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Winny/Stanozolol and real medical research.

AlbinoRhino

New member
Hey guys I had posted earlier that I would like to live the unhealthy life style of a weekend binge drinker while taking WInny. I was looking for factual information that used real medical documentation citing the true liver toxicity of Winny and how severe the true risks were.

To summarize a day on Google, there isn't any good facts stating damage to your liver. There is more of a medical assumption that because of the way it binds to certain receptors in your body and how many times it passes through your liver that damage may occur. No proof though due to the limitations placed on high dosage clinical tests and laws of Ethics imposed by the FDA. Their was proof however, that your HDL and LDL level will indeed suffer. High cholesterol will also play a decent factor. Below are the "best of" resource documentation available through googling.


Hereditary angioedema : Safety of long-term stanozolol therapy
A dose of .5-2mg per day orally over 20-40 years with minimal side effects. With BB's pension for high doses this isn't that great other than identifying that low dosage has positive effects and does not do long term dmg.

STANOPLEX 10 (STANOZOLOL) -
Great overview on the drug without too many medical terms or statistics

New 'Breakfast of Champions': A Recipe for Victory or Disaster? - New York Times
Good read from NY times, has specific reference in the use of stanazolol below is the part you will care to read:

The Oct. 22 issue of the British Medical Journal reported a surprising and provocative finding that strongly hints for the first time that anabolic steroids can increase the size of one type of muscle fiber, even without training. The finding involved stanozolol, the anabolic steroid that was detected in Ben Johnson's urine after he set a world record in winning the Olympic 100-meter dash and that led to his expulsion from the Olympics.

Dr. Janice L. Hosegood and Dr. Antony J. Franks reported that they had given stanozolol to eight volunteers for 14 to 21 days before elective surgery at the University of Leeds. Biopsies - small pieces of an abdominal muscle - were taken at the beginning of the operation and later examined under the microscope. The researchers also studied samples of the same muscle from eight additional volunteers, who did not get stanozolol before surgery.

Among those treated, stanozolol increased the size of the endurance, or Type I, muscle fibers in the abdominal muscle studied. These fibers typically tend to increase after arduous long term exercise. Stanozolol did not affect the size of the Type II fibers, which typically bulk after strength-building exercise.

Dr. Franks and others said they were surprised by the findings because the abdominal muscle studied was one not used in exercise, the fibers within it enlarged without training, and the Type I fiber is not the one his team and most other experts would have predicted would enlarge. Some Hazards Are Documented


http://www.unitedpharmacy.net/s_vet/vet_misc.htm
bottom of the page sates clinical trials in sled dogs. good stuff

ANABOLIC STEROID USE IN BRITAIN study od AAS in britain.
Alot of statistics I found interesting. Things such as the insane cocktails some of Brits AAS users are doing and are still alive.

Hope some of this helps our other beginners and noobs who are out there fact searching.
 
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You can find a lot of stuff with google. But you also get the trash. To just check out medical journals you should use Pubmed: NCBI HomePage

This will give you everything published in peer reviewed journals going back, in some cases, to the fifties.
 
Stimulation of collagen synthesis by the anabolic ...[J Invest Dermatol. 1998] - PubMed Result

There is evidence that anabolic steroids, which are derived from testosterone and have markedly less androgenic activity, promote tissue growth and enhance tissue repair; however, the mechanisms involved in their anabolic activities remain unclear. In this report, we measured the effect of the anabolic steroid stanozolol on cell replication and collagen synthesis in cultures of adult human dermal fibroblasts. Stanozolol (0.625-5 microg per ml) had no effect on fibroblast replication and cell viability (p = 0.764) but enhanced collagen synthesis (p < 0.01) in a dose-dependent manner (r = 0.907). Stanozolol also increased (by 2-fold) the mRNA levels of alpha1 (I) and alpha1 (III) procollagen and, to a similar extent, upregulated transforming growth factor-beta1 (TGF-beta1) mRNA and peptide levels (p < 0.001). There was no stimulation of collagen synthesis by testosterone. The stimulatory effects of stanozolol on collagen synthesis were blocked by a TGF-beta1 anti-sense oligonucleotide, by antibodies to TGF-beta, and in dermal fibroblast cultures derived from TGF-beta1 knockout mice. We conclude that collagen synthesis is increased by the anabolic steroid stanozolol and that, for the most part, this effect is due to TGF-beta1. These findings point to a novel mechanism of action of anabolic steroids.

