Arimidex is an oral aromatase inhibitor manufactured by the Zeneca Pharmaceuticals and approved for use in the United States in 1995s. It is a prescription drug and this means it is a licensed medicine and you need a written prescription from a medical practitioner in order to obtain one.
It is primarily prescribed for adjutant therapy of postmenopausal women with hormone receptor-positive early breast cancer. Adjutant therapy is the treatment given in addition to the patient’s primary treatment (surgery with or without radiation) to prevent cancer cells from multiplying.
Oftentimes, Arimidex is compared to Nolvadex (tamoxifen nitrate) as these two drugs are purposely for the reduction of estrogenic activity in the body to halt or delay the progression of cancer. However, Arimidex is reportedly a more effective drug in combating estrogen-related concerns. This is because as an aromatase inhibitor it blocks the aromatase enzyme, thereby preventing the production of estrogen. Nolvadex, on the other hand, only hinders the action and not the production of this hormone. This is why Arimidex is considered as the second-line defense against breast cancer. When advanced breast cancer has progressed following treatment of Nolvadex, Arimidex is usually prescribed. In cases of advanced breast cancer in postmenopausal women, however, Arimidex is approved for initial use rather than as a second-line defense.
For those male bodybuilders who use steroids, Arimidex can be effective drug in combating excess estrogen. It is usually taken with Nolvadex to ensure estrogen-related side effects are avoided. If used with such drugs as Propecia (finasteride), it results to more ideal outcome. With Arimidex preventing estrogen production and with finasteride preventing testosterone conversion to DHT (dihydrotestosterone), you have an efficient duo in eliminating these hormones’ (estrogen and DHT) undesirable effects, as far as bodybuilding is concerned. Propecia is a specific inhibitor of the 5a-reductase, the enzyme responsible in testosterone conversion to DHT. Propecia reduces the serum concentration of DHT and thereby reduces unwanted androgenic effects like male pattern baldness.
If you’re using highly aromatizable steroids, such as testosterone, you can achieve impressive muscle gains with decreased possibility of water retention and gynecomastia if you stack it with Arimidex and Propecia. The result is a more ripped and defined physique.
It is wrong to think, however, that estrogen and its effects (particularly water and fat retention) are absolutely detrimental to bodybuilding. Remember that this hormone is also responsible for muscle strength and gains. Consequently, it minimizes the occurrence of injury as it improves the ability of muscle fibers to withstand contractile tension or stress. Notice that one of the side effects of Arimidex use (as mentioned below) is the likely occurrence of fractures, a major drawback of this drug. This is because when Arimidex effectively blocks the formation of estrogen, it effectively blocks the benefits of this hormone as well. This is why many still decide for estrogen receptor antagonists like Nolvadex and Clomid because these drugs allow some estrogen activity in the body.
Further, aromatase inhibitors like Arimidex have the tendency to completely suppressed estrogen activity, including its positive effect on cholesterol levels in the body. Arimidex is known to decrease HDL (high-density lipoprotein), or what is commonly known as the ‘good’ cholesterol.
Dosage
Daily dosage for males is from 0.5mg to 3mg. For women, a maximum dosage of 1mg per day is enough to combat estrogenic side effects. Because Arimidex has a short active life, dosages are usually taken two to six times a day at equal intervals. During PCT, athletes normally start with higher dosage then implement a progressive decrease in dosage. The PCT protocol typically runs for seven to 14 days.
In clinical studies, it has been observed that a daily dose of 1 mg of this drug results to more than 80% of estrogen suppression.
Drawbacks
One of the principal drawbacks of this drug is its high cost. A 28-tablet box could cost around $250-280. Recreational bodybuilders would not opt for this drug despite its effectiveness for the simple fact that it is too costly. To their view, an ancillary drug which is overpriced than their staple bodybuilding drugs (steroids) is simply absurd. This market segment tends to look for cheaper alternatives or for generic anastrozole. A generic tab would cost around $2-2.50. The problem with unpatented drugs, however, is that the consumer is not assured of its quality (purity and hygienic concerns). To get around this problem, you can ask around or do some research before opting for such products.
For those who are into competitive bodybuilding, however, price is of no concern. They generally go for Arimidex because it results to more qualitative gains.
In early breast cancer clinical trial, Arimidex side effects include the following: hot flashes, joint symptoms, weakness, mood changes, pain, sore throat, nausea and vomiting, depression, high blood pressure, osteoporosis, swelling of arms/legs, and headache. Fractures (including fractures of the spine, hip, and wrist) occurred more frequently with this drug than with tamoxifen (10% vs 7%).
Arimidex is strongly advised against women who are pregnant or likely to get pregnant since this drug might cause fetal harm.
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Aromasin
is used in the worlds of bodybuilding and professional sports for reducing the level of natural estrogen production by inhibiting the aromatase enzyme, which is responsible for estrogen synthesization. It not only raises the level of testosterone in the body but also reduces the level of estrogen apart from increasing the level of IGF (Insulin-like growth factor).
The unique ability of Aromasin to reduce the levels of estrogen by as much as 85 percent makes it the obvious and first choice in steroid cycles where aromatizing steroids are or to be used. It is also recommended and widely used for long cycles as it is not harsh on the lipid profiles and is hailed as an excellent addition to a PCT (Post-Cycle-Therapy).
Chemical Behavior and Nature
Aromasin, available in oral form, tablets include 25 mg of exemestane, an irreversible and steroidal aromatase inactivator. Exemestane has the chemical formula of 6-methylenandrosta-1,4-diene-3,17-dione and the molecular formula of C20H24O2. It has the molecular weight of 296.41 and each tablet of Aromasin include inactive ingredients such as mannitol, crospovidone, polysorbate 80, hypromellose, sucrose, magnesium carbonate, titanium dioxide, methylparaben, colloidal silicon dioxide, microcrystalline cellulose, sodium starch glycolate, magnesium stearate, simethicone, polyethylene glycol 6000, and polyvinyl alcohol.
Functionality
Aromasin, being an aromatase inhibitor, inhibits the enzyme aromatase that is found in body muscle, breast, fat, and skin to convert androgens into estrogen. Tumors dependent on this hormone start shrinking in the absence of estrogen.
Recommended dosage of Aromasin
The recommended dosage of Aromasin is one tablet of 10-25 mg after a meal for women with early or advanced breast cancer. This dosage works out equally well for sportsmen and bodybuilders looking to reduce the level of estrogen in their bodies.
Tips and Precautions
Aromasin tablets must not be taken by pregnant or expecting women as they can cause damage to the fetus. Moreover, the dosage must not be co-administered with any estrogen-containing agents as it could interfere with its pharmacologic action. In addition to that, the dosage must be in accordance with the qualified medical advice and must be taken ONLY after meals.
Aromasin should not be administered to premenopausal women and is only indicated in postmenopausal women.
Aromasin Abuse
Aromasin abuse can lead to possible side effects like fatigue, hot flashes, bone pain, anxiety, breath shortness, insomnia, and depression.
Storage Conditions
Aromasin tablets are to be kept at a controlled room temperature of 25°C (77°F) with excursions permitted up to 15°–30°C (59°–86°F). They must be kept away from unauthorized usage, pets, children, direct sunlight, heat, and moisture.
Tags: Aromasin, exemestane, breast carcinoma, bodybuilding, testosterone, estrogen, IGF, Insulin-like growth factor, recommended dosage of Aromasin, Aromasin tablets, Aromasin abuse