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Zoloft for fatloss!

A lot of AD's will kill your appetite, but 50lbs in a month, something seems wrong there. I'd definitely be interested in hearing if there is any legitimacy to using Zoloft as a fat loss drug. It seems like the sides might be scarier then those associated with DNP. Mainly because Zoloft messes with your brain-chemistry, I'm not sure how it would affect people that normally wouldn't need to use the drug, especially with such high doses.
 
Many people report they initally report loss of appetite and some weight loss when they begin taking SSRIs. However after a few months most people report gaining back the weight and then some. Over extended periods of time most people report gaining 15+ lbs. I believe seritonin is produced from glucose as are most, if not all, neurotransmitters. This is one reason why the body likes to burn carbs before fat-Carbs breakdown to glucose easier and faster than fat leading to faster neurotransmitter production which makes your brain happy. Damn the human body is cool!

So if your SSRI meds are working your brain is picking up the seritonin it wasn't before which may cause your appetitie to decrease (you need less glucose to fuel seritonin production). People probably gain weight over time because their bodies adapt to the external medication and shutdown internal processes. Most patients need to increase SSRI dosage over time (since their bodies have adapted to the external SSRI meds), but an increase in glucose intake will have the same affect. Your body doesn't really crave drugs as much as cake so eat more cake and you're happy.

The moral of this tale>Zoloft or any SSRI administration will just lead to weight gain by direct order of your brain.

FHG
 
Zoloft is not Zyban. WellbutrinSR is Zyban.

The precursor for serotonin is tyrosine, not glucose. But you're right about carbs stimulating a brief release of serotonin causing transient mood elevation, followed by crash. Many of the SSRI's do have a stimulating, weight loss/loss of appetite effect during the first week or two, followed by longer term weight gain (average of 5-10#). The mech has to do with satiety and also with the degree to which the particular drug affects histamine receptors (not sure of the details there.)

And taking the SSRI's when you're not depressed will do little other than to kill your sex drive, decrease you ability to achieve an erection/ejaculate/have an orgasm, clench your teeth, and some other annoying things.
 
Ceps-
Thanks for the details. I figured I had the basics down. By "satiety" do you mean satisfaction like similar to eating a godd meal and being satisfied?. I'd like to hear more about the histamine receptors and the role they play in the weight gain if you have time.

FHG
 
FHG:

You're welcome. By satiety I mean the sensation of being full, or having eaten enough. It's complex because it would also involve stomach stretch receptors and lots of psychosocial factors. I'd have to look into the histamine receptors and weight gain. What I know is that meds (in particular the antidepressants) that affect histamine in the brain cause sedation and weight gain. I'm not sure how much is from dysregulation of satiety, slowing metabolism, or some other mechanism.
 
Kingjohn:

Zoloft is sertraline.
Wellbutrin is bupropion.
Zyban is bupropion.

Insurance usually doesn't cover Zyban, but will cover Wellbutrin if the doctor says it's being prescribed for depression and not to replace Zyban for smoking cessation. Bupropion and sertraline are both anti-depressants. They are not the same drug. They affect different neurotransitter systems, have different mechanisms of action, and different side effect profiles. If your doctor thinks Zoloft and Zyban are the same drug I'd look for another doctor. Nobody knows everything, but half of being smart is knowing what you don't know.
 
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