I haven't heard anyone speak of gyno when taking 1-Test, nor with 1,4-ADD. As far as I know with the 1-Test, there's no increase in estrogen, so no estrogenic sides associated.
As far as HPTA suppression and sex drive is concerned, I wouldn't doubt it screws some people up pretty bad. As for me, I still have a sex drive. It's not overpowering in any way, but it's still present. And I haven't noticed any shrinkage in my testes, so I assume my endogenous test production isn't down too low as of yet. Though I'm not going to take any chances. I'm going to use clomid post cycle for sure.
The source of the 1-Test that Molecular uses I heard was far superior to the competition. Whether or not there's any truth to that, I don't know. Though I'm sure that the purity has a huge part in the gains you can expect, as well as whether or not you'll experience any negative sides. I'm sure that with the unpure shit out there, they probably have a lot of fillers in there that can really screw things up. It's just speculation though.