Accutane

[c24k]

Maybe this isn't the right forum but i've seen this drug come up on here. What you may or may not know accutane is a very potent drug with severe side effects. There have been people kill themselves on this because of the severe depression it causes. If you have or have had depression or have a family history of it DO NOT take it! Accutane is also known to cause permanent irreversible depression in people with a history of depression. I know this for a fact because my mom is a nurse dealing with medications of all sorts every day. Accutane is mainly prescribed as a last resort treatment for severe cases of Acne Vulgaris and Acne Rosacea. My dermotologist kept trying to prescribe this to me but my mom knew about it and did more research on it. I also have a friend in the Navy i found out from him that Accutane is a banned substance in all branches of the US Armed Forces. Just my 2 cents of advice on this. I saw it on here and another BBing forum just not. Accutane is not something to mess around with just do A LOT of research on the drug and your family history if you really decide to use this.

 

[c24k]

I figure i'd better write a better description of Accutane if people really want to hear me out.

Isotretinoin
(13-cis-retinoic acid, vitamin A metabolite)

Drug Classes
Vitamin Metabolite
Acne Product
Retinoid (first generation)

Therapeutic Actions
Decreases sebaceous gland size and inhibits sebaceous gland differentiation, resulting in a reduction in sebum secretion; inhibits follicular keratinization; exact mechanism of action is not known.

Indications
1. Treatment of severe recalcitrant nodular acne unresponsive to conventional treatment
2. Unlabeled uses: Treatment of cutaneous disorders of keratinization; cutaneous T-cell lymphoma and leukoplakia, psoriasis.

Contradictions and Cautions
Contradicted with allergy to isotretinoin, parabens, or product components; pregnacy (has caused severe fetal malformations and spontaneous abortions); lactation.
Use cautiously with history of severe depression, suicidal ideation, diabetes mellitus, pediatric patients with genetic predisposition to age-related osteoporosis, a history of childhood osteoporosis, osteomalacia, other dieseases of bone metabolism

Available Forms
Capsules - 10,20,40 mg

Adverse Effects

• CNS: Lethargy, insomnia, fatigue, headache, pseudotumor cerebri (papilledema, headache, nausea, vomiting, visual disturbances); depression, psychoses, suicide, aggressive or violent behavior
• CV: Palpitations, tachycardia, vascular thrombotic disease
• Dermatologic: Skin fragility, dry skin, pruritus, rash, thinning of hair, peeling of palms and soles, skin infections, photosensitivity, nail brittleness, petechiae
• EENT: Cheilitis, eye irritation, conjunctivitis, corneal opacities, epistaxis
• GI: Nausea, vomiting, abdominal pain, anorexia, inflammitory bowel disease, dry mouth, gum irritation
• GU: White cells in the urine, proteinuria, hematuria
• HEMATOLOGIC: Elevated sedimentation rate, hypertriglyceridemia, abnormal liver function tests, increased fasting serum glucose
• MUSCULOSKELETAL: Skeletal hyperostosis, arthralgia, bone and joint pain and stiffness

• Respitory: Epistaxis, dry nose, bronchospasms.

Interactions
Drug-drug. Increased toxicity when taken with Vitamin A; avoid this combination.
2. Risk of increased adverse effects if combined with systemic corticosteroids, phenytoin; use caution if these combinations are used.

If taking
Consume as much water as you can. It is impossible to not have an adverse side effect (more than just one) will happen. Again use EXTREME CAUTION when taking this drug.

 

[cuts82]

Man depression of accutane has not been proven, usually users are heavily depressed in the first place because there skin is so bad before they start, so dont say "accutane causes severe depression" because its not founded . ive used it, no depression and i suffered depression all threw my teens and both my parents are manic depressants

 

[c24k]

Man depression of accutane has not been proven, usually users are heavily depressed in the first place because there skin is so bad before they start, so dont say "accutane causes severe depression" because its not founded . ive used it, no depression and i suffered depression all threw my teens and both my parents are manic depressants

I beg to differ on that. There have been deaths around here linked to accutane as it was found in their body. They committed suicide. Everyone has different reactions to drugs.

 

[cuts82]

I beg to differ on that. There have been deaths around here linked to accutane as it was found in their body. They committed suicide. Everyone has different reactions to drugs.

