It depends. Some people i know ran accutane for 6-8 months, cleared their acne for good and also nothing pops up when they start a cycle. ive also heard of people who take accutane for 6-8 months and it came back. also depends on what compounds youre running. you can always run a low does of 10-20mg of accutane ed or eod on cycle with some liver support and avoid oral compounds.