As Montana said, if it is water based every day, but if you want to get technical about it it depends on the degree of micronization of the crystals. Larger crystals will slow the release but either way it is best to go ED. I still marvel at how popular this steroid is considering it's performance record and results. Oh well, at least it is cheaper now days then when I used to marvel about it. Upjohn Winny-V=waste of my money.