GHRP6 for bulking

[John Juan]

GHRP6 administered subcutaneously dramatically increases appetite for up to 7 hours via secretion of ghrelin and HGH release. If you are interested in bulking up and putting on serious mass and strength, research GHRP6 prior to meals several times a day. The appetite increase is indescribable!!!



Glucocorticoid-dependent stimulation of adiposity and appetite by a ghrelin mimetic in the rat.

AuthorsTung YL, et al. Show all Journal
Eur J Endocrinol. 2004 Jun;150(6):905-11.

Affiliation
Abstract
OBJECTIVE: Chronic administration of GH secretagogues (GHSs) induces a state of positive energy balance in rodents by a GH-independent mechanism. Here we sought to determine to what extent the GHS effects to increase food intake and increase fat accumulation are glucocorticoid-dependent.

DESIGN: The effects of twice-daily s.c. injections of GH-releasing peptide-6 (GHRP-6) (250 microg/kg) for 2 weeks on body weight, food intake and fat pad weight were determined in both adrenalectomised (ADX) rats (with or without basal corticosterone replacement) and adrenal-intact rats.

RESULTS: All GHS-injected rats had a significantly increased body weight at the end of 2 weeks of treatment compared with saline controls. However, increased fat accumulation was only seen in adrenal-intact rats, with a 15% increase in s.c. inguinal (P<0.05 vs saline controls) and 20% increase in visceral mesenteric (P<0.05) fat pad weights following GHS treatment. The increased body weight observed in ADX rats following GHS treatment was not due to increased fat mass or increased weight of other organs measured. Food intake was increased for up to 7 h following a single injection of GHRP-6 in both the adrenal-intact (P<0.01) and corticosterone-replacement groups (P<0.05). This stimulating effect on food intake was not observed at any time point in the ADX rats without corticosterone replacement.

CONCLUSION: These data suggest that GHS-induced body weight gain is glucocorticoid-independent. However, basal levels of glucocorticoids are permissive for the GHS-induced increase in food intake whilst activation of the hypothalamo-pituitary-adrenal axis appears to contribute to the GHS-induced accumulation of fat mass.

 

[John Juan]

The top bodybuilders in the USA that I know use GHRP6 off season to stimulate their appetite in order to consume the ungodly amount of food they need to takedown to get up to 300+Lbs.

 

[Elvia1023]

GHRP-6 is definitely the GHRP for bulking... especially if you don't have a big appetite.

 

[John Juan]

GHRP-6 is definitely the GHRP for bulking... especially if you don't have a big appetite.

The first time I researched ghrp6 it caught me off guard as it does most people. I couldn't stop eating. At first you get a strong flushed feeling which after a few minutes turns into an insatiable hunger.

 

[John Juan]

Back a couple years ago a popular hgh sponsor sold fake hgh that was really ghrp6. I took it and got a crazy flush and didn't know what was going on. I began sweating profusely. Then, 10 minutes later I started eating like crazy. I went through all the cupboards until no food was left. It was later found that that company really put ghrp6 in the vials. I know it had to be a seriously high dose.

 

[Elvia1023]

Back a couple years ago a popular hgh sponsor sold fake hgh that was really ghrp6. I took it and got a crazy flush and didn't know what was going on. I began sweating profusely. Then, 10 minutes later I started eating like crazy. I went through all the cupboards until no food was left. It was later found that that company really put ghrp6 in the vials. I know it had to be a seriously high dose.

Yeah I once took about 500mcg GHRP-6 on an empty stomach... never again... unless I enter a food eating competition

 

[John Juan]

Yeah I once took about 500mcg GHRP-6 on an empty stomach... never again... unless I enter a food eating competition

Good Lord!!!!! I've never dosed it that high.

 

[John Juan]

The positive effects of growth hormone-releasing peptide-6 on weight gain and fat mass accrual depend on the insulin/glucose status.

AuthorsGranado M, et al. Show all Journal
Endocrinology. 2010 May;151(5):2008-18. doi: 10.1210/en.2009-1394. Epub 2010 Mar 10.

Affiliation
Abstract
Ghrelin and GH secretagogues, including GH-releasing peptide (GHRP)-6, stimulate food intake and adiposity. Because insulin modulates the hypothalamic response to GH secretagogues and acts synergistically with ghrelin on lipogenesis in vitro, we analyzed whether insulin plays a role in the metabolic effects of GHRP-6 in vivo. Streptozotocin-induced diabetic rats received saline, GHRP-6, insulin, or insulin plus GHRP-6 once daily for 8 wk. Rats receiving saline suffered hyperglycemia, hyperphagia, polydipsia, and weight loss. Insulin, but not GHRP-6, improved these parameters (P < 0.001 for all), as well as the diabetes-induced increase in hypothalamic mRNA levels of neuropeptide Y and agouti-related peptide and decrease in proopiomelanocortin. Cocaine amphetamine-related transcript mRNA levels were also reduced in diabetic rats, with GHRP-6 inducing a further decrease (P < 0.03) and insulin an increase. Diabetic rats receiving insulin plus GHRP-6 gained more weight and had increased epididymal fat mass and serum leptin levels compared with all other groups (P < 0.001). In epididymal adipose tissue, diabetic rats injected with saline had smaller adipocytes (P < 0.001), decreased fatty acid synthase (FAS; P < 0.001), and glucose transporter-4 (P < 0.001) and increased hormone sensitive lipase (P < 0.001) and proliferator-activated receptor-gamma mRNA levels (P < 0.01). Insulin normalized these parameters to control values. GHRP-6 treatment increased FAS and glucose transporter-4 gene expression and potentiated insulin's effect on epididymal fat mass, adipocyte size (P < 0.001), FAS (P < 0.001), and glucose transporter-4 (P < 0.05). In conclusion, GHRP-6 and insulin exert an additive effect on weight gain and visceral fat mass accrual in diabetic rats, indicating that some of GHRP-6's metabolic effects depend on the insulin/glucose status.