What out of like the millions upon millions of users wordwide there has only been a handful of suicide's that they have 'linked' to accutane, it proves nothing , its fucked that people kill them selfs and i feel for them but it happens and to blame a drug that has made so many peoples life that much better is silly

 

[c24k]

What out of like the millions upon millions of users wordwide there has only been a handful of suicide's that they have 'linked' to accutane, it proves nothing , its fucked that people kill them selfs and i feel for them but it happens and to blame a drug that has made so many peoples life that much better is silly

not trying to be silly. and its more than just a handful. Not everyone gets depression from it. maybe i would maybe i wouldn't i don't know. Just trying to put information about it on here. Not trying to be a jerk or a medical doctor.... is nice to have information right here without googling everything under the sun

 

[cuts82]

not trying to be silly. and its more than just a handful. Not everyone gets depression from it. maybe i would maybe i wouldn't i don't know. Just trying to put information about it on here. Not trying to be a jerk or a medical doctor.... is nice to have information right here without googling everything under the sun

I agree bro knowledge is power, but i think that it needs to be said that depression is rated as a 1-2% chance of getting while on it,
i would be more worried about informing people about the common sides such as liver toxicity, dry skin, sore joints, cholesterol issues . i think they are what are the main concerns

 

[daville]

read the story about the kid who wrecked a plane and killed himself. They found accutane in his system during the autopsy. His dad was a well known Gov. at the time also. Ever since that incident Accutane got ripped to pieces. I have take accutane twice and no problems at all. This kids parents made it very hard to get and they blamed a pill for the death of their kid but the cause of death was not proved to be the accutane. I have a very good derm and they have been perscribing it since the early 90's and have had no trouble in the 19 yrs. Its really not as bad as people think. People make juice out to be bad and they do the same about accutane. When both are used properly things go smooth!

 

[Nomak666]

read the story about the kid who wrecked a plane and killed himself. They found accutane in his system during the autopsy. His dad was a well known Gov. at the time also. Ever since that incident Accutane got ripped to pieces. I have take accutane twice and no problems at all. This kids parents made it very hard to get and they blamed a pill for the death of their kid but the cause of death was not proved to be the accutane. I have a very good derm and they have been perscribing it since the early 90's and have had no trouble in the 19 yrs. Its really not as bad as people think. People make juice out to be bad and they do the same about accutane. When both are used properly things go smooth!

I agree. Just cuz the drug was found in his system doesnt mean, it caused his suicide. Just like theyre blaming steroids for all the wwe wrestler's death. It's people who abuse drugs that give them a bad name. Im on accutane and although i felt depression for the first 2 weeks, you get over it. the depression is caused cuz you have all that acne. if my face was covered in zits, id be depressed even if i wasnt on accutane.

 

[iceman7230]

Very hard on the liver.

I took accutane for 4 months 50mgs ed and all I really had was bad chapped lips. Can somebody just bring me some chapstik, my lips hurt really bad GOSH!

 

[iron_matt-CB]

ive done like 3 4 month cycles of accutane and have never felt depressed from it. it was at 80mgs a day too which is very high. chapped lips were a bitch. kellogs was interviewing me to replace tony the tiger for the frosted flakes box!

 

[jonny jacked]

Man depression of accutane has not been proven, usually users are heavily depressed in the first place because there skin is so bad before they start, so dont say "accutane causes severe depression" because its not founded . ive used it, no depression and i suffered depression all threw my teens and both my parents are manic depressants

First off the link between Accutane and depression is well proven, and linked (don't ask me to post studies, its not like I have them laying around - and I’m not about to go trek all over the net to try and convince you).
To make the statement that "users are heavily depressed in the first place." how could you possibly profess to know the mental state of all accutance users? easy - you can't.
You on the other hand may very well have been depressed before hand (as it looks like you just stated), This BY NO MEANS suggests that ALL accutane users have a prior history of depression - just because you did. You even state both your parents suffer from depression, proving my next point, that depression is linked to heredity.

does accutane make all users depressed? no, of course not - it did not for me. Though - some will suffer from depression.
The fact that you stated that you were depressed prior to use, shows your severe lack of proper understanding of the cautions with the med. People with prior depression should not use accutane - as symptoms may become worse and suicidal thoughts may present.

be careful presenting medically relevant information - some may just take it as gospel truth.