This and other studies indicate winny increase procollagen 1 (hair, fingernails, skin) and procollagen 3 (tendon, ligament, cartilage) substancially and ultimatley are beneficial for wound healing.
 
Bro, you need to remove the axio link. Read the rules, that is not okay.

Just copy and paste the article/review into your post.


Very interesting reading though. I like the solid medical info. good stuff!
 
Stimulation of collagen synthesis by the anabolic ...[J Invest Dermatol. 1998] - PubMed Result

There is evidence that anabolic steroids, which are derived from testosterone and have markedly less androgenic activity, promote tissue growth and enhance tissue repair; however, the mechanisms involved in their anabolic activities remain unclear. In this report, we measured the effect of the anabolic steroid stanozolol on cell replication and collagen synthesis in cultures of adult human dermal fibroblasts. Stanozolol (0.625-5 microg per ml) had no effect on fibroblast replication and cell viability (p = 0.764) but enhanced collagen synthesis (p < 0.01) in a dose-dependent manner (r = 0.907). Stanozolol also increased (by 2-fold) the mRNA levels of alpha1 (I) and alpha1 (III) procollagen and, to a similar extent, upregulated transforming growth factor-beta1 (TGF-beta1) mRNA and peptide levels (p < 0.001). There was no stimulation of collagen synthesis by testosterone. The stimulatory effects of stanozolol on collagen synthesis were blocked by a TGF-beta1 anti-sense oligonucleotide, by antibodies to TGF-beta, and in dermal fibroblast cultures derived from TGF-beta1 knockout mice. We conclude that collagen synthesis is increased by the anabolic steroid stanozolol and that, for the most part, this effect is due to TGF-beta1. These findings point to a novel mechanism of action of anabolic steroids.

This and other studies indicate winny increase procollagen 1 (hair, fingernails, skin) and procollagen 3 (tendon, ligament, cartilage) substancially and ultimatley are beneficial for wound healing.

Interesting paper.

Most of the lads say winnie is hard on the joints, and one of the common sides in women is hair loss and brittle fingernails, which would mean inhibited collagen synthesis.

I think the issue is that it is in tissue culture.

Cells in tissue culture are a great starting place for some research, but they are really quite messed up as far as cells go.

They have to do all sort of odd things to them to keep them alive, and a lot of cultures are derived from cancerous cells so they will keep replicating even though they have lost their contact inhibition.

It does seem like this may be one of those situations where what happens in vitro (test tube) doesn't happen in vivo (the body).

It does make you wonder if it would work if it was in much lower doses, as they were working in micrograms.
 
At what price, glory? Severe cholestasis and acute renal failure in an athlete abusing stanozolol.

Here is a case study of severe cholestasis (bile duct obstruction, liver damage) and kidney failure in someone abusing stanozolol.

Rare - but possible.

Great follow up posts guys. This has been my first foray into researching medical documentation and case studies so I only knew to search Google. The new links are nice.

Also thank you to the admin who removed my link, I didn't even think about it when I posted it as a source for information =( Buying online just scares me too much so I never consider it.

If anyone read the link that Bill posted up for us there is some very interesting information in there. Specifically, it states two items: The first being that the guy using Stanazolol was injecting 125mg 2X per week which doesn't appear to follow the popular methods recommended by the original manufacturer OR cycles posted by users online. Also he was using only 250MG a week as to where the popular dosage recommended seems to be 50MG every day, which comes out 100mg over what he was using. He was also injecting which people online have reported produces less strain on someones liver as it only passes through it 1 time. Yet he still had liver failure. That is something serious to consider.

On the other hand there is point number 2. Quote: "To our knowledge this is the first report of severe cholestasis and acute renal failure in an athlete using anabolic steroids". So this is somewhat like an individual getting hives from taking aspirin. It is a rare but dangerous potential case that we should all be aware of when taking these risks.
 
As my first post on these boards let me add to this research thread.

ANABOLIC STEROIDS

Here is an article on the usage of anabolic steroids on "wasting" (loss of muscle mass, bone density etc) in AIDS patients. So here you have people in *terrible* physical condition who are incapable of pumping iron, yet they are helped by steroids.

One of the options proven to be effective is oral Stanozolol, dosed 6-18mg per day in men and 4-12mg in women, with the higher doses being used in cases of severe wasting. This clearly is contrary to popular belief among bodybuilders thats such doses are useless.

What would you think of a "roid cycle" of 35mg test shots once a week? Utterly useless? Still, for the average man that's all the testosterone his body supplies him with. Think about that when you're getting jabbed with 700.
 
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