 

[workhard2121]

Absolutely an essential for me when bulking! Makes my appetite skyrocket even more.

Sent from my SM-G900P using Tapatalk

 

[C0LUMB0]

so whats the dosing protocol...as in mcg per day ?

is the pin schedule twice a day ED ?

 

[John Juan]

so whats the dosing protocol...as in mcg per day ?

is the pin schedule twice a day ED ?

If you are using ghrp6 to increase appetite then take 100mcg prior to meals. If that doesn't make you extremely hungry then up the dose by 50mcg until you find the best dose for you.

If you are mostly interested in hgh release then take 100mcg ghrp6 with 100mcg cjc1295 no dac 3x/day evenly spaced out throughout the day. SubQ administration is most common.

 

[John Juan]

Growth-hormone-releasing peptide 6 (GHRP6) prevents oxidant cytotoxicity and reduces myocardial necrosis in a model of acute myocardial infarction.

AuthorsBerlanga J, et al. Show all Journal
Clin Sci (Lond). 2007 Feb;112(4):241-50.

Affiliation
Abstract
Therapies aimed at enhancing cardiomyocyte survival following myocardial injury are urgently required. As GHRP6 [GH (growth hormone)-releasing peptide 6] has been shown to stimulate GH secretion and has beneficial cardiovascular effects, the aim of the present study was to determine whether GHRP6 administration reduces myocardial infarct size following acute coronary occlusion in vivo. Female Cuban Creole pigs were anaesthetized, monitored and instrumented to ensure a complete sudden left circumflex artery occlusion for 1 h, followed by a 72 h reperfusion/survival period. Animals were screened clinically before surgery and assigned randomly to receive either GHRP6 (400 microg/kg of body weight) or normal saline. Hearts were processed, and the area at risk and the infarct size were determined. CK-MB (creatine kinase MB) and CRP (C-reactive protein) levels and pathological Q-wave-affected leads were analysed and compared. Evaluation of the myocardial effect of GHRP6 also included quantitative histopathology, local IGF-I (insulin-growth factor-I) expression and oxidative stress markers. GHRP6 treatment did not have any influence on mortality during surgery associated with rhythm and conductance disturbances during ischaemia. Infarct mass and thickness were reduced by 78% and 50% respectively, by GHRP6 compared with saline (P<0.01). More than 50% of the GHRP6-treated pigs did not exhibit pathogological Q waves in any of the ECG leads. Quantitative histopathology and CK-MB and CRP serum levels confirmed the reduction in GHRP6-mediated necrosis (all P<0.05). Levels of oxidative stress markers suggested that GHRP6 prevented myocardial injury via a decrease in reactive oxygen species and by the preservation of antioxidant defence systems (all P<0.05). Myocardial IGF-I transcription was not amplified by GHRP6 treatment compared with the increase induced by the ischaemic episode in relation to expression in intact hearts (P<0.01). In conclusion, GHRP6 exhibits antioxidant effects which may partially contribute to reduce myocardial ischaemic damage.

 

[C0LUMB0]

If you are using ghrp6 to increase appetite then take 100mcg prior to meals. If that doesn't make you extremely hungry then up the dose by 50mcg until you find the best dose for you.

If you are mostly interested in hgh release then take 100mcg ghrp6 with 100mcg cjc1295 no dac 3x/day evenly spaced out throughout the day. SubQ administration is most common.

thanks man, yes appetite stimulation is what i would be looking for out of it.

how soon before a meal do you pin ? and typically how many weeks can you run it for ?

 

[Pumped Up Ya]

Yea I'm tempted to grab my iPod shoot 500mcgs ghrp6 and walk into Chinese buffet

Sent from my SPH-D600 using Tapatalk 2

 

[John Juan]

thanks man, yes appetite stimulation is what i would be looking for out of it.

how soon before a meal do you pin ? and typically how many weeks can you run it for ?

It kicks in minutes after taking it. You can run ghrp6 year round. If it gets to the point that it doesn't make you hungry then take a week off and the receptors will be just like new once again.

 

[John Juan]

Pituitary growth hormone stores fully replenish every 3 hours meaning ghrp6 can be used every 3 hours around the clock and still get maximal
Hgh secretion.

 

[Elvia1023]

Yea I'm tempted to grab my iPod shoot 500mcgs ghrp6 and walk into Chinese buffet

Sent from my SPH-D600 using Tapatalk 2

Every time I watch man vs food and they have an eating challenge and fail I always think you should have injected 500mcg GHRP-6 before eating!

 

[John Juan]

Every time I watch man vs food and they have an eating challenge and fail I always think you should have injected 500mcg GHRP-6 before eating!

I dated a fat girl once who seemed like she took 500mcg ghrp6 before each meal. That girl ate as much as I did after I came off a 9 month precontest diet. She sure could cook though. I miss that a lot.

 

[C0LUMB0]

how does ghrp6 rate when compared to ghrp2 ... ?

 

[John Juan]

how does ghrp6 rate when compared to ghrp2 ... ?

Ghrp6 is better for appetite stimulation. Ghrp2 has a stronger HGH release.

 

[Elvia1023]

Ghrp6 is better for appetite stimulation. Ghrp2 has a stronger HGH release.

x2

They are very similar though in their effects.

Don't ever use GHRP-6 when cutting I am struggling with GHRP-2 as that can increase appetite too. After I inject it's a major struggle not to eat the entire fridge.

I think when cutting hexarelin and ipamorelin are best. GHRP-2 too if you don't get much of an appetite increase from it.

Overall GHRP-2 is probably the best all rounder.

GHRP-6 when you want lots of gh and trying to gain big weight.

 

[John Juan]

One of the first things users of ghrp6 notice is rapid strength gain.

 

[John Juan]

GHRP-6 was the first of a family of synthetic peptides discovered that will enhance the release of the Growth Hormone by the pituitary gland in a dose-dependent manner and as a chain reaction also cause a rise in IGF-1 levels in the body.

