Why was Boldenone never used for human consumption throughout history?

[Mavy]

Can anyone tell me why Boldenone has never made it to the human market? I think that someone poster 1 study where it was tested on humans before, cant remember by who or why.

I dont understand? Its such a great drug in my opinion. I am thinking that it has never made it because EQ is almost identicle to d-bol. The only difference is EQ has been 17 beta esterfied while d-bol has been 17 alpha alkylated.

This small change makes the two hormones act very differently in the body, but makes dbol much more effective, maybe that is why it has never made it to the human market? No need for it because dbol will do the job better? Well EQ is NOT liver toxic at sane doses where dbol is. You would think that that would be a selling point right there.

Also, I am thinking that there are just to many other things out there, ... dbol, test, var, primo, deca, adrol, winny, and they just really do not need it. But why do they feel horses need this so much when there are all those other choices out there? I am just curious what makes this compound so great for horses, but not great enough for people that it has never been made for the human market? Any thoughts?

Mavy

 

[georgie24]

cause anxiety bro

 

[Mavy]

There is no actual proof this georgie, (mind you this is probably because there are very few studies done on human consumption) And further more this is something that is more of an "urban legend" amongst bodybuilders that has passed on through time and use.

 

[NJjuice22]

here's my guess...look at what most steroids are used for, hormone replacement therapy or for wasting diseases, i dont think equipose would have much use for either, it used in animals because it increases muscle endurance and slight lean muscle gains.....that could be why, no real benefit to people other than athletes looking for an edge, and steroids are not produced for that...legally atleast.

 

[jerkbox]

how come dbol aromatizes and boldenone doesn't if they are so similar?

not being a prick here, asking a serious question.

 

[GoldenDelicious]

here's my guess...look at what most steroids are used for, hormone replacement therapy or for wasting diseases, i dont think equipose would have much use for either, it used in animals because it increases muscle endurance and slight lean muscle gains.....that could be why, no real benefit to people other than athletes looking for an edge, and steroids are not produced for that...legally atleast.

correct

 

[lartinos]

here's my guess...look at what most steroids are used for, hormone replacement therapy or for wasting diseases, i dont think equipose would have much use for either, it used in animals because it increases muscle endurance and slight lean muscle gains.....that could be why, no real benefit to people other than athletes looking for an edge, and steroids are not produced for that...legally atleast.

but isn't deca prescribed?

 

[lartinos]

how come dbol aromatizes and boldenone doesn't if they are so similar?

not being a prick here, asking a serious question.

bold does aromatize

 

[argent]

jut not as much

 

[Judo Tom]

and dbol marmotizes into a methylated estrogen which is much stronger so the small amount that amortizes has greater effects

 

[Judo Tom]

also wouldnt eq be pretty good for aids patients because it would make them eat more???

 

[argent]

and dbol marmotizes into a methylated estrogen which is much stronger so the small amount that amortizes has greater effects

I am not so sure of this methylated estrogen thing dude.

 

[Big Rick Rock]

also wouldnt eq be pretty good for aids patients because it would make them eat more???

There are other things outhere to help with appetite, I don't think thats a good reason to prescribe an AS.

 

[Little Rage]

Mavy:
anxiety on eq is an "urban legend?" That's almost funny

 

[TheRide]

cause anxiety bro

Can be a side-effect... but not in everyone. Never happened to me for example...

 

[TheRide]

Mavy:
anxiety on eq is an "urban legend?" That's almost funny

Again... anx. is a possible side-effect. Much like acne, gyno, hair loss. Some people are prone, others are not.

 

[LeanforLife]

EQ anxiety is how I lost my gf and considered taking my life. It's the compound that made me stop AS for good.

 

[Judo Tom]

I am not so sure of this methylated estrogen thing dude.

eq armotizes into estrogen at some %

dbol armotizes into a methylated estrogen because dbol is methylated eq

this is not the best scientific type answer but it is true that the estrogen that dbol amortizes into is MUCH stronger than the estrogen test or eq metabolizes into..

