Some usefull information you may want to read...
Tren- Fat burning and "fina cough" both from prostaglandin metabolization
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by Pheedno
-It's been widely disussed of Trens fat burning properties through rises in IGF and Prostaglandins. While IGF is a fairly well known substance in the bodybuilding world today, prostaglandins are fairly unknown in terms of formation and roles in the body.
So below, a brief dicription of prostoglandins and their role in fat burning, "fina cough", and why a person going through Tren administration can experience it's fat burning effects without the dreaded "Cough"
The term prostaglandin comes from the word-Prostate. The first prostoglandins were first dicovered in semen about the mid 1930's and it was thought that prostaglandins were made from the prostate. Since this time, it has been dicovered that most prostaglandins are not even constructed in the prostate.
Prostaglandins are made by two different pathways(Cyclooxygenase and Lipoxygenase), and considering prostaglandins are a group of about 20 lipid cells, they have contrary function; responsible for stimulating as well as alleviating inflammation(Inflammation stimulation is the rapid metabolism of them expelled through the bronchials), regulate blood flow to particular organs, control ion transport across membranes, modulate synaptic transmission, induce sleep, mediate lipid release, and regulate metabolism is various tissue.
Prostaglandins are synthesized from arachidonate(Lipoxygenase which catalyze the dioxygenation of polyunsaturated fatty acids) in the cell membrane by the action of phospholipase A2. Cyclooxygenase and lipoxygenase pathways, compete with one another to form prostaglandins(as well as thromboxane or leukotriene-leukotriene being a bronchial stimulator),
In the cyclooxygenase pathway, the prostaglandins D, E and F plus thromboxane and prostacyclin are made. Thromboxanes are made in platelets and cause constriction of vascular smooth muscle and platelet aggregation
Leukotrienes are made in leukocytes and macrophages via the lipoxygenase pathway. They are potent constrictors of the bronchial airways. They are also important in inflammation and hypersensitivity reactions as they increase vascular permeability.
Being that prostaglandins from either pathway, are still fatty acids of a group, they mediate lipid release and controll tissue metabolization, so fat burning is a luxerry of either pathway of formation. It's the pathway from which they are constructed that dictates "fina cough". As prostaglandins made from the Cyclooxygenase pathway dictate muscle constriction and platlet aggregation, and the Lipoxygenase pathway dictates bronchial constriction(the main form of expulsion)
Refs:
Cackatoo Press
Columbia Encyclopedia 6th Edition
Science Daily Magazine
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by Huckleberry FINNaplex
Hey fella's. I dug up a nice little scientific study on some of the activities of trenbolone.
Brief summary: Anabolic to androgenic ratio of 2/3 (meaning it is doubly as anabolic as test and 3 times as androgenic) It also shuts down the endocrine system much harder (likely due to that 3 time androgenic capacity). Just thought I'd share this little scientific factoid with my brotha's who love trenbolone.
Pharmacological and endocrinological studies on anabolic agents.
Neumann F.
When used in connection with animal production the term "anabolic agents" covers a wide range. Ther steroidal male and female sex hormones are included in this list, as are the nonsteroidal estrogens. For the clinician and for the endocrinologist, anabolics are only steroids chemically related to testosterone and 19-nortestosterone. Estrogens, though possessing anabolic properties, too, do not belong to this class. This paper will deal with anabolic agents in in the stricter sense of which mainly trenbolone acetate combined with hexestrol has been recommended for bull and heifer fattening. To consider possible consumer injury from ingestion of meat from anabolic agent treated animals, it is necessary to know the pharmacological properties of the agents, the doses producing certain effects or might produce, and the levels of residues in the meat. Trenbolone acetate will be compared with the following anabolic agents: methenolone acetate, methandrostenolone, nandrone, androstanazole, and 19-nortestosterone.
The activity spectrum of trenbolone acetate is similar to that of 19-nortestosterone or those anabolics that are derived from 19-nortestosterone. The compound has about three times stronger androgenic effect than testosterone propionate. Its index of dissociation between anabolic/androgenic activity is 2--3. This index is 3--10 for the other anabolic agents. As regards the virilizing potency, trenbolone acetate is also on the top of the list. It seems that androgenicity and degree of virilization run paralle. The antigonadotropic activity (inhibition of ovulation and testicular growth) of trenbolone acetate exceeds that of testosterone propionate by the factor 3. The compound is not estrogenic and seemingly not or only weakly progestationally active. In principle, the androgenic activity (symptoms of virilization) as well as the antigonadotropic effect (disturbances of the menstrual cycle in women, inhibition of spermiogenesis in men) of trenbolone acetate might be noted. This risk, however, can be excluded by mere calculation.