 

[Elvia1023]

One of the first things users of ghrp6 notice is rapid strength gain.

This has been mentioned by many recently. I usually dose my ghrp's pre workout . With 6 though I do it a little earlier then I have a big meal. 1 hour later I will have a light meal/snack for preworkout. Then I dose the ghrp-6 post workout and eat a massive meal full of protein and carbs.

 

[John Juan]

This has been mentioned by many recently. I usually dose my ghrp's pre workout . With 6 though I do it a little earlier then I have a big meal. 1 hour later I will have a light meal/snack for preworkout. Then I dose the ghrp-6 post workout and eat a massive meal full of protein and carbs.

One of the top amateur bodybuilders in the USA used ghrp6 to put on 60Lbs. His response to it was unreal. He weighs 285Lbs now very lean. I expect him to turn pro this year.

 

[John Juan]

Influence of sex, age and adrenergic pathways on the growth hormone response to GHRP-6.

AuthorsPeñalva A, et al. Show all Journal
Clin Endocrinol (Oxf). 1993 Jan;38(1):87-91.

Abstract

OBJECTIVE: His-dTrp-Ala-Trp-dPhe-Lys-NH2 (GHRP-6) is a synthetic compound that releases GH in a dose-related and specific manner in several species including man. To further characterize the effects of GHRP-6 on GH secretion in normal human subjects, we assessed plasma GH levels following GHRP-6 administration in normal male adult subjects, normal female adult subjects at different stages of their menstrual cycle and in normal prepubertal male and female children. We also studied the influence of adrenergic pathways on GHRP-6 induced GH secretion in normal adult male subjects.

DESIGN: In a group of eight volunteers the following tests were carried out: GHRP-6 alone (1 microgram/kg i.v. at 0 minutes); propranolol (40 mg p.o. at -30 minutes) plus GHRP-6; and prazosin (3 mg p.o. at -120 minutes) plus GHRP-6. Another group of eight volunteers were studied with GHRP-6 as above; clonidine alone (300 mg p.o. at -60 minutes); and clonidine plus GHRP-6. A group of nine women were studied with 1 microgram/kg i.v. of GHRP-6 at 0 minutes, at different stages of their menstrual cycle. Finally, 12 children were studied with GHRP-6 using the same dose and methods as above.

PATIENTS: Twenty-five normal adult subjects (16 male and nine female) and 12 normal prepubertal children (six male and six female) wer studied after giving informed consent.

MEASUREMENTS: Plasma GH levels were measured by radioimmunoassay.

RESULTS: No differences in GH responses to GHRP-6 were found between children and normal adult male or female subjects at different stages of their menstrual cycle. Administration of propranolol and clonidine did not modify the GH responses to GHRP-6 in male adults. In contrast, prazosin administration induced an increase in plasma GH levels that was statistically different from that of GHRP-6 alone (. < 0.05 between area under curve).

CONCLUSIONS: GHRP-6 exerts a potent stimulatory effect on GH secretion in adults and children. Its effects, at least at the dose studied, are independent of sex and age. Noradrenergic pathways through alpha 2 adrenergic receptors are unlikely to influence this response.

 

[John Juan]

I have my personal training client on 125mcg GHRP6 and 100mcg cjc1295 no dac, prior to each meal. He has gained 5Lbs in two weeks and his strength is exploding!

 

[John Juan]

Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues

Summary
Aging is associated with increased adiposity in white adipose tissues and impaired thermogenesis in brown adipose tissues; both contribute to increased incidences of obesity and type 2 diabetes. Ghrelin is the only known circulating orexigenic hormone that promotes adiposity. In this paper, we show that ablation of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R) improves insulin sensitivity during aging. Compared to wild-type (WT) mice, old Ghsr−/− mice have reduced fat and preserve a healthier lipid profile. Old Ghsr−/− mice also exhibit elevated energy expenditure and resting metabolic rate, yet have similar food intake and locomotor activity. While GHS-R expression in white and brown adipose tissues was below detection in the young mice, GHS-R expression was readily detectable in visceral white fat and interscapular brown fat of the old mice. Gene expression profiles reveal that Ghsr ablation reduced glucose/lipid uptake and lipogenesis in white adipose tissues, but increased thermogenic capacity in brown adipose tissues. Ghsr ablation prevents age-associated decline of thermogenic gene expression of uncoupling protein 1 (UCP1). Cell culture studies in brown adipocytes further demonstrate that ghrelin suppresses the expression of adipogenic and thermogenic genes, while GHS-R antagonist abolishes ghrelin’s effects and increases UCP1 expression. Hence, GHS-R plays an important role in thermogenic impairment during aging. Ghsr ablation improves aging-associated obesity and insulin resistance by reducing adiposity and increasing thermogenesis. GHS-R antagonists may be a new means of combating obesity by shifting the energy balance from obesogenesis to thermogenesis.

 

[John Juan]

Doing a clean bulk at around 5,000 calories can be so difficult after a few weeks. You can only do so many things to make extra lean ground turkey breast and brown rice taste good. That's where ghrp6 is worth it's weight in gold! Even dog food is edible after a shot of ghrp6.

 

[Elvia1023]

The effects of GH-releasing peptide-6 (GHRP-6) and GHRP-2 on intracellular adenosine 3',5'-monophosphate (cAMP) levels and GH secretion in ovine and rat somatotrophs.

Wu D1, Chen C, Zhang J, Bowers CY, Clarke IJ.

