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Why I dont use winstrol...

Guvna

New member
Contrasting effects of testosterone and stanozolol on serum lipoprotein levels.

Thompson PD, Cullinane EM, Sady SP, Chenevert C, Saritelli AL, Sady MA, Herbert PN.

Department of Medicine, Miriam Hospital, Providence, RI 02906.

Oral anabolic steroids produce striking reductions in serum concentrations of high-density lipoprotein (HDL) cholesterol. We hypothesized that this effect related to their route of administration and was unrelated to their androgenic potency. We administered oral stanozolol (6 mg/d) or supraphysiological doses of intramuscular testosterone enanthate (200 mg/wk) to 11 male weight lifters for six weeks in a crossover design. Stanozolol reduced HDL-cholesterol and the HDL2 subfraction by 33% and 71%, respectively. In contrast, testosterone decreased HDL-cholesterol concentration by only 9% and the decrease was in the HDL3 subfraction. Apolipoprotein A-I level decreased 40% during stanozolol but only 8% during testosterone treatment. The low-density lipoprotein cholesterol concentration increased 29% with stanozolol and decreased 16% with testosterone treatment. Stanozolol, moreover, increased postheparin hepatic triglyceride lipase activity by 123%, whereas the maximum change during testosterone therapy (+25%) was not significant. Weight gain was similar with both drugs, but testosterone was more effective in suppressing gonadotropic hormones. We conclude that the undesirable lipoprotein effects of 17-alpha-alkylated steroids given orally are different from those of parenteral testosterone and that the latter may be preferable in many clinical situations.





That was only SIX mgs of stan a day.



There are plenty of other steroids available. I simply see no reason to use this one....or anadrol or halo for that matter.
 
Good post guvna! I've been seriously considering quitting orals for good. This is just another nail in the coffin. I think the only oral I'll use from now on is proviron.
 
this is likely due to several factors.
1. stanazolol does not convert to estrogen
2. stan is 17aa
3. stan is mixed agonist/antagonist of the PR

though 1 is a significant part of the equation.
 
I tried winny several years ago and I will never touch it again. It makes me shed hair like no other compound.
 
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injectable winny is much safer. only passes the liver once, on the way out. orals pass thru the liver on the way in, "first pass" and on the way out. also, much of the compund is lost in the first pass, making inj. mg for mg more effective.

that's the reason most don't reccomend oral only cycles. much harder on hepatic sys. don't let a fear of needles destroy your liver.

go with inj if you can. all alpha 17 compunds do this.
 
whitemahon said:
injectable winny is much safer. only passes the liver once, on the way out. orals pass thru the liver on the way in, "first pass" and on the way out. also, much of the compund is lost in the first pass, making inj. mg for mg more effective.

that's the reason most don't reccomend oral only cycles. much harder on hepatic sys. don't let a fear of needles destroy your liver.

go with inj if you can. all alpha 17 compunds do this.
The injectable is exactly the same for cholesterol. It took my good cholesterol
from 50 to 12 in 5 weeks. Ive said this in many many posts. It DESTROYS
your lipid profile. It takes months and months with fish oils niacin ect. to get it back up. Mine never has gotten back over 41. My liver values were only
slightly elevated though. I did 50mgsED. Never again. Too much cardiovascular risk on the lipid panel.
 
whitemahon said:
injectable winny is much safer. only passes the liver once, on the way out. orals pass thru the liver on the way in, "first pass" and on the way out. also, much of the compund is lost in the first pass, making inj. mg for mg more effective.

that's the reason most don't reccomend oral only cycles. much harder on hepatic sys. don't let a fear of needles destroy your liver.

go with inj if you can.

this is a myth. and long standing one.

17aa oral steroids have very low first pass metabolism (thats why they have high bioavailability)

17aa steroids pass through the liver over and over again (whether taken orally or injected)-

there is no health difference between a oral winstrol cycle and an injectable one. Injecting winstrol is just as hard on your liver.
 
good point about the lipid profile. the effect on your cholesterol will be the same, oral or inj. but as for liver values, inj is much safer.
 
tommy39 said:
The injectable is exactly the same for cholesterol. It took my good cholesterol
from 50 to 12 in 5 weeks. Ive said this in many many posts. It DESTROYS
your lipid profile. It takes months and months with fish oils niacin ect. to get it back up. Mine never has gotten back over 41. My liver values were only
slightly elevated though. I did 50mgsED. Never again. Too much cardiovascular risk on the lipid panel.

guessing it was a stanozolol only cycle.

might be hard to beleive, but stan only is way harsher on lipids than stan + test
 
Winny makes me shed like it's raining hair. Will never do it again.
 
DHT= lose hair, or have your prostate swell up ... both sh*tty sides you have even after your off

...get some good var
 
Mavafanculo said:
anavar KILLS HDL as bad or worse than winny. I get down into single digits after a few weeks on 70mg daily of var.


most orals will have negative impact on cholesterol, dbol and other aromatics have slightly less.
 
krishna said:
Good post guvna! I've been seriously considering quitting orals for good. This is just another nail in the coffin. I think the only oral I'll use from now on is proviron.


Thats what Im saying
 
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