I would have to say that time when I hit an 3 8balls of coc all night with two friends, went to school the next day, got two merpozine 50's from my dawg popped those, went to my boyz house, smoked up a joint with him, popped a special K and then at 6:00pm i tripped two hits of Acid.
Thats the worst I've ever done I think, If there is any worse I really don't remember it... But I'm no druggy, honest.