In rats, 0.1 mg/kg trenbolone acetate have an antigonadotropic effect. This corresponds to a daily dose of 5--7 mg in humans. By the same extrapolation, a daily human dose of 100 mg can be calculated for androgenic activity. Such factors of conversion are, of course, not precise because rats are much less sensitive to androgens and anabolics than humans. Thus, testosterone propionate is active only in daily doses of 10--20 mg. If in humans trenbolone acetate also has three times the activity of testosterone propionate, effects in man had to be counted with not less than a daily intake of 3--5 mg trenbolone acetate. The dose which is recommended for livestock fattening is 300 mg. IT can, therefore, be excluded almost with certainty that the meat would contain such large amounts of hormone residues.
Q: Huck, thanks for the good post. Given the information, what would be your further remarks regarding trenbolone as a bodybuilding AS?
A: It's the strongest androgen receptor binder on the planet. It has ferocious anti-glucclocorticoid actions and I have a theory that it is a potent activator of endogenous Prostaglandins (particularly F2a) which gives it some terrific lipid burning potential.
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All You Need to Know About Fina
I wrote and posted this on Elite a few months back, and I figure since it is my only worthwhile post I have ever made, I should share it with you fellas.
As you can tell by reading the boards every day, Fina is obviously one of the most popular "supplements" in the bodybuilding community today, and for all the right reasons.
I am writing this post due to the obscene amount of private messages I have received recently and the even larger number of posts on the subject of Fina. I am sure many of you have read Huck's AWESOME thread entitled "The Power Of Trenbolone." That thread was very scientific to say the least, so I am taking it upon myself to write out a condensed version of that thread in laymen's terms. I will attempt to cover every aspect that has been talked about recently...if I miss something than people like Huck, Fonz, Zyg, and (even though I despise him greatly) TxShortPenis to chime in, along with anyone else who has questions or other various points. Here goes....
Fina is considered by many, including myself obviously, to be
The Gear of the Gods. Those who have not had the pleasure of experiencing the joy that is fina seem to be in the minority these days. Fina is cheap, safe, and extremely effective.
What is it?
Fina (who's scientific name is Trenbolone ) is a derivative of the chemical nandrolone. Tren does not convert to estrogen, so supplementing with anastrozole, lestrozole, or any of those popular compounds will do no good combating the gyno that may be caused by using Tren, but we will get to that later.
To quote Huck, " [Tren] is the strongest androgen receptor binder on the planet. " This in itself is amazing considering it is a derivative of a compound that is far less androgenic. If you read Huck's post (now in the Best of Elite Fitness forum) you will see a scientific study that shows how Tren is three times as anabolic as testosterone, while being doubly as anabolic.
Tren is commonly used in cattle. Farmers inject Tren into their cows in the months leading up to their slaughter to rapidly increase lean weight gain, which makes for some yummy steaks.
Where can I get it?
Capitalizing on the fina frenzy, sources began producing their own home-made trenbolone and put them on the market. Ttokkyo was the first actual company to produce trenbolone for human use. Needless to say, the prices were and still can be outrageous.
What are we to do then? Well make your own you lazy bastard! Fina pellets can be purchased legally from any vet store. Look for either their Finaplix-H or Component T-H, which IS fina, just more of it.
Unless you have the brain capacity of llama (Mustang_18 ) you will immediately realize that using an implant gun to shoot these fina pellets into your body is a painful and unnecessary experience. There are in fact a few safer and less excruciating method to experience the power that is fina:
Orally: It seems that some have attempted to place the fina pellets under their toungue until dissolved. Aside from being about as tasty as TxShortpenis' loose anus, this method will yield minimal results, if any at all.
DMSO Method: Basically, this consists of crushing up the pellets and adding them to a topical delivery system. You then rub the composite onto your body in various places (behind the knees, for example). This will yield better results than the previous method, however the results may not be spectacular, and you will smell like trenbolone 24/7, which will not make you that popular with the ladies.
Injections: In my opinion, and the opinion of many others, this is the ONLY way to use fina. I know you are probably asking, "Hey Almighty you ignorant piece of shit! How the fuck would you go about injecting something in pellet form?" Listen here, shitheads, you can purchase a kit to make the transformation from pellet form to liquid form.
