im not all in the chimical breakdown of the tren. i can only speak as the lab rat. i never got itchy nips or any signs of gyno even on very high levels of tren with no anti-e's. i even took high doses of tren and after stopping it for only 2 weeks, i was tested for steroids under suspision in the navy and it came back negative. that was from UCLA. i thought i was fucked. but after only 2 weeks off i get tested negative, i even saw the paperwork that came back from UCLA that showed the results. weird, i thought AAS stays in your body for quite some time. the only problem i had was when i went in for a physical i was on tren only and they said my ketones and protien in my urine was high. i told them i took a lot of protien shakes and they said to lay off for a couple days and come back to retest. i waited 5 days, stayed off the tren and the test came back way normal. the tren goes away from the body rather quickly. hope this helps.