UG LrHGH

[Juice Authority]

http://boards.elitefitness.com/foru...d=266900&highlight=Medical+community+Nutropin

J Pediatr Endocrinol Metab. 2002 May;15 Suppl 2:715-22. Related Articles, Links


A long-acting human growth hormone (Nutropin Depot): efficacy and safety following two years of treatment in children with growth hormone deficiency.

Silverman BL, Blethen SL, Reiter EO, Attie KM, Neuwirth RB, Ford KM.

Department of Pediatrics, Northwestern University, Chicago, IL, USA. [email protected]

BACKGROUND: Nutropin Depots [somatropin (rDNA origin) for injectable suspension] is a long-acting form of human growth hormone (GH) to be administered by subcutaneous (s.c.) injection. The availability of this formulation offers the opportunity for greater convenience and compliance by decreasing the number of injections and frequency of administration required. OBJECTIVE: To determine the efficacy and safety of a long-acting formulation of GH administered in children with GH deficiency (GHD) once or twice monthly for 2 years. PATIENTS: Fifty-six previously untreated, prepubertal children with GHD received Nutropin Depot 1.5 mg/kg once monthly (1x/mo), or 0.75 mg/kg twice monthly (2x/mo) for 24 months. The mean pretreatment growth rate was 5.0 +/- 2.4 cm/yr. RESULTS: The 0-12 mo growth rate (mean +/- SD) was 8.3 +/- 1.5 cm/yr in the 1x/mo group and 8.2 +/- 2.0 cm/yr in the 2x/mo group. The 12-24 month growth rate was 7.2 +/- 1.5 cm/yr in the 1x/mo group and 6.9 +/- 1.5 cm/yr in the 2x/mo group. During the 24 months of treatment, height standard deviation score (SDS) increased by 1.0 +/- 0.5 SD in the two groups combined (p <0.0001). The corresponding advancement in bone age was 2.2 +/- 0.7 yr, resulting in a gain in Bayley-Pinneau predicted adult height (PAH) SDS of 0.6 +/- 0.9 SD in the 1x/mo group and 0.6 +/- 1.0 SD in the 2x/mo group. No serious adverse events attributable to the study drug were reported. Injection site reactions were common, but resolved without intervention. Pre-dose fasting and postprandial glucose and insulin levels, as well as hemoglobin A1c levels, were unchanged from baseline values. CONCLUSIONS: Treatment with Nutropin Depot is associated with catch-up growth and normal skeletal maturation and is a viable alternative to daily injections of GH in children with GHD.

Publication Types:
Clinical Trial
Multicenter Study

PMID: 12092685 [PubMed - indexed for MEDLINE]

 

[thx9000]

Statement from Nutropin Depot site (little cropped but gets the message across)


Estimates of relative bioavailability for a single dose of Nutropin Depot ranged from 33% to 38% when compared to a single dose of Nutropin AQ® [somatropin (rDNA origin) injection] in healthy adults, and from 48% to 55% when compared to chronically dosed Protropin® (somatrem for injection).

I'll take the daily injections over the bi-monthly or monthly.

Okay, I thought about this.

Nutropin is heat sensitive, and this UGL stuff supposedly isn't. So, I'm not sure we can apply this study to the UGL product. I say this because Nutropin will be wandering around or in depot in your 98C body for up to 28 days which can't be too good for the product's bioavailability.

 

[Kepeli]

Nutropin AQ is heat sensitive. Nutropin Depot shouldn't be if it is to be time-released over a 2-4 week period. This is just a guess, though. I will go look and see. I cant see them marketing a product that degrades too quickly in the body.

 

[georgie24]

more feedback!!!

 

[alltraps]

i want to try this GH badly, but need more feedback

 

[benevolent anarchist]

Last night before bed I started feeling a little ornery. When I woke up to go to the bathroom, you can imagine my shock and horror when I looked in the mirror and saw a green face staring back at me. I had become the Incredible Hulk.

Smartass comments aside, I realize you guys are hungry for feedback, but you are just going to have to wait if you want detailed results. Unlike AAS, the gains from rHGH come slowly and steadily. Also this product just came out and most people are only on their first month or so. I’m only on my second week. The general feedback from those who are using it is very good and I can tell you this. The stuff feels like good rHGH. Not trying to sound condescending, but if you think that sounds hokey and you don’t know what I mean, then I don’t think you’ve ever used good rHGH.

Stay tuned.

 

[georgie24]

good morning everyone

 

[benevolent anarchist]

good morning everyone

It certainly is.

 

[Miracle Man]

People, the issue of heat sensitivity is strictly in shipping and handling of the product. All Hgh is heat sensitive Even Serostim should not be exposed to heat. This is the main problem when dealing with street Hgh. Handling of the product during the spring / summer months kills the rDNA.

Think about it, you guys are being to analytical. There is no difference in body temperatures from Adults to Children. Nutropin Depot has a pediatric indication by the FDA. It works in kids, The shorter acting Nutropin AQ works better because it mimics closer to natural Hgh release in the body. All pediatric doses are given at night.

The UGL that released there version of long acting Hgh does not have to be refrigerated by their claims. I would like to see how their delivery system compares to Nutropin Depot? If I had to bet, it will not even shine the shoes of Nutropin Depot. But to be fair, Supra does make a good product.

The bottom line is Nutropin Depot delivers the goods in a BIG way. The adult clinical trials with the depot are being completed as we speak. But take the indication with a grain of salt. They are not studying this fine product for BB or athletic purposes.

All Hgh should never be exposed to heat. That is already a given.

 

[georgie24]

how much would real nutropin run?