Trenbolone: PR agonization or ER agonization?

[Andy13]

I believe that test is test, right? Now that is settled, how do you believe that sus has four receptor sites, and
how so?

I would like to be informed about this. Also, what is the difference between a anabolic receptor/androgenic receptor? I think that they are one and the same.

Please enlignten me about this difference of research
opinions.

um... who said there are 4 AR's? There is one (that we know of)

 

[bigrand]

Sust dont act on 4 receptors, sust is a combo of 4 test esters of various lengths. This allows test to be released at different times.
There is no anabolic receptor, just an androgen receptor. there are no "anabolics" in the blood like there are androgens, estrogens, progestins and other hormones that need a recepter to attatch to. the term anabolic is in reference to a substance that increases anabolism. Its an act not an actuall substance. I guess...

 

[justwannagetsum]

It must be nice to have someone raise you with whom you can have intellegant conversations

You've got to appreciate the irony of this statement and the spelling of "intellegant"


Panerai, where in the hell do ou find these studies????im impressed. The only thing I question. Maybe the PR receptor in the bovine uterus is different then in male humans? Otherwise I think tren would produce instant gyno. Just a guess. the study was following recpetors in the bovine uterus. This does prove that there is however, progesterone binding of tren to some degree anyways. i have been looking for proof of this, thanks.


BigAndy, I think the whole entire trenbolone molecule is planar. except to a small degree the 4th , 5membered ring. There are double bonds on the first 3 rings. I wouldnt know the physiological consequence of this with reguard to ER binding however.....

 

[macrophage69alpha]

um... who said there are 4 AR's? There is one (that we know of)

it is likely that there is more than one... there are at least 2 ER receptors..

 

[Frackal]

Nitotech acts on all the AR receptors.

[size=-111] That's my intelligent contribution this time...hehe[/size]

 

[jboldman]

I have read every study on medline with trenbolone mentioned and that study was the only one that mentions trenbolone and its affinity to the bpr. My problem here I guess is that we are jumping to the conclusion that just because tren binds slightly better than P in a cow's uterus that it also binds in a similar way in humans at other sites in the body. This really seems like a stretch. Help me out here.

Great. TS is back <sarcasm> j/k

I should have bee more precise in my wording....LOL
I swear Andy is like a coiled cobra waiting to spring......
But no problem, I like being kept on my toes.

Befor I answer Andy's post, Andy13 please look at Panerai's
study. Your little ER theory is now SHOT.

(I had been trying to locate the same study Panerai.)

I should have said that Tren has a lower affinity to
the PR receptors than Deca does.

Same goes with Test and EQ in relation to the ER
receptor.

This would explain why some people get gyno off Deca
while on Tren its pretty rare.

Godspeed

 

[eagle64]

Interesting concept, dual-agonism.
Then, how on earth do we measure the probablility
of tren agonizing the ER or the PR????

I guess we are talking here about ER and PR CLINICALLY evident action.

In this regards, if Tren were both a ER and PR agonist we should expect a huge amount og gyno from tren alone use, which is not what I have heard and seen so far.

On top of that, if tren was also a ER agonist there would be no need to have it always with estrogen in cattle implants, when an clinically evident estrogen action is required.

 

[Andy13]

It must be nice to have someone raise you with whom you can have intellegant conversations

You've got to appreciate the irony of this statement and the spelling of "intellegant"



.....

(tee-hee!) I can't spell worth a shit.. I'm always asking my girlfriend how to spell the most rediculous words...

 

[Andy13]

it is likely that there is more than one... there are at least 2 ER receptors..

I know there are at least two DNA binding domains on the ER.. There are studies with mutant ERs where the DNA binding domain has been deleted... It still had biological activity.

 

[Andy13]

Re: bump

Damn there are some nice old threads in the search engine.

I had forgot about some of these threads you've dug up!