Abstract

The mechanism of action of GH-releasing peptide-6 (GHRP-6) and GHRP-2 on GH release was investigated in ovine and rat pituitary cells in vitro. In partially purified sheep somatotrophs, GHRP-2 and GH-releasing factor (GRF) increased intracellular cyclic amp (cAMP) concentrations and caused GH release in a dose-dependent manner; GHRP-6 did not increase cAMP levels. An additive effect of maximal doses of GRF and GHRP-2 was observed in both cAMP and GH levels whereas combined GHRP-6 and GHRP-2 at maximal doses produced an additive effect on GH release only. Pretreatment of the cells with MDL 12,330A, an adenylyl cyclase inhibitor, prevented cAMP accumulation and the subsequent release of GH that was caused by either GHRP-2 or GRF. The cAMP antagonist, Rp-cAMP also blocked GH release in response to GHRP-2 and GRF. The cAMP antagonist did not prevent the effect of GHRP-6 on GH secretion whereas MDL 12,330A partially reduced the effect. An antagonist for the GRF receptor, [Ac-Tyr1,D-Arg2]-GRF 1-29, significantly diminished the effect of GHRP-2 and GRF on cAMP accumulation and GH release, but did not affect GH release induced by GHRP-6. Somatostatin prevented cAMP accumulation and GH release responses to GHRP-2, GRF and GHRP-6. Ca2+ channel blockade did not affect the cAMP increase in response to GHRP-2 or GRF but totally prevented GH release in response to GHRP-2, GRF and GHRP-6. These results indicated that GHRP-2 acts on ovine pituitary somatotrophs to increase cAMP concentration in a manner similar to that of GRF; this occurs even during the blockade of Ca2+ influx. GHRP-6 caused GH release without an increase in intracellular cAMP levels. GH release in response to all three secretagogues was reduced by somatostatin and was dependent upon the influx of extracellular Ca2+. The additive effect of GHRP-2 and GRF or GHRP-6 suggested that the three peptides may act on different receptors. In rat pituitary cell cultures, GHRP-6 had no effect on cAMP levels, but potentiated the effect of GRF on cAMP accumulation. The synergistic effect of GRF and GHRP-6 on cAMP accumulation did not occur in sheep somatotrophs. Whereas GHRP-2 caused cAMP accumulation in sheep somatotrophs, it did not do so in rat pituitary cells. These data indicate species differences in the response of pituitary somatotrophs to the GHRPs and this is probably due to different subtypes of GHRP receptor in rat or sheep.

PMID: 8699133 [PubMed - indexed for MEDLINE]

 

[John Juan]

Gh peptides are a must for recovery if you are over the age of 30. I ache all over without extra HGH in my body.

 

[John Juan]

Ghrp6 really fills out your muscles while bringing out vascularity.

 

[C0LUMB0]

I have my personal training client on 125mcg GHRP6 and 100mcg cjc1295 no dac, prior to each meal. He has gained 5Lbs in two weeks and his strength is exploding!

what weight is your client ? does the cjc enhance the appetite stimulating effect of the ghrp or whats the synergy there bro ?

 

[John Juan]

what weight is your client ? does the cjc enhance the appetite stimulating effect of the ghrp or whats the synergy there bro ?

He weighs 223Lbs. He weighed 187Lbs when he started as my client 7 weeks ago.

Cjc doesn't increase appetite so much. It is synergistic with ghrp6 as it is a GHRH(growth hormone releasing hormone). GHRP6 is a growth hormone releasing peptide. They release human growth hormone via a different mechanism. For example, each taken alone releases x amount of HGH. When you stack them they release more than 2x HGH. It's more like 3x HGH. The two taken together release much more HGH than each taken seperately and the total HGH added together.

 

[C0LUMB0]

He weighs 223Lbs. He weighed 187Lbs when he started as my client 7 weeks ago.

Cjc doesn't increase appetite so much. It is synergistic with ghrp6 as it is a GHRH(growth hormone releasing hormone). GHRP6 is a growth hormone releasing peptide. They release human growth hormone via a different mechanism. For example, each taken alone releases x amount of HGH. When you stack them they release more than 2x HGH. It's more like 3x HGH. The two taken together release much more HGH than each taken seperately and the total HGH added together.

thanks for clearing that up , i could have googled it but i prefer to hear it from a genuine user .

 

[John Juan]

thanks for clearing that up , i could have googled it but i prefer to hear it from a genuine user .

You're welcome

 

[John Juan]

Blocked growth hormone-releasing peptide (GHRP-6)-induced GH secretion and absence of the synergic action of GHRP-6 plus GH-releasing hormone in patients with hypothalamopituitary disconnection: evidence that GHRP-6 main action is exerted at the hypothalamic level.

Abstract

GH-releasing peptide (GHRP-6; His-D Trp-Ala-Trp-D Phe-Lys-NH2) is a synthetic compound that releases GH in a specific and dose-related manner through mechanisms and a point of action that are mostly unknown but different from those of GHRH. In man, GHRP-6 is more efficacious than GHRH, and a striking synergistic action on GH release is observed when GHRP-6 and GHRH are administered simultaneously. Based on such a synergistic action, it has been hypothesized that GHRP-6 acts through a double mechanism by actions exerted both at the pituitary and hypothalamic levels. The aim of the present study was 2-fold: 1) to further characterize the mechanism of action and synergistic effects of GHRP-6; and 2) to study its action in patients with hypothalamopituitary disconnection. Twelve patients with different neuroendocrine pathologies leading to a state of hypothalamopituitary disconnection (functional stalk section) and 11 age- and sex-matched normal controls were studied. Each subject underwent 3 tests on separate occasions, being challenged with GHRH (100 micrograms, i.v.), GHRP-6 (90 micrograms, i.v.), or GHRH plus GHRP-6. GH was analyzed as the area under the curve (mean +/- SE, micrograms per L/120 min). In normal subjects GH secretion was 483.7 +/- 99.2 after GHRH, 1434.8 +/- 393.0 after GHRP-6, and 3771.5 +/- 399.6 after GHRH plus GHRP-6; the level of GH secreted after GHRH plus GHRP-6 treatment was significantly (P < 0.05) higher than after the arithmetic sum of GH levels after both compounds administered separately. In the group of patients with hypothalamopituitary disconnection, the level of GH secreted after GHRH was similar to that in controls (423.4 +/- 62.8); however, a complete blockade was observed after GHRP-6 (97.3 +/- 7.9), significantly (P < 0.05) lower than after GHRH as well as lower than the GHRP-6-induced GH release in control subjects (P < 0.01). After GHRH plus GHRP-6, the patients with hypothalamopituitary disconnection showed severely reduced secretion (745.3 +/- 67.6; P < 0.01 vs. controls), a value that was not significantly different from the arithmetic addition of levels produced by both compounds administered separately.