 

[Judo Tom]

There are other things outhere to help with appetite, I don't think thats a good reason to prescribe an AS.

but lots of aids patients are on roids anyway to prevent muscle wasting anyway..

i am not sure how anti-catabolic eq

 

[Nucman]

EQ anxiety??

Is it like Tren anxiety? At 1st Tren gave me a little anxiety. For those who have done both, is it better or worse than Tren anxiety?

 

[Little Rage]

TheRide:
I agree that is a side effect. so then calling it an urban legend is inaccurate.

 

[argent]

eq armotizes into estrogen at some %

dbol armotizes into a methylated estrogen because dbol is methylated eq

this is not the best scientific type answer but it is true that the estrogen that dbol amortizes into is MUCH stronger than the estrogen test or eq metabolizes into..

The methyl group is chemically attached to a compound to make it orally active. The methyl group gets cleaved off in the process of your body using it.

I don't think the human body is capable of adding methyl groups to estrogen. By your rationale, testosterone propionate would aromatize to estrogen propianate which we know to be untrue.

 

[JuicePimp]

EQ is not like tren. EQ seems to be very mild in terms of sides for most. But I get no anxiety on EQ. Or on tren.

Does paranoia that the cops are comming count?

 

[Judo Tom]

The methyl group is chemically attached to a compound to make it orally active. The methyl group gets cleaved off in the process of your body using it.

I don't think the human body is capable of adding methyl groups to estrogen. By your rationale, testosterone propionate would aromatize to estrogen propianate which we know to be untrue.

read this:
pasted from http://www.anabolicextreme.com/anabolic/archives/anex_archives_issue10_structure.htm

Dianabol vs. Equipoise
Many claim that Equipoise (boldenone) does not aromatize or give estrogenic side effects, but that dianabol does. This is interesting, because the two molecules are strikingly similar. In fact, at the A ring (where aromatization takes place), they are identical. The only differences are at the D ring. The "R" in the Boldenone molecule is shorthand for a carbon chain (in this case, undecylenate).



Why, then, does Dbol give side effects that Equipoise does not? First, the 17-alpha methyl group affects the way the liver functions, and certain growth factors may be released. Second, the Dbol may actually develop higher concentrations in the blood (spikes right after the pills are taken), and give a higher rate of aromatization than Boldenone. The Boldenone will not give a spike in concentration, since the liver very effectively deactivates it in one pass, and it is released slowly from the ester "depot". The spikes of high concentration of Dbol can give a higher Estradiol concentration over time because the estrogens are not deactivated as quickly as the androgens are in the liver. In fact, the estrogen that will form from Dbol is the 17-alpha mentholated estradiol, which is likely to stay in the system for a long time, because the liver will have a very hard time degrading it. So, the estrogen level can build up over time with the use of Dbol.

 

[geoboy]

Again... anx. is a possible side-effect. Much like acne, gyno, hair loss. Some people are prone, others are not.

the anxiety is probably due to revving up metabolism which explains leaning effect, insomnia & appitite increase as well.

i'm an ecto and experienced the anxiety/insomnia effect before i knew about the urban legend so its not placebo.

iow the urban legend is an urban legend, not the anxiety.

 

[Mavy]

Mavy:
anxiety on eq is an "urban legend?" That's almost funny

Little Rage, can you please explain this to me ... exactly how boldenone causes anxiety? I would like to know you "reasoning" behind this. I am not going to get into this debate again .... its has been played to death! Some believe it is real, others dont. Others believe its real, but cannot explain 1 reason why.

How can you say that its EQ that causes anxiety in general, and not AAS altogether? What does EQ have in it that would cause this over dbol, test, deca, adrol ... please explain this to me?

ANd please dont say "because its vet gear". Then tell me why dont QV Deca or Enanthate cause these symptoms? They are all vet gear.

