depends what you like...
I've been clubbing on and off since 1991, so I have seen alot of changes...
went to twilo from 96 till it closed..fridays. Loved that place...best international dj's by far in NYC....
clubs i have frequented...limelight, vinyl, sound factory, centro-fly, copa (yes, latin club), palladium, robots, so many more...
right now..however, I only go when there is a dj I like around...not too pleased with the scene here right now.. went to Limelight last fall for jeff mills and richie hawtin (2 of my favs) but the people were so horrible...I literally had to kick the shit out of 4 or 5 guys cause they wouldnt stop harassing and touching me...
I like the summer season cause they have the sunday night boat cruises with great dj's..now those are sick!
fav party is the tronic party on monday nights...was at guernica..now to be at baktun....best techno party in the city hands down, baktun is on 14th street and 9th ave..very cool place as well...
I am trying out a new place for a little drum & bass this thursday....MINT...have heard good things...