 

[Toptoon1]

First off the link between Accutane and depression is well proven, and linked (don't ask me to post studies, its not like I have them laying around - and I’m not about to go trek all over the net to try and convince you).
To make the statement that "users are heavily depressed in the first place." how could you possibly profess to know the mental state of all accutance users? easy - you can't.
You on the other hand may very well have been depressed before hand (as it looks like you just stated), This BY NO MEANS suggests that ALL accutane users have a prior history of depression - just because you did. You even state both your parents suffer from depression, proving my next point, that depression is linked to heredity.

does accutane make all users depressed? no, of course not - it did not for me. Though - some will suffer from depression.
The fact that you stated that you were depressed prior to use, shows your severe lack of proper understanding of the cautions with the med. People with prior depression should not use accutane - as symptoms may become worse and suicidal thoughts may present.

be careful presenting medically relevant information - some may just take it as gospel truth.

"First off the link between Accutane and depression is well proven, and linked"

Furthest thing from the truth! The exact opposite is true. The link between acutane and depression is NOT proven or well linked!

be careful presenting medically relevant information - some may just take it as gospel truth.

Exactly what I was thinking, shame it wasnt followed.

 

[cuts82]

First off the link between Accutane and depression is well proven, and linked (don't ask me to post studies, its not like I have them laying around - and I’m not about to go trek all over the net to try and convince you).
To make the statement that "users are heavily depressed in the first place." how could you possibly profess to know the mental state of all accutance users? easy - you can't.
You on the other hand may very well have been depressed before hand (as it looks like you just stated), This BY NO MEANS suggests that ALL accutane users have a prior history of depression - just because you did. You even state both your parents suffer from depression, proving my next point, that depression is linked to heredity.

does accutane make all users depressed? no, of course not - it did not for me. Though - some will suffer from depression.
The fact that you stated that you were depressed prior to use, shows your severe lack of proper understanding of the cautions with the med. People with prior depression should not use accutane - as symptoms may become worse and suicidal thoughts may present.

be careful presenting medically relevant information - some may just take it as gospel truth.

Show us the proof!

i researched accutane for over a year and never found any study that conclusively proved it?

I was not depressed or had not had depression for years when i went on tane , my point was if im so genetically predisposed then why the fuck didnt i get it? and i never said every who goes on accutane is depressed, i said the ones that say they get depression from tane are probably depressed from havin real bad acne in the first place and i think that is very logical

Ss show us you studys to back up the supposed proven facts

 

[gladiator21]

im on acuutane from the past cycle i did and it fucked my back up.....it was the DECA....i got huge welt sized pimps on my lower back that would pop and bleed through my shirt when i would lay on the bench...i got prescribed accutane by my dermo about 2 1/2 weeks ago. Im just past the 2nd week on it and my shoulders cleared up a alot so far. I do have increased aggresion though. the chap lips and dry skin sucks...but it seems to be working

 

[c24k]

im on acuutane from the past cycle i did and it fucked my back up.....it was the DECA....i got huge welt sized pimps on my lower back that would pop and bleed through my shirt when i would lay on the bench...i got prescribed accutane by my dermo about 2 1/2 weeks ago. Im just past the 2nd week on it and my shoulders cleared up a alot so far. I do have increased aggresion though. the chap lips and dry skin sucks...but it seems to be working

yea accutane will clear up acne very fast. it dries up your skin to close off the pores. I don't know the accuracy of it but it is SAID to keep acne away for 10 years. I don't know if that is for everyone or for ppl that have severe acne. Best thing to do is double (if you can) or just increase your water intake. No sodas or any liquid that would normally dehydrate you. Think of it as being on a cycle and just drink alot of water. Its also been recommended to avoid too much sunlight.

 

[Satva1100]

how do you know how many mg to take per day?

 

[Toptoon1]

how do you know how many mg to take per day?

Please dont tell me your planning on putting yourself on a acutane course.

 

[Satva1100]

Please dont tell me your planning on putting yourself on a acutane course.

i wasnt. but why?

 

[Nomak666]

how do you know how many mg to take per day?

People usually start 40mg ed split into 2 doses (am and pm). then after 2 months bump it up to 60mg, and then in another month or 2, bump it up to 80mg. i would not go over 80 unless your under supervision of a doctor cuz your liver values will be shot.