 

[John Juan]

Reasons to prefer GHRP-6 over other GHRP’s are its effect on increasing appetite, and its demonstrated value in reducing inflammation and helping to heal injury, particularly tendinitis.

 

[John Juan]

GHRP6 Reconstitution;

Add 2 1/2ccs of bacteriostatic water to the vial just as you would to any peptide by slowly dripping the bac water into the vial along the edge of the glass. Then slowly roll the vial in your hand until the powder fully goes into solution. If you have a 5 mg vial of GHRP6, then every single unit on the diabetic syringe will equal 20mcg of GHRP6. You will want to start with 5 units, or 100mcg.
If you have a 10mg vial of GHRP6 then only add 2ccs of bac water to the vial so that each unit will contain 50mcg of GHRP6. Take 2 units of solution to get 100mcg GHRP6.

GHRP's are fine to take with food, unlike it says in the literature, as long as you don't load up on simple carbs. Protein will not inhibit growth hormone release. The literature says fat inhibits GH release but this theory was shot down via serum HGH blood work a couple years ago. Only sugar intake will inhibit GH release from a GHRP and not fully. On the other hand, with a GHRH like cjc no dac or cjc DAC sugar will fully inhibit HGH release so try not to have simple carbs until 30 minutes after administering the GHRP/CJC peptide.

GHRP6 and CJC release HGH via a different mechanism. Stacking them together is synergistic and will increase HGH output way beyond the total HGH if you take each seperately. With cjcDAC it's not an issue as DAC is active for up to 16 days. With cjc no dac you want to take it at the same time as your GHRP for synergy.

 

[semper03]

So with everyone talking about the insane hunger gain you get from this, I take it that this wouldn't be the best things to take if you're wanting to lose some fat while gaining LBM?

 

[John Juan]

So with everyone talking about the insane hunger gain you get from this, I take it that this wouldn't be the best things to take if you're wanting to lose some fat while gaining LBM?

It would be very difficult to not over eat on GHRP6. GHRP2 releases more HGH but doesn't have quite as much of a hunger response. Ipamorelin doesn't have the hunger part at all and releases hgh for a longer duration but you need to dose it at around 300-500mcg and you need to stack it with cjcDAC or cjc no DAC to get the large release of HGH.

 

[C0LUMB0]

GHRP6 Reconstitution;

Add 2 1/2ccs of bacteriostatic water to the vial just as you would to any peptide by slowly dripping the bac water into the vial along the edge of the glass. Then slowly roll the vial in your hand until the powder fully goes into solution. If you have a 5 mg vial of GHRP6, then every single unit on the diabetic syringe will equal 20mcg of GHRP6. You will want to start with 5 units, or 100mcg.
If you have a 10mg vial of GHRP6 then only add 2ccs of bac water to the vial so that each unit will contain 50mcg of GHRP6. Take 2 units of solution to get 100mcg GHRP6.

GHRP's are fine to take with food, unlike it says in the literature, as long as you don't load up on simple carbs. Protein will not inhibit growth hormone release. The literature says fat inhibits GH release but this theory was shot down via serum HGH blood work a couple years ago. Only sugar intake will inhibit GH release from a GHRP and not fully. On the other hand, with a GHRH like cjc no dac or cjc DAC sugar will fully inhibit HGH release so try not to have simple carbs until 30 minutes after administering the GHRP/CJC peptide.

GHRP6 and CJC release HGH via a different mechanism. Stacking them together is synergistic and will increase HGH output way beyond the total HGH if you take each seperately. With cjcDAC it's not an issue as DAC is active for up to 16 days. With cjc no dac you want to take it at the same time as your GHRP for synergy.

I think there is a lot of confusion out there with regard to the units on a slin pin, some are marked from 10 - 100 and others are 1 -10 but either way there is still 100 units max.
there's a big difference in pulling 50 units as opposed to 5

 

[John Juan]

I think there is a lot of confusion out there with regard to the units on a slin pin, some are marked from 10 - 100 and others are 1 -10 but either way there is still 100 units max.
there's a big difference in pulling 50 units as opposed to 5

Exactly. Every time I try to explain it I cringe thinking someone will take 10x as much as they're supposed to do to misinterpretation of the diabetic syringe. It would be dangerous with some peptides to take 10x the correct dose.

 

[Elvia1023]

I think there is a lot of confusion out there with regard to the units on a slin pin, some are marked from 10 - 100 and others are 1 -10 but either way there is still 100 units max.
there's a big difference in pulling 50 units as opposed to 5

Someone did this very thing on our GHRP-2. He said he was shitting all day and night for 24 hours. Then you will not guess what he done the next day... he done the same amount again So after another day of feeling like utter shit he asked on the forum as he realized he had fucked up. Instead of 0.06ml (6 ticks) he took 0.6ml so well over 1mg GHRP-2 the very first time using it.

With the all the peps we sell and the different amount of water people add I don't think I have ever injected more than 0.1ml in one go. No one should ever be injecting most of the slin pin unless they are using AAS

 

[John Juan]

I just started GHRP2 at 150mcg 3x/day and my food comsumption has more than doubled. I'm hungry all the time. GHRP6 is even stronger at appetite stimulation. I can't even imagine that right now. Hahaha

 

[John Juan]

Ghrp6 is said to help tendinitis.

