I have used omnadren many times in the past, I start to feel it in a few days hot flashes, slightly agitated etc., I agree with all the others who say that noticeable gains in strength and size do not readily stat to occur before the end of week two or week three. I always use omns or sus at a starting dose of 500mgs and then 250mgs every three days thereafter. Test is test is test etc., that may be true but I believe that I react to omns and sus 250 better per milligram than any other test. In fact I get better results with a lower dose of omn or sus than I do with a single ester. Placebo or not, I don't care, but I know what I like the best.