 

[Satva1100]

i used to be prescribed it when i was a teen but i forget the dose so i was just wondering. i think i was on for 6 months. i dont get acne on my face but my back is a mess ,even before i ever used steroids. i was thinking about going back to a doctor cuz my insurance would pay for it cuz thats expensive to buy on your own

 

[needtogetaas]

I is pretty harsh though.

 

[Toptoon1]

i wasnt. but why?

Cause how harsh it is on the liver, and how you should have bloodtests every month while on it.

 

[pov]

im hoping to start accutane, i got a appointment with a dermotolagist in about 6 weeks, should hope to get it and try for the first time. ive had really bad acne since i was 18 now im 22.
side effects or not im ready for it cus my lifes wasting away and i cnt really show my upper body.
my mom suffers from despression but i am more like a ticking timebomb ready for a scrap etc.

my point is when acne is that bad i think most people will just take accutane not caring about the sides.

ill post how i get on once i get it. im on cycle to so i guess ill use my self as a crash dummy to see the sides.

ps the gear hasnt really made my acne any worser than it is already.

 

[c24k]

im hoping to start accutane, i got a appointment with a dermotolagist in about 6 weeks, should hope to get it and try for the first time. ive had really bad acne since i was 18 now im 22.
side effects or not im ready for it cus my lifes wasting away and i cnt really show my upper body.
my mom suffers from despression but i am more like a ticking timebomb ready for a scrap etc.

my point is when acne is that bad i think most people will just take accutane not caring about the sides.

ill post how i get on once i get it. im on cycle to so i guess ill use my self as a crash dummy to see the sides.

ps the gear hasnt really made my acne any worser than it is already.

not a smart idea to run accutane while on cycle you really should wait. and if you do u better have a damn good liver support to take with it and drink tonnes of water i mean tonnes

 

[WinnyPumps]

how do you know how many mg to take per day?

Derms prescribe the mg's depending on your bodyweight. Accutane works awesome and if you take your liver supps, don't drink alchohol the stuff works great with minimal side effects.
I'm on a cycle right now of Test Cyp/Var and I'm taking 40mg ed Accutane. Everythnig is fine. Some of you guys are making a big deal out of it reagrding the depression.

 

[jonny jacked]

I cannot believe I’m actually doing this, the fact that I let you suck me into posting this - I could care less what a couple of kids on here believe, but since you asked, I feel obliged.
Even Roche Labs, the makers of accuatane have cited the link between depression and the drug. Now I’m no rocket scientist, but when the makers of ‘tane are saying it can cause depression (note I said CAN – not WILL in 100% of cases) I think we should at least admit there must be SOMETHING to it.
The reality is, you can find a study to say whatever you want. There are countless studies on line saying it does not, just like there are countless that says it does. But I draw your attention once again to the fact that the drug makers are citing a link – but whatever.

Oh, and I cut and pasted the below (no, not my words) sorry for the format.
- In 1998, Roche Laboratories addressed a letter to physicians stating that:
"Accutane may cause depression, psychosis and, rarely, suicidal ideation, suicide attempts and suicide. Discontinuation of Accutane therapy may be insufficient; further evaluation may be necessary. No mechanism of action has been established for these events."

- Accutane ranks fifth in reports connected to depression, compared with all drugs listed in the FDA's Adverse Event Reporting System (AERS) database through June 2000.
Many case studies have found a potential connection between Accutane use and psychiatric disorders, and some studies have found Accutane causes depressive behavior in mice. Depression occurred in some people with no prior history of the disorder.
Some Accutane users found that their symptoms of depression resolved once they stopped using the drug, and came back when it was reinstated. It should be noted, however, that depression and suicidal behavior persisted in some cases, even after the patient quit using isotretinoin.
Researchers at the University of Bath, UK believe Accutane may disrupt the way serotonin is made and utilized by the body. Low levels of serotonin have been linked to depression, bipolar disorder, anxiety disorders, and aggression. Their research identifies a possible mechanism for the link between depression and isotretinoin.

Here is a link to another article citing a study regarding the link between accutane and depression:
Study Links Accutane to Depression

 

[joe d]

how do you know how many mg to take per day?

