Re: Any studies/info on high doses of testosterone and anxiety/depression/mood altera
this is a good read:
http://www.nejm.org/doi/full/10.1056/NEJM199607043350101#t=articleResults
RESULTS
The four groups were similar with respect to age and weight, height, and body-mass index before treatment (Table 1TABLE 1
Base-Line Characteristics of the Study Subjects.
). Acne developed in three men receiving testosterone and one receiving placebo, and two men receiving testosterone reported breast tenderness, but no other side effects were noted. The serum liver-enzyme concentrations, hemoglobin concentrations, hematocrits, and red-cell counts did not change in any study group (Table 2TABLE 2
Hemoglobin and Plasma Lipid Concentrations before and after the 10 Weeks of Treatment.
). Serum creatinine concentrations did not change, except in the testosterone-plus-exercise group, in which the mean (±SE) serum creatinine concentration increased from 1.0 mg per deciliter (88 μmol per liter) to 1.1 mg per deciliter (97 μmol per liter) (P=0.02). Plasma concentrations of total and LDL cholesterol and triglycerides did not change in any study group; plasma HDL cholesterol decreased significantly in the placebo-plus-exercise group. There was no change in the serum concentration of prostate-specific antigen in any group.
Endocrine Responses
The base-line serum concentrations of total and free testosterone in the four groups were similar. The serum concentrations of total and free testosterone increased significantly in the two testosterone groups, but not in the placebo groups (Table 3TABLE 3
Serum Concentrations of Endocrine Hormones in the Study Subjects before and after the 10 Weeks of Treatment.
). The base-line serum concentrations of luteinizing hormone, follicle-stimulating hormone, and sex hormone–binding globulin were similar in the four groups, and the concentrations decreased significantly in the two testosterone groups.
Body Weight and Composition
Body weight did not change significantly in the men in either placebo group (Table 4TABLE 4
Body Weight, Fat-free Mass, and Muscle Size and Strength before and after the 10 Weeks of Treatment.
). The men given testosterone without exercise had a significant mean increase in total body weight, and those in the testosterone-plus-exercise group had an average increase of 6.1 kg in body weight — a greater increase than in the other three groups.
Fat-free mass did not change significantly in the group assigned to placebo but no exercise (Table 4 and Figure 1FIGURE 1
Changes from Base Line in Mean (±SE) Fat-free Mass, Triceps and Quadriceps Cross-Sectional Areas, and Muscle Strength in the Bench-Press and Squatting Exercises over the 10 Weeks of Treatment.
). The men treated with testosterone but no exercise had an increase of 3.2 kg in fat-free mass, and those in the placebo-plus-exercise group had an increase of 1.9 kg. The increase in the testosterone-plus-exercise group was substantially greater (averaging 6.1 kg). The percentage of body fat did not change significantly in any group (data not shown).
Muscle Size
The mean cross-sectional areas of the arm and leg muscles did not change significantly in the placebo groups, whether the men had exercise or not (Table 4 and Figure 1). The men in the testosterone groups had significant increases in the cross-sectional areas of the triceps and the quadriceps (Table 4); the group assigned to testosterone without exercise had a significantly greater increase in the cross-sectional area of the quadriceps than the placebo-alone group, and the testosterone-plus-exercise group had greater increases in quadriceps and triceps area than either the testosterone-alone or the placebo-plus-exercise group (P<0.05).
Muscle Strength
Muscle strength in the bench-press and the squatting exercises did not change significantly over the 10-week period in the group assigned to placebo with no exercise. The men in the testosterone-alone and placebo-plus-exercise groups had significant increases in the one-repetition maximal weights lifted in the squatting exercises, averaging 19 percent and 21 percent, respectively (Table 4 and Figure 1). Similarly, mean bench-press strength increased in these two groups by 10 percent and 11 percent, respectively. In the testosterone-plus-exercise group, the increase in muscle strength in the squatting exercise (38 percent) was greater than that in any other group, as was the increase in bench-press strength (22 percent).
Mood and Behavior
No differences were found between the exercise groups and the no-exercise groups or between the placebo groups and the testosterone groups in any of the five subcategories of anger assessed by the Multidimensional Anger Inventory. No significant changes in mood or behavior were reported by the men on the Mood Inventory or by their live-in partners, spouses, or parents on the Observer Mood Inventory.
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