks]

Were you taking anything else with the Test.

Yeah, actually my last cycle was 500mg of test/week and 150mg of tren eod. I guess it could have been the fina. - cbeaks

 

[lawnsaver]

.....Pharmacokinetics
Following oral administration to healthy postmenopausal women, exemestane is rapidly absorbed. After
maximum plasma concentration is reached, levels decline polyexponentially with a mean terminal halflife
of about 24 hours......

Then why does its effects last so long?? I am not questioning the halflife, but the actions in which it exerts itself so strongly for up to 4-5 days. Valid question!!

Please advise

 

[CanadianBro]

Then why does its effects last so long?? I am not questioning the halflife, but the actions in which it exerts itself so strongly for up to 4-5 days. Valid question!!

Please advise

Excellent question LAWNSAVER.

Here's the reason Exemestane is effective for 4-5 days.

After oral administration, peak levels of Exemestane are reached in the blood at approximately 1.5 hours, and the drug is cleared from the body with a half-life of approximately 3 hours.

However, due to its nature as an irreversible inhibitor, its estrogen-suppressing activity outlives it actual active lifespan in the bloodstream.

Let me say this again...

" due to its nature as an irreversible inhibitor, its estrogen-suppressing activity outlives it actual active lifespan in the bloodstream."

You see, even though the Exemestane is not present in the bloodstream (halflife) it binds to the Aromatase Enzyme UNTIL the body replaces it through the attrition of enzymes. So therefore, it will continue to work as an Aromatase inhibitor UNTIL the enzymes are replaced.

It's half life really has nothing to do with how long it inhibits estrogen due to Exemestane's irreversible nature.

This is another reason I strongly prefer Aromasin over Arimidex.

 

[lawnsaver]

Excellent question LAWNSAVER.

Here's the reason Exemestane is effective for 4-5 days.

After oral administration, peak levels of Exemestane are reached in the blood at approximately 1.5 hours, and the drug is cleared from the body with a half-life of approximately 3 hours.

However, due to its nature as an irreversible inhibitor, its estrogen-suppressing activity outlives it actual active lifespan in the bloodstream.

Let me say this again...

" due to its nature as an irreversible inhibitor, its estrogen-suppressing activity outlives it actual active lifespan in the bloodstream."

You see, even though the Exemestane is not present in the bloodstream (halflife) it binds to the Aromatase Enzyme UNTIL the body replaces it through the attrition of enzymes. So therefore, it will continue to work as an Aromatase inhibitor UNTIL the enzymes are replaced.

It's half life really has nothing to do with how long it inhibits estrogen due to Exemestane's irreversible nature.

This is another reason I strongly prefer Aromasin over Arimidex.

CB, that is exactly what I and everyone wanted to hear! Great answer!

 

[Canuck4]

Great info bro.

Excellent question LAWNSAVER.

Here's the reason Exemestane is effective for 4-5 days.

After oral administration, peak levels of Exemestane are reached in the blood at approximately 1.5 hours, and the drug is cleared from the body with a half-life of approximately 3 hours.

However, due to its nature as an irreversible inhibitor, its estrogen-suppressing activity outlives it actual active lifespan in the bloodstream.

Let me say this again...

" due to its nature as an irreversible inhibitor, its estrogen-suppressing activity outlives it actual active lifespan in the bloodstream."

You see, even though the Exemestane is not present in the bloodstream (halflife) it binds to the Aromatase Enzyme UNTIL the body replaces it through the attrition of enzymes. So therefore, it will continue to work as an Aromatase inhibitor UNTIL the enzymes are replaced.

It's half life really has nothing to do with how long it inhibits estrogen due to Exemestane's irreversible nature.

This is another reason I strongly prefer Aromasin over Arimidex.

 

[CanadianBro]

Thank you Canuck4.

I feel very strongly about the benefits of Aromasin. Especially in high dose cycles. It troubles me to see young, inexperienced athletes develop gyno due to lack of knowledge or misinformation.

 

[jboldman]

I generally concur with the conclusions drawn here, it seems tht aromasin would be the anit-e of choice if one decides to go the anit-aromatase route. I think it should be claified that in healthy men taking exogenous test, it is unlikely that there will be 98% reduction of circulating estrogen since the numbers commonly reported are for post-menopausal women. You should also be aware that not all studies show a reduction of 98%, eg:
"A dose-dependent decrease in serum estrogen level was observed between doses of 0.5 mg and 25 mg. The decrease was maximal at 25 mg, at which serum estrogen concentrations decreased to 14-27% of those observed at day 0. This decrease was maintained for one week, returning to baseline levels 2 weeks after the completion of drug administration. " This demonstrates a significant variability in post menopausal women, it should not be a real stretch of credibility to understand that the end results will depend on the toatal amount of test, the dosing of aromasin, and the total amount of aromatase present.

jb