One of the biggest reasons I can think of that was mentioned before by someone, is that hormones influence neurotransmitter levels in the brain. Testosterone and its derivatives have a very well established positive correlation with dopamine. When dopamine levels are influenced, this effects neurotransmitter "balance". High dopamine can lead to aggressiveness, anxiety, paranoia, rapid heartbeat, etc. But why then would EQ influence this more than test or dbol, or deca? What makes boldenone have a greater influence?

Increased blood volume and high blood pressure could explain the anxiety attacks as well ... but again there are other drugs that take much more of a toll on your BP, yet the anxiety issue is not associated with these drugs. I would just like you to explain to me why this happens? Thats all. Im not doubting it, I just cant see why people blame this on boldenone, and not aas in general? I personally have never felt anxiety off of EQ, and it is included in most of my cycles. Again , thats not to say it dosent exist (i guess??). I am just more or less looking for an answer why bold would cause it more than other aas.


You see you would be surprised how strong believe something when they are expecting it. The placebo effect is very real my friend.

Sure ... a few people have a few anxiety attacks before (that probably took them before taking EQ anyways), blamed it on the EQ. Then others here of this and are always weary of this when they take there cycle (paranoid). Anything that makes them feel anxious will be blamed on the EQ. Over a long period of time, this reputation becomes associated with EQ. This reputation along with the high hormone levels, extra stress put on your body and whatever else you are on at the time seem to be good ingredients for these anxiety attacks.

Believe what you want, but I doubt that you cannot put up a legit explanation of how boldenone causes this because most of the docs and vets on this board cant either. It has been debated many times.

Regardless of if you think its real, or not, or just a side-effect. It still dosent answer my question to why it has not made it to the human market? Think about it ... there are tuns of other steroids and drugs out there with much worse sides than EQ and are available on the human market.

Mavy

 

[SwolK]

Leanforlife. im sorry to here that bro

 

[Mavy]

I dont think that you should rule out your mind as being responsible ... any more than any other hypothesis. Like I say ... placebo is a real thing.

Doctors in one study successfully eliminated warts by painting them with a brightly colored, inert dye and promising patients the warts would be gone when the color wore off. In a study of asthmatics, researchers found that they could produce dilation of the airways by simply telling people they were inhaling a bronchiodilator, even when they weren't. Patients suffering pain after wisdom-tooth extraction got just as much relief from a fake application of ultrasound as from a real one, so long as both patient and therapist thought the machine was on. Fifty-two percent of the colitis patients treated with placebo in 11 different trials reported feeling better -- and 50 percent of the inflamed intestines actually looked better when assessed with a sigmoidoscope ("The Placebo Prescription" by Margaret Talbot, New York Times Magazine, January 9, 2000)

 

[Mavy]

EQ anxiety is how I lost my gf and considered taking my life. It's the compound that made me stop AS for good.

LeanforLife,

That is terrible to here, and I am sorry about that. But how can you really blame it on the EQ. How do you not know it wasnt just the events that were going on in your life? How do you know it wouldnt have happened if you were taking tren, abombs or test for example?

 

[Mavy]

Getting back to the original post, Seth Roberts dug up the only journlal entry he could find, and that I have ever seen anyone post regarding boldenone for human consumption. Can someone with medline access PLEASE post this link? I have been dying to read it. It very well could have some answers in it. I would be very interested to read this.



Re: boldenone in humans


quote:
--------------------------------------------------------------------------------
Originally posted by Seth Roberts
This was the only reference that I could find on short notice for the study of boldenone in humans -- Parenabol is a trade name for boldenone undecyclenate.
Seth




The effect of "Parenabol" on patients with osteoporosis.

Melick RA, Baird CW.

PMID: 5493340 [PubMed - indexed for MEDLINE]
--------------------------------------------------------------------------------

 

[Little Rage]

Mavy:
regarding your original question: I agree to what you said in an older post. i don't feel this is a market for it: there are other similar drugs to it (nandrolone and primo). and i don't think the reason that it increase hunger would be a reason to use it for humans, b/c hey that's a myth too


Regarding the anxiety issue:
i completely agree that with many it is a placebo effect, but there are the cases of people having no previous knowledge of a possible increase of anxiety with its usage; and it does affect these people.