The main concern when this method is brought up is,
"Hey, Almighty. Im no chemist you insensitive prick. What am I to do?" First of all, you got a real bad attitude son. Second, I am the farthest thing from a chemist. Making fina is easier than baking a cake, and no I am not joking. All kits come with step-by-step instructions on how to convert your fina. The entire process can take anywhere between 2 hours to 12 hours. The majority of this time is waiting for the pellets to dissolve in the oil that is supplied via the kit that you purchase. If you want to look at a great site that has pictures of this process, simply go to
http://www.elitefitness.com/members/finaplix/
The kits give out a 75mg/ml concentration of the golden goodness. Of course, you can alter this by changing the amount of solution you use, but 75mg is typically the standard dose.
One more small thing...for best results, due to its short half-life, fina must be injected at least every other day (EOD). For OPTIMAL results, every day (ED) injections are encouraged. This is what intimidates many of those who are interested in using fina. Take it from me and the countless numbers of those who have used fina...the ED/EOD injections are not a problem at all. You get used to them in a short amount of time, and do not want to stop doing them once you see the phenomenal results. I know that your asses are probably getting sore thinking about all of those injections, but fear not. Fina is great for site injections. I inject into my bis, tris, delts, and pecs with no fuss, no muss.
How should I use Fina?
As I stated above, the standard dose of fina is usually 75mg. While in 95% of people this dose results in little sides and great results, many people opt for 37.5mg (1/2 ml) every day.
Fina kicks in very rapidly (many notice results within the first week) so the standard 10 week cycle is not necessary. Fina is a great addition to a 10-12 week cycle consisting of test, eq, primo, etc. I advise adding fina at the end of the cycle, the last 5-6 weeks perhaps. Be sure to extend the fina past the rest of the cycle if you are using compounds that take longer to clear your system (e.g. sustanon / omnadren, eq, deca). This way, you can start your post-cycle therapy directly following your last dose of fina.
If all else fails, a 6 week fina cycle never lets anyone down. Combine fina with other fast acting compounds such as test prop or winny and you have yourself one helluva cycle with a minimum cost. Using myself as an example, in 6 weeks of using fina @ 75mg/ed and winny @ 50mg/ed I gained 22 pounds and lost 2% body fat. Not bad for 6 weeks, huh?
Should I use Fina to Bulk or Cut?
Due to the fact that God himself was on fina when he created the world in 7 days, fina is great for either. Fina is extremely anti-catabolic which makes it the drug of choice for cutting. People report an actual increase in weight while their body fat drops. Fina is renown for its ability to transform your physique.
For bulking, well just add some test, dbol, or any of your other favorite bulking supplements and watch the weight and strength pile on while experiencing little or no increase in body fat.
Is Fina Dangerous?
In my opinion, the horror stories you hear about fina are extremely overdone. Fonz ran fina for more than 20 weeks....20 fucking weeks and reported no problems whatsoever. All you have to do is to do your homework, take the necessary precautions for the liver and kidneys (ALA and 2 gallons of water every day, respectively) and chances are you will be good to go, as long as the dose is reasonable.
By the way, the sides of fina are pretty much the same as all other steroids, such as acne, hair loss, etc. Fina does seem to cause an increase in aggression in some people. Of course, as long as you have at least a minimal amount of will power, this aggression can be contained and expelled only in the gym during a grueling workout.
Now, what about gyno? Ask anyone around and you will see that, although it can happen, gyno from fina is quite rare. Arimidex, etc will not prevent gyno from fina, so if you are truly paranoid, simply supplement with 50mg of winny EOD.
If you are like me, you may get a slight case of gyno after the cycle has ended. Many seem to think that this may be prolactin induced. This gyno can, 99% of the time, be easily cured by supplementing with 1 gram of vitex (chaste berry) every day until the symptoms disappear. In my case, it took only a few weeks.
Is fina adequate for someone doing their first cycle? Yes and no. I feel that if you have done your homework, fina will work quite well with a lack of sides as long as you are smart and keep an eye on what you are doing. Keep in mind, however, that fina is very strong and, like all other steroids, may not be for everyone. I know that the frequency of injections can deter many from using fina in their first cycle. If you can go along with it, however, I assure you that the results will be like nothing you have ever experienced before.
That's pretty much it gentlemen. It took me only about an hour to write this, so I may have left some things out. As I said above, feel free to add or subtract anything you see fit. Happy Growing.
as posted and written by The Almighty
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