 

[Elvia1023]

I just started GHRP2 at 150mcg 3x/day and my food comsumption has more than doubled. I'm hungry all the time. GHRP6 is even stronger at appetite stimulation. I can't even imagine that right now. Hahaha

I am the same. My hunger on GHRP-2 is crazy so I couldn't imagine what GHRP-6 would do for me now. I am definitely gonna use GHRP-6 when bulking next

 

[John Juan]

I am the same. My hunger on GHRP-2 is crazy so I couldn't imagine what GHRP-6 would do for me now. I am definitely gonna use GHRP-6 when bulking next

I only ordered 2 vials of GHRP2 this month and it makes me very hungry. I'll get some GHRP6 next order and compare the two. My weight has gone from 196 to 241 since March. Maybe I'll hit 270. My all time high was 265Lbs.

 

[semper03]

With all that extra food how hard do you find it to keep the fat off? I seem to pack on fat in my lower abdomen and I bloat more when bulking. Just from diet alone no juice.

 

[John Juan]

With all that extra food how hard do you find it to keep the fat off? I seem to pack on fat in my lower abdomen and I bloat more when bulking. Just from diet alone no juice.

I'm on a lot of AAS so I gain mostly muscle and water. Being natural would definitely make it more difficult to stay lean while eating a lot, but the elevates HGH levels that GHRP6 gives you will build your body up while staying much leaner than you would without it. I definitely notice it makes me hot and I sweat a lot more so the metablism is faster causing much greater protein muscle synthesis.

 

[Elvia1023]

I'm on a lot of AAS so I gain mostly muscle and water. Being natural would definitely make it more difficult to stay lean while eating a lot, but the elevates HGH levels that GHRP6 gives you will build your body up while staying much leaner than you would without it. I definitely notice it makes me hot and I sweat a lot more so the metablism is faster causing much greater protein muscle synthesis.

Plus you train hard and for long periods. I haven't had many long workout recently... I miss my 3 hours workouts! I should add in no way do I recommend 3 hour workouts as it's too much but I just like doing them. If I were generalizing 1 hour would be optimal for most. I was just highlighting JJ is a fat burning machine due to his training and drugs

 

[John Juan]

Plus you train hard and for long periods. I haven't had many long workout recently... I miss my 3 hours workouts! I should add in no way do I recommend 3 hour workouts as it's too much but I just like doing them. If I were generalizing 1 hour would be optimal for most. I was just highlighting JJ is a fat burning machine due to his training and drugs

My long workouts have seized now that I'm bulking. I'm training only one muscle group per workout and hit it hard for an hour to 90 minutes, except on leg day which is two hours. Before my show I was doing up to 5 hour workouts inspired by Kai Greene. Now I'm just bombing one muscle group and eat eat eat ....

 

[John Juan]

If you want to put on quick mass and lean out this is the way to go. Stack it with cjcDAC for maximal HGH release.

 

[John Juan]

I just put a national level bodybuilder on GHRP6, 100 mcg every 3 hours before a meal with 500mcg cjcDAC before bed. He wanted a combination to put on the most mass possible in the shortest amount of time.

 

[John Juan]

Relationship between GHRP-6 and TPA in the regulation of growth hormone secretion by human pituitary somatotrophinomas.

AuthorsLiu Q, et al. Show all Journal
J Tongji Med Univ. 1997;17(3):132-5.

Affiliation
Abstract
Growth hormone releasing peptide (GHRP-6) is a synthetic hexapeptide which specifically stimulates secretion of growth hormone (GH) by pituitary somatotrophs. Phorbel ester, 1, 2 tetradecanoylphorbol 13 acetate (TPA) can also stimulate releasing of GH. The precise intracellular mechanism has not been entirely deciphered. We used cell cultures of human pituitary somatotrophinomas to investigate the relation between GHRP-6 and TPA on membrane phosphatidylinositol (PI) turnover and GH secretion. The results showed that the working mechanisms of GHRP-6 and TPA are not identical, although they all can stimulate GH secretion in human pituitary somatotrophinomas. This indicates that PI-PKC signal transduction system may play a crucial role in the regulation of GH secretion.

 

[John Juan]

GHRP6 has been proven to help tendinitis,

 

[Elvia1023]

GHRP6 has been proven to help tendinitis,

It will be my GHRP when I bulk next. Test, Deca, Adrol, CJC-DAC, GHRP-6 and LGD-4033 in that cycle... gonna be epic!!

 

[John Juan]

It will be my GHRP when I bulk next. Test, Deca, Adrol, CJC-DAC, GHRP-6 and LGD-4033 in that cycle... gonna be epic!!

I just reconstituted my last vial of GHRP2. I'm going to switch to GHRP6 when I'm out. I'm curious to see if our GHRP6 has a stronger appetite stimulation than our GHRP2 which is quite strong.

 

[John Juan]

There are more pubmed.com studies on the benefits of GHRP6 than any other ghrp since it was the first. Check out some studies there. Pubmed is a wealth of knowledge.

 

[Elvia1023]

There are more pubmed.com studies on the benefits of GHRP6 than any other ghrp since it was the first. Check out some studies there. Pubmed is a wealth of knowledge.

Yes loads of great info. Hexarelin is actually an analog of GHRP-6. Although for me they should be used for completely different things. GHRP-6 is all about gaining loads of size.

 

[John Juan]

Yes loads of great info. Hexarelin is actually an analog of GHRP-6. Although for me they should be used for completely different things. GHRP-6 is all about gaining loads of size.

It's craZy that hex comes from GHRP6 as GHRP6 makes me eat like a chick with cankles on cake, whereas hex just gives me a seriously head rush. Hahaha

 

[John Juan]

The way ghrp's work is this:

100mcg is known as saturation dose which means it releases 50% of the maximal HGH stores.
200mcg releases 75% maximal HGH stores
300mcg releases 87.5% maximal HGH stores
400mcg releases 93.75% maximal HGH stores
500mcg releases 96.875% maximal HGH stores

 

[John Juan]

MK-677 is essentially oral GHRP6

 

[chizzled77]

What would proper dosing for ghrp6 be? Does it have to be cycled?

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[John Juan]

What would proper dosing for ghrp6 be? Does it have to be cycled?

