I started all my supps weeks before starting my cycle, but after I had my baseline blood test done. I do think it is the var. I have read many studies on lipids and aas and test lowers TC but maintains the inital ratio (no significant change), primo I could not find a lot on specifically but what little I have found appears to be the same as test, var and winny appear to be the worst for drastically reducing HDL (at a minimum). I once did a cycle of prop, tren, eq & winny mu TC shot up to 274 did not get the ratio but I am sure it was not good. I was not on any supps to help control cholesterol though so on the bright side I do think that the 64 pills I take daily are helping some