There have been reports of people getting anxiety from other substances too, such as tren and even test. Now it could be due to previous anxiety problems, a placebo effect, or just attributed to events causing anxiety in their life.

I personally have noticed an increase in anxiety with just about every type of gear i have used: though to different degrees. I have had anxiety problems before i started to use gear and it has continued while off cycle. I was ready for a slight increase in anxiety with eq, but it put me in a complete wreck at times. Then i tried tren, i was ready for anxiety to knock me on my ass b/c of its anxiety myths. However i experienced 0 to minimal increase in anxiety, and 2 bad attacks lasting about 5min. when i was on eq, my anxiety attacks lasted up to 1:30 HOURS!!! Now i'm not ignorant and won't deny that some of my anxiety is due to personal reasons and such, but i have never had an anxiety attack lasting over 15min or so. And when on eq, an attack of 45min-1hr was not uncommon. They were even in the range of 6-12 a week (i believe i had 15 in 3 days).



I came across your original post on this: fukkenshredded added his insight to this:
"EQ stimulates erythropoiesis, which can lead to high BP very quickly and anxiety can result from this alone.

Increased blood volume explains both anxiety as well as increased appetite. Its not across the board, but will affect many this way more often than not."



I also came across this study from a previous post:

Although the study does not deal with EQ specifically, I would be surprised if it did not have the same anxiety inducing effects as the other drugs.

It is also thought that anabolic steroids also act on the body's natural opioid system to somehow induce anxiety and aggressiveness.



The abstract shows that certain anabolic steroids increase the metabolism of serotinin, leading to low levels of serotonin in the body. This could be responsible for the anxiety felt by many steroid users, as well as for "roid rage" ( I personally think that a jerk will remain a jerk, and a mellow person will remain mellow on steroids.) It is particularly interesting that anadrol was the only agent to raise monamine oxidase levels. This is a key enzyme responsible for metabolizing serotonin. Anandrol is notorious for increasing aggression.

Br J Pharmacol 1999 Mar;126(6):1301-6

Increased dopaminergic and 5-hydroxytryptaminergic activities in male rat brain following long-term treatment with anabolic androgenic steroids.

Thiblin I, Finn A, Ross SB, Stenfors C.

Department of Forensic Medicine, Karolinska Institute, Stockholm, Sweden.

1. The effects of treating groups of rats with four different anabolic androgenic steroids (AAS) (testosterone, nandrolone methandrostenolone, and oxymetholone) on 5hydroxytryptamine (5-HT) and dopamine (DA) neurones in different brain regions were examined. The AAS was injected six times with 1 week's interval and the rats were sacrificed 2 days after the final injection. 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA), DA and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were measured. The effect on DA and 5-HT synthesis rate was analysed as the accumulation of 3,4-dihydroxyphenyl-alanine (DOPA) and 5-hydroxytryptophan (5-HTP), respectively, after inhibition of the amino acid
decarboxylase with NSD-1015 (3-hydroxy-benzylhydrazine dihydrochloride). Additionally, the monoamine oxidase (MAO) activity was analysed in the hypothalamus. 2. The DOPAC + HVA/DA ratio was increased in the striatum in all treatment groups. However, the synthesis rate of DA was significantly increased only in the methandrostenolone treated group. 3. The 5-HIAA/5-HT ratio was increased in all treatment groups in the hippocampus, in the frontal cortex in the methandrostenolone-treated animals and in the hypothalamus in the testosterone- and oxymetholone-treated rats, while the 5-HT synthesis rate was not affected by the AAS-treatments. 4. The MAO-A activity was increased in the oxymetholone-treated rats while the other treatment groups were unaffected. The MAO-B activity was not changed. 5. The results indicate that relatively high doses of AAS increase dopaminergic and 5-hydroxytryptaminergic metabolism in male rat brain, probably due to enhanced turnover in these monaminergic systems





Anyway you look at it, I don't think we will have a definite explanation of this for a long time... if ever.