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Ghrp6 is typically stacked with cjc no dac 3x/day at 100mcg each subcutaneously injected. This protocol is the most common and gives the equivalent of 2ius of HGH per day and raises igf1 to up over 300 after one months time. If you dose it this way you can run it safely year round and reap all the benefits of elevated HGH including: fat loss, lean muscle gains, strength increase, younger looking skin, faster hair and nail growth, deeper sleep with more vivid dreams, reduced aging in general, increased appetite, etc. Some guys like me dose it higher in an attempt to get a greater HGH release but this will eventually down grade receptors meaning you will have to take one week off after a couple months to let receptors clean out.
Ghrp6 and cjc no dac( or cjc with DAC) work synergistically together. If ghrp6 gives you 2(in terms of hgh release ), and cjc no dac gives you 2, then running ghrp2 and cjc no dac together will give you more than 2 + 2. They will actually give you 7. The synergy by taking them together far out weighs the HGH release of taking each seperately.

 

[chizzled77]

So is Ghrp2 better than Ghrp6?
And cjc with no dac is better than with dac?

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[John Juan]

So is Ghrp2 better than Ghrp6?
And cjc with no dac is better than with dac?

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You can't really say one is better than the other as they each have their strengths.

Cjc no dac is a growth hormone releasing hormone that adds to the HGH pulse of a GHRP. They work synergistically to create a large HGH PULSE.

CjcDAC does the same thing as cjc no dac in terms of creating a synergistic HGH pulse, but it also causes the pituiitary gland to bleed HGH constantly when it's not pulsing. This produces more total HGH than cjc no dac but some people theorize it best to only have pulsatile HGH release like the body naturally does.

GHRP6 and GHRP2 both are ghreling memetic peptides.
GHRP2 makes you hungry.
GHRP6 makes you insanely hungry!!!
If stacked with either cjcDAC or cjc no dac, then both GHRP6 and GHRP2 release the same amount of HGH.
If run alone in high dose then GHRP2 is capable of releasing the most HGH.

 

[John Juan]

Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues

SUMMARY

Aging is associated with increased adiposity in white adipose tissues and impaired thermogenesis in brown adipose tissues; both contribute to increased incidences of obesity and type 2 diabetes. Ghrelin is the only known circulating orexigenic hormone that promotes adiposity.

 

[chizzled77]

Interesting ! I've been always wanting to get my hands on a real kit....but know i'm itching to try out ghrp and cgc.

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[Elvia1023]

Interesting ! I've been always wanting to get my hands on a real kit....but know i'm itching to try out ghrp and cgc.

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You should give them a go. If you are bulking GHRP-6 would be ideal (as would GHRP-2). If you are cutting and/or restricting calories then Hexarelin would be good as it won't stimulate your appetite. All of these can be run with either cjc. I prefer cjc-dac but both are fantastic.

 

[John Juan]

Interesting ! I've been always wanting to get my hands on a real kit....but know i'm itching to try out ghrp and cgc.

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There is so much garbage hgh out there right now. Ghrp2 and cjc give incredibly results. I would use pharma grade serostim, genotropin, or not even bother with hgh. GH peptides give you enough high quality HGH to really make progress in the gym.

 

[chizzled77]

Thanks for the knowledge fellaz

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[John Juan]

Thanks for the knowledge fellaz

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You're welcome! I love peptides. I'm bulking up and the ghrp/cjc is helpimg so much with my weight gain. Without it I wouldn't be able to eat enough. I weighed 196Lbs on March 15th when I competed . Last night I weighed 245Lbs.

 

[cmoney1000]

What's the dosing protocol for cjc with dac? How much per week? And is the gh bleed of any concern when running 3 month cycles? Thanks

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[John Juan]

What's the dosing protocol for cjc with dac? How much per week? And is the gh bleed of any concern when running 3 month cycles? Thanks

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Protocols vary. I like dosing it daily but that's not needed.

I just learned that Dennis James, trainer of Big Ramy, makes his clients take one 2mg vial of cjcDAC once a week.

The gh bleed offers mad fat loss and muscle recovery!
A 3 month cycle is perfectly safe IMO.

 

[John Juan]

i personally like any grhp for bulking but for someone who is a hard gainer with not so great appetite id say ghrp-6 is better

I agree. I get plenty hungry off GHRP2 , and I just started MK-677 which is a ghrelin mimetic and I feel enough hunger to get food down. But GHRP6 is king of the appetite stimulants.

 

[chizzled77]

Besides ghrp increasing appetite...how much would it help with the leaning out effect while bulking. I will be starting deca and test cycle end of july.


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[Elvia1023]

Besides ghrp increasing appetite...how much would it help with the leaning out effect while bulking. I will be starting deca and test cycle end of july.


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The huge gh spikes will help you stay lean whilst bulking and basically minimize any fat gain. Obviously diet is everything but when adding in gh boosters to aas the results can be incredible.

You can get other GHRP's that don't increase hunger such as Ipamorelin or Hexarelin. But in bulking cycles I would definitely go with GHRP-6 or 2 especially if you plan to eat big.

 

[Elvia1023]

What's the dosing protocol for cjc with dac? How much per week? And is the gh bleed of any concern when running 3 month cycles? Thanks

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I prefer to dose twice weekly and the more the better! So if you use 2mg per week then 1mg twice weekly and the same system for 4mg or even 6mg per week (1/2 Tues and Fri). CJC-DAC will make you shred fat and the results can be seen in days. 3 months is a nice amount of time and I see no safety concerns running it that long. Just make sure you have lots of time off too. 3 on 3 off 3 on would be a good system.

 

[John Juan]

I swear this MK-677 feels like I'm taking ghrp6 every couple hours. I'm starving!!!

 

[chizzled77]

Just placed an order for ghrp6 and cjc no dac woohoo.

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[Elvia1023]

Just placed an order for ghrp6 and cjc no dac woohoo.

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Good stuff. Let us know how you get on with everything. I put in a small order last night

 

[chizzled77]

Sure will.