Recommended dosage for Accutane


The recommended dosage range for Accutane is 0.5 to 1 milligram per 2.2 pounds of body weight, divided into 2 doses daily, for 15 to 20 weeks. For very severe cases, the doctor may increase the daily dose to as much as 2 milligrams per 2.2 pounds.
If after a period of 2 months or more off therapy, severe cystic acne persists, your doctor may prescribe a second course of therapy.

How should you take Accutane?


Take Accutane two times a day with a meal, unless your doctor tells you otherwise. Swallow the capsule. Don't suck or chew it. Take it with a full glass of water, milk, or other nonalcoholic liquid. Follow your doctor's instructions carefully.
Depending on your reaction to Accutane, your doctor may need to adjust the dosage upward or downward. If you respond quickly and very well, your doctor may take you off Accutane even before the 15 or 20 weeks are up.
After you finish taking Accutane, there should be at least a 2-month "rest period" during which you are off the drug. This is because your acne may continue to get better even though you are no longer taking the medication. Once the 2 months are up, if your acne is still severe, your doctor may want to give you a second course of Accutane. If you are still growing, your doctor may recommend a longer "rest period."
Avoid consumption of alcoholic beverages.
Read the patient information leaflet available with the product.
Do not crush the capsules.
Do not share Accutane with anyone because of the risk of birth defects and other serious side effects.

• If you miss a dose...
  Take the forgotten dose as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at the same time.

• Storage instructions...
  Store at room temperature, away from light.

 

[jonny jacked]

Show us the proof!

i researched accutane for over a year and never found any study that conclusively proved it?

I was not depressed or had not had depression for years when i went on tane , my point was if im so genetically predisposed then why the fuck didnt i get it? and i never said every who goes on accutane is depressed, i said the ones that say they get depression from tane are probably depressed from havin real bad acne in the first place and i think that is very logical

Ss show us you studys to back up the supposed proven facts

you remind me of that movie "Jerry Maguire" SO ME THE PROFF!! or money.. whatever, it made me laugh.

again you too (Tarpoon - or whatever you name is).

you both sound like young guys so a little advice - try not to get too worked up on here - read and learn. thats what they say.

you state again, that "the ones that say they get depressed from accutane are probably depressed from having real bad acne in the first place - and I think that is very logical"

I draw your attention to my previous post (I put it in bold and even underlined it for you)

that entire sentance lacks ANY real logic whatsoever. first off, people that get depressed from tane, are already depressed? all of them? or just some? what are you basing this on? fact? or your personal opinion? if its the latter, I think you need to clarify that.

I'm sure this is just your "logical " opinion, but you need to realize (and I will use myself as an example) one: not everyone who uses tane, has bad acne to begin with. mine was juice related, and only on my shoulders and back - and was not bad.
second, not everyone with bad acne suffers depression from it, but yet, suffer suicidal thoughts after using tane (as stated by Roche, the makers of tane)

I was going to continue, but what am I doing here?? - believe what you want.

 

[Toptoon1]

In response to your last two posts Jonny Jacked.

"I cannot believe I’m actually doing this, the fact that I let you suck me into posting this - I could care less what a couple of kids on here believe, but since you asked, I feel obliged."

If that’s your attitude then why did you bother? I personally would have preferred you didn’t considering your disrespect. No one "sucked you in" to anything! What did happen was someone disagreed with you. If you cant back up your claim without a logical explanation then simply state that it is your opinion and be done with it. There is no need to act as if your precious time is being wasted cause I know better. I think if you cant be respectful in your replay then don’t bother. But hey what do I know? Im just a kid, and you can care less.

So, you felt obliged? Obliged to what? Obliged to do a quick google search of (does accutane cause depression)? Well you found it! You didnt go with the first hit cause that site just shows how toxicology reports confirm there was no traces of accutane in that boy who intentionally crashed the plane and that wouldn’t have worked for your argument.

You also chose not to go with a solid report by FOX news who reported on a study that is now published in the journal of dermatology. The study also interviews dermatologists. MD’s who have treated countless patients and have stated they have seen no mood alterations in there patients who are prescribed accutane.

Elaine Siegfried MD.

"Most dermatologists are in agreement that Accutane is a miracle drug for acne. I have treated many thousands of patients with it, and I have never seen clinically significant mood alterations in any of my treated patients."

