I copied my post from a similar thread a few months back:
I've ran Adex for years and it works.... but not as good as Aro.
Adex is thought to be a very effective sulfatase/estrone inhibitor. It does an ok job on estradiol. Aro on the other hand is a more potent and effective for E2/estradiol and it's a suicide inhibitor.
For years I thought, who cares if one is slightly better. Adex is cheaper and it's done the job for me all these years, why change. Well, last year I was reading numerous accounts of joint problems, primarily the knees, when using Adex. I always ignored this because I attributed this to simply using too much, thus causing too little estrogen, thus causing joint problems.
It just so happens that I've had knee problems for years. Perhaps as long as I've been using Adex? Hmmmm.
I wondered if there was a correlation. So I switched over to Aro and my knees started to improve. I've always done squats. But they've always been very difficult for me (due to my knees). Since switching AI's, I've been squatting more than ever and my knees feel great.
What's even more interesting, in addition to my knees feeling better, I've kept my E2 lower and better managed gyno flare ups.
Just my 2 cents on Adex and Aro.