I've run Aflutop a few times in the past, in between cycles.... at first I thought it helped, but in retrospect, I don't think it really did much for me....I've had chronic shoulder and knee pain.... a good long-term regimen for me has been concentrated glucosamine/chondroitin, gelatin (mixed in shakes), and plenty of EFA's... it'll take a few months before you start to see anything noticeable, but it will happen