 

[Mavy]

Good study Little Rage. But ... neither studies isolate boldenone to be the cause of this. Dbol gives a sense of well being due to the positive nitrogen balance it creates. Adrol increases agression due to the raise in monamine oxidase levels. Nothing is directly linked to boldenone though.

I guess that its not fair to say that it dosent happen because there is no proof of this ... because there really hasnt been any research done on it. If the effects of boldenone were studied on humans as much as the other aas, maybe we would see something that would link EQ to anxiety more so than other aas would.

I hate hearing these stories, because I am going to be thinking about them when I am on my EQ cycle in 1 month, and it will be playing mind games with me! hhehe!

Mavy

 

[Mavy]

Re: boldenone in humans


quote:
--------------------------------------------------------------------------------
Originally posted by Seth Roberts
This was the only reference that I could find on short notice for the study of boldenone in humans -- Parenabol is a trade name for boldenone undecyclenate.
Seth




The effect of "Parenabol" on patients with osteoporosis.

Melick RA, Baird CW.

PMID: 5493340 [PubMed - indexed for MEDLINE]
--------------------------------------------------------------------------------

Bump for someone to post up this study.

 

[genarr3]

Mavy:
regarding your original question: I agree to what you said in an older post. i don't feel this is a market for it: there are other similar drugs to it (nandrolone and primo). and i don't think the reason that it increase hunger would be a reason to use it for humans, b/c hey that's a myth too
I think Litttle Rage got it here. Very little upside for a Pharmaceutical company to go to the touble having human trials and getting approved by the FDA when there are so many other drugs that do basically the same thing. The cost won't justify the possible profit.

 

[Mavy]

Im sure thats it gennar. Just makes you wonder why it was never put out when the rest of them were.

 

[big_boy_1]

Can anyone tell me why Boldenone has never made it to the human market? I think that someone poster 1 study where it was tested on humans before, cant remember by who or why.

I dont understand? Its such a great drug in my opinion. I am thinking that it has never made it because EQ is almost identicle to d-bol. The only difference is EQ has been 17 beta esterfied while d-bol has been 17 alpha alkylated.

This small change makes the two hormones act very differently in the body, but makes dbol much more effective, maybe that is why it has never made it to the human market? No need for it because dbol will do the job better? Well EQ is NOT liver toxic at sane doses where dbol is. You would think that that would be a selling point right there.

Also, I am thinking that there are just to many other things out there, ... dbol, test, var, primo, deca, adrol, winny, and they just really do not need it. But why do they feel horses need this so much when there are all those other choices out there? I am just curious what makes this compound so great for horses, but not great enough for people that it has never been made for the human market? Any thoughts?

Mavy

Maybe because there were too many AS on the market already so the millions spent on FDA approval would make it a poor investment?
Or maybe not as boldenone was developed in 1949, even before Dianabol.

ollowing the release of Parenabol, various clinical trials and testing of this compound was conducted in the late 1960s and early 1970s with the goal in mind to use it as a lean mass promoting and preserving anabolic steroid in order to treat individuals suffering from any condition in which wasting and weight loss were symptoms, as well as an osteoporosis treatment. Parenabol saw very little application or use following its release, and towards the end of the 1970s, it was removed from the market and discontinued.
Squibb would then pick up the patents for this anabolic steroid and re-release Boldenone under the name Equipoise as a veterinary anabolic steroid meant primarily for application in horses but is also intended for use in other animals.
Equipoise | Steroidal.com
IMO it was more expensive and not as powerful as testosterone so why bother?
Being different than test it wouldn't be used in TRT (the big $ market) thus left only to be used in rare wasting diseases, a much smaller market. AIDS wasn't there yet.

Some conspiracy theories say that Equipoise has a special magic on human health thus intentionally left out to keep MDs and big pharma profiting from nonending ailments.
BS IMO.
Interestingly enough boldenone is actually changing my life as a mild TRT, yet not as suppressive as testosterone.
I use it to recover from hypogonadism along with arthritis, chronic inflammation and treatment resistant anemia.