You hit in on the head tere bro...............Only will know after youi try it....I've tried them all....2,3,4,5 days splits...........3 on 1 off seems to work the best for ME, but who knows............geared up, I can go 5x week without fail............now, back to your ?, It's best to hit the major muscles (legs, back) earlier in the week after your layoff...then save the smaller muscles (delts and arms) towards the end..........toss in chest somewhere in the middle.......I like to do both legs and back after off days......IE. Back, chest, off, legs, delts, arms...........or Back/trps, chest/calvels/ bis, off, legs, delts/tris, off..........