Why the AMES test does not say DNP is safe

[bigrand]

ive done it 5 times, weight stays of, about 7 lbs in 10 days.
I was a really fat ass after highschool with a lot to loose, so ive run it when ive gotten to points where fat loss was becoming stagnant.
ive done long 200mg and short 400mg cycles and a 600mg cycle (with allergic reaction that ive been ready for ever since).
Im at a point where ive got a good cardio regemin and not nearly the amount of fat to loose, so im staying away for now, unless i want get stagnant. Remember, the fatter, the higher set the bodys equilibrium for fat storage....harder to control weight.

I have done years of research on this (mostly through biochem classes and med shit) and i now just try to teach what ive personally learned. It works and can be relativly safe, but do your homework first, its serious shit.

 

[krishna]

I was just curious. I have no intention of ever touching that poison. I got up to 16-17% bf after my last cycle and am now down to 9% with nothing but diet and cardio. Haven't even touched a fat burner. If I ever do use anything for fat, it will never be DNP.

 

[bigrand]

I feel ya, its not for everyone. Im majoring in Bio, premed, so i learn about this shit all the time and feel confident enough to use it without hurting myself, thats why i do it.

 

[hawaii50]

These are all good points. But have you ever heard about your bodies natural PH level determining whether you will ever get cancer or not? There was a HUGE study about it a few years back... it read something like: If your body is naturally alkaline or acidic, you'll never get cancer.. but if you're natural ph level is base.. you can get it.

I personally believe that the FDA and other groups have covered that info up. I think in the same article it mentions that it is possible to alter your Ph level naturally.. without taking those nasty cancer drugs

has anyone else heard of this? I'll try to find that article... jeez where did i put that?

 

[krishna]

These are all good points. But have you ever heard about your bodies natural PH level determining whether you will ever get cancer or not? There was a HUGE study about it a few years back... it read something like: If your body is naturally alkaline or acidic, you'll never get cancer.. but if you're natural ph level is base.. you can get it.

I personally believe that the FDA and other groups have covered that info up. I think in the same article it mentions that it is possible to alter your Ph level naturally.. without taking those nasty cancer drugs

has anyone else heard of this? I'll try to find that article... jeez where did i put that?

Cancer has to do with genes that regulate cell division. Mutations in certain genes affect the division process as it is not regulated properly.

 

[hawaii50]

Cancer has to do with genes that regulate cell division. Mutations in certain genes affect the division process as it is not regulated properly.

yes, they mentioned that in there somewhere to.

 

[bigrand]

alkaline is the same as basic.
%50 of cancers have a mutated p53 gene responsible for apoptosis. Mutations to this gene rendering it null and unexpressed lead to unregulated cell growth and loss of contact inhibition. There are other genes responsible for controling apoptosis (cant remember off the top of my head), but there are other mutations involved. Changes in pH do have an effect, ie with acid reflux inducing esophageal cancer. Highly acidid environments can lead to increased incidence of cancer.

Cancer drugs arent meant to alter pH. Most anti-neoplastic agents are meant to break DNA strands and kill malignant cells, IE Cisplatin (PtCl2(NH4)2) is an intercalating agent which slides inbetween DNA and breaks it......that shit sucks, id rather go with gene reactivation if applicable.

 

[juiceddreadlocks]

alkaline is the same as basic.
%50 of cancers have a mutated p53 gene responsible for apoptosis. Mutations to this gene rendering it null and unexpressed lead to unregulated cell growth and loss of contact inhibition. There are other genes responsible for controling apoptosis (cant remember off the top of my head), but there are other mutations involved. Changes in pH do have an effect, ie with acid reflux inducing esophageal cancer. Highly acidid environments can lead to increased incidence of cancer.

Cancer drugs arent meant to alter pH. Most anti-neoplastic agents are meant to break DNA strands and kill malignant cells, IE Cisplatin (PtCl2(NH4)2) is an intercalating agent which slides inbetween DNA and breaks it......that shit sucks, id rather go with gene reactivation if applicable.

do you know anything about the kip and cif (I think it's cif) regions of the p53 gene which are responsible for I believe sequentially phosphorylating and turning on the active region of the protein?

wow, that was a clusterfuck of a sentence.

 

[cougar8]

Something to also note is cancer is a very additive disease. THrough the course of your lifetime, you accrue many mutations in your somatic cells. Most of these will apoptose or die off. Some will not. It takes a certain "critical mass" of mutations for cells to become carcinogenic. In many cases, this is between 5-7 mutations. This is termed the "multi-hit hypothesis" and is generally accepted in scientific circles.

Great post! I work in a cancer lab and have found many of these hypotheses to be true. However, though mutant cells tend to go through apoptosis until a healthy mass starts, we must not assume that it takes a long time for cancer to form. Cancer has and will develop quickly in some cases. So extreme caution should be taken when administering DNP. As it was mentioned earlier, DNP changes the proton gradient in mitochondria dramatically causing many changes in the cell biochemically and physiologically. Anyway, just my 2 cents. Good Post Though!!!

 

[bigrand]

Those regions you speak of i believe are in the promotor region, responsible for begining translation of the gene, mutations in this area will change the AA sequence and the promotor will loose function=no active gene function.
Ill check, i havent gone into specific sections of the gene, only AAs around the C terminus to make a primer used turn on unactive mutant p53 (did some reading on the subject).

With DNP, the actuall result of DNP by itself is the change in permiability of the mito membrane, no electrical gradiant can be established because H+ leaks out. The problem DNP causes is secondary, free radical release from WAT, this is what could lead to a mutation, not DNP itself.

Yep, the theory is about 7 mutations to become malignant.
Some cases only require a few mutations if they are in the right places (ie a null mutation in p53 stops apoptosis).