Taken with carbs or WPH since the CTP (creatine trans protein) does the shuttling of Cr. The CTP is stimulated by insulin response which can be triggered by simple carbs or fast acting Hydrosylate. Don't worry about the acidic levels of whatever you're taking the Cr with. The acid in your stomach is stronger than anything you'll be drinking.
The most important thing is that you take it regularly and stay hydrated throughout the day.