The same Report also has a statement from Psychiatrist Douglas G. Jacobs, who is a consultant to Roche labs. Jacobs states,

"I have spent more time reviewing the studies than anyone and there is just no evidence that Accutane causes depression or increases the risk of suicide,"

What you did do is butcher a report by Angela Palmer who writes for About.com. She has no medical degree. What she does have is an esthetics certificate from a beauty institute, Another certificate in acne treatment, skin exfoliation and resurfacing, and a certificate in advanced skin care and chemical exfoliation. This lady is an author and a beautician.

You specifically left out sentences in her paragraphs that would denote the point your trying to make.

Heres some of the missing words from your study.

"While countless case reports suggest a relationship between Accutane use and depression, proving this connection has been difficult. Some studies suggest acne itself is more likely to cause depression in sufferers than Accutane use. Others have found no definitive link between Accutane use and an increased risk of depression."

"Many acne sufferers find they are depressed because of their acne, and isotretinoin helps to clear their skin, making them feel less depressed and more confident."

(that one sounds familiar)

"Many case studies have found a potential connection between Accutane use and psychiatric disorders, and some studies have found Accutane causes depressive behavior in mice. Depression occurred in some people with no prior history of the disorder. Other patients had factors, such as substance abuse, a family history, or stressful events in their lives, which may have contributed to their depression"

"According to the FDA, between 1982 and 2000, there were 394 reported cases of depression and 37 suicides of people who were taking, or had taken, isotretinoin. Thirteen of these suicides occurred within three months after the patient had stopped using Accutane."

Consider the above paragraph i quoted from your report. Now consider that Roche labs reports that over 12,000,000 people have used this drug. 37 suicides. 394 cases of depression. 12,000,000 users. Do you really think depression is an issue with accutane?

A better attitude and mutual respect would be appriciated from your replys, but not expected. What is expected is that you not give false or misleading information from poor sources that you have butchered to make your point.

Your source: http://acne.about.com/od/acnetreatments/a/sideeffectsaccu.htm

 

[Toptoon1]

you remind me of that movie "Jerry Maguire" SO ME THE PROFF!! or money.. whatever, it made me laugh.

again you too (1) (Tarpoon - or whatever you name is).

(2) you both sound like young guys so a little advice - try not to get too worked up on here - read and learn. thats what they say.

you state again, that (quoted by cuts) "the ones that say they get depressed from accutane are probably depressed from having real bad acne in the first place - and I think that is very logical"

I draw your attention to my previous post (I put it in bold and even underlined it for you)

(3) that entire sentance lacks ANY real logic whatsoever. first off, people that get depressed from tane, are already depressed? all of them? or just some? what are you basing this on? fact? or your personal opinion? if its the latter, I think you need to clarify that.

I'm sure this is just your "logical " opinion, but you need to realize (and I will use myself as an example) one: not everyone who uses tane, has bad acne to begin with. mine was juice related, and only on my shoulders and back - and was not bad.
second, not everyone with bad acne suffers depression from it, but yet, suffer suicidal thoughts after using tane (as stated by Roche, the makers of tane)

(4) I was going to continue, but what am I doing here?? - believe what you want.

(1) Its TopToon, I dont know how you could have missed that. Unless that was your attempt at humor.​

(2) I do read and learn, but you cant believe everything you read. Case in point.​

(3) So that entire sentence lacks any logic whatsoever? Thats funny. "What are you basing this on? Fact? your personal opinion?" I dont know. I didnt write it. CUT did. Maybe he based it on the same article you keep refferencing?heres an excerpt from it. (im gonna put it in bold, and even underline it for you)​

"While countless case reports suggest a relationship between Accutane use and depression, proving this connection has been difficult. Some studies suggest acne itself is more likely to cause depression in sufferers than Accutane use. Others have found no definitive link between Accutane use and an increased risk of depression.​

Many acne sufferers find they are depressed because of their acne, and isotretinoin helps to clear their skin, making them feel less depressed and more confident."

(4) Trying to put people down? Butchering other peoples work trying to make a point?

Its always a good idea to post where you got your information. I will do it for you. Accutane Side Effects - Depression and Accutane Side Effects​

 

[cuts82]

Man toptoon beat me to it, jj you have nothing, let it go