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[Elvia1023]

Sure will.

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Try it on an empty stomach

 

[John Juan]

Just placed an order for ghrp6 and cjc no dac woohoo.

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Time to get huge! Better stock the refrigerator. Hahaha

 

[John Juan]

Definitely take GHRP6 on an empty stomach and once the mad hunger kicks in then feed like a savage. Make sure your refrigerator is fully stocked ahead of time.

 

[Elvia1023]

Definitely take GHRP6 on an empty stomach and once the mad hunger kicks in then feed like a savage. Make sure your refrigerator is fully stocked ahead of time.

I should add make sure you have no family sized tubs of ice cream as you will eat it all. For me family sized blocks of cheese will also be devoured. As will about 10 other things. Make sure you have lots of good nutritious food ready to be utilized

 

[chizzled77]

I should add make sure you have no family sized tubs of ice cream as you will eat it all. For me family sized blocks of cheese will also be devoured. As will about 10 other things. Make sure you have lots of good nutritious food ready to be utilized

Funny you mentioned it....i just recently broke away from a week long ice cream eating binge ....i was actually eating a whole 1.5 quart tub (sugar free) per day with whip cream on top. Dont know what came over me. Must have been a rebound effect from cutting cals too low I guess. Just glad my bf% has'nt gone up by much.

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[Elvia1023]

Funny you mentioned it....i just recently broke away from a week long ice cream eating binge ....i was actually eating a whole 1.5 quart tub (sugar free) per day with whip cream on top. Dont know what came over me. Must have been a rebound effect from cutting cals too low I guess. Just glad my bf% has'nt gone up by much.

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I have had a tub of Ben and Jerry's ice cream the last 3 days... and no GHRP-6 just pure greed Just adding you know you have a problem when you top of your ice cream with honey! By the way vanilla ice cream and honey is amazing!

 

[John Juan]

I have had a tub of Ben and Jerry's ice cream the last 3 days... and no GHRP-6 just pure greed Just adding you know you have a problem when you top of your ice cream with honey! By the way vanilla ice cream and honey is amazing!

I've never tried ice cream with honey on top. That sounds great!!! Will have to try it after a 400mcg injection of GHRP6.

 

[chizzled77]

Im getting that urge to buy a tub again. Lol

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[John Juan]

Im getting that urge to buy a tub again. Lol

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Hahaha just mentioning it makes me crave things. Hahaha I've only had protein and fats this morning so sugar sounds dank.

 

[John Juan]

Epidermal growth factor and growth hormone-releasing peptide-6: combined therapeutic approach in experimental stroke.

AuthorsGarcía Del Barco-Herrera D, et al. Show all Journal
Restor Neurol Neurosci. 2013;31(2):213-23. doi: 10.3233/RNN-120262.

Affiliation
Abstract
PURPOSE: Stroke is the second cause of mortality worldwide, with a high incidence of disability in survivors. Promising candidate drugs have failed in stroke trials. Combined therapies are attractive strategies that simultaneously target different points of stroke pathophysiology. The aim of this work is to determine whether the combined effects of epidermal growth factor (EGF) and growth hormone-releasing peptide-6 (GHRP6) can attenuate clinical signs and pathology in an experimental stroke model.

METHODS: Brain global ischemia was generated in Mongolian gerbils by 15 minutes of carotid occlusion. After reperfusion, EGF, GHRP6 or EGF+GHRP6 were intraperitoneally administered. Clinical manifestations were monitored daily. Three days after reperfusion, animals were anesthetized and perfused with an ink solution. The anatomy of the Circle of Willis was characterized. Infarct volume and neuronal density were analyzed.

RESULTS: EGF+GHRP6 co-administration reduced clinical manifestations and infarct volume and preserved neuronal density. No correlation was observed between the grade of anastomosis of the Circle of Willis and clinical manifestations in the animals receiving EGF+GHRP6, as opposed to the vehicle-treated gerbils.

CONCLUSIONS: Co-treatment with EGF and GHRP6 affects both the clinical and pathological outcomes in a global brain ischemia model, suggesting a suitable therapeutic approach for the acute management of stroke.

 

[John Juan]

The hunger on ghrp6 is overwhelming at times!!!

 

[John Juan]

If you are trying to put on mass quickly, I would say GHRP6 stacked with cjc1295 is the best route to go.

 

[John Juan]

I would highly agree, anadrol and a few other compounds destroy my appetite, add ghrp-6 and boom im eating like a cow again

My body is weird. Anadrol makes me hungry but dbol makes me nauseas depending on the brand. In inject form both anadrol and dbol give me no sides.

 

[John Juan]

Time to buy GHRP6 while it's on BOGO.
Follow the instructions in my signature for the deal.

 

[Elvia1023]

I've never tried ice cream with honey on top. That sounds great!!! Will have to try it after a 400mcg injection of GHRP6.

It is amazing. I had a little bowl before. Definitely try it. Even better if you get the new protein ice cream. You could make it yourself but there is a new product out over here and the macros are decent. Most importantly it tastes like ice cream but is full of whey protein. I just use normal ice cream though I saw a Remy Martin Champagne Cognac Ice cream the other day I will be trying too!

 

[John Juan]

It is amazing. I had a little bowl before. Definitely try it. Even better if you get the new protein ice cream. You could make it yourself but there is a new product out over here and the macros are decent. Most importantly it tastes like ice cream but is full of whey protein. I just use normal ice cream though I saw a Remy Martin Champagne Cognac Ice cream the other day I will be trying too!

Hahaha that sounds fancy.

 

[John Juan]

I just talked to a national level bodybuilder who I put on ghrp6 and cjc no dac 3x/day. He just competed and has been cruising since his show on only 200mg testosterone and 100mcg ghrp6 with 100mcg cjc no dac 3x/day. He said guys think he is still blasting high dose gear. His weight is 15Lbs higher than it usually is on a cruise and he is maintaining contest condition. This peptide combo is amazing!!