Tren - gear of the gods

[TxLonghorn]

I will have to take out a loan and hire prostitutes to perform obscene amounts of felatio on Zyg and TxLonghorn for getting me started on Fina.

And I will have to just accept this offer, lol.

 

[Zyglamail]

zyg, if igf-1 is a hormone & will not bind to the ER, then how does it ( supposedly ) cause gyno ? help, because i love tren !

To be honest I am as of yet not 100% sure of the exact cause/effect but I have seen many abstracts as well as other reference material point to IGF-1 levels causing gyno, among many other problems. Here is a quote that gives a small explanation:

Dr. Samuel Epstein, professor of occupational and environmental medicine at the University of Illinois School of Public Health and chair of Cancer Prevention Coalition, Inc., reports that IGF-1, which causes cells to divide, induces malignant transformation of normal breast epithelial cells, and is a growth factor for human breast cancer and colon cancer. Yet rBGH was never adequately tested before the Food and Drug Administration allowed it on the market. A standard test of new biochemically produced products and animal drugs requires twenty four months of testing with several hundred rats. But rBGH was tested for only 90 days on 30 rats. This short term rat study was submitted to the FDA but never published. The FDA had refused to allow anyone outside that agency to review the raw data from this truncated study,
saying it would “irreparably harm” Monsanto.

A simple search on goole for Gynecomastia igf-1 will give you days of reading if you are so inclined.

Hormones are fall into one of 4 basic groups

Peptides and proteins
Steroids
Amino acid derivatives
Fatty acid derivatives(ie Eicosanoids)

IGF-1 falls into the peptides and protiens catagory. Here is a bit more info

Insulin-like Growth Factor 1

This protein of 70 amino acids was once called somatomedin because it, not growth hormone, is the immediate stimulus for
growth of the body.

Growth hormone released from the anterior lobe of the pituitary
binds to receptors on the surface of liver cells.
This stimulates the synthesis and release of IGF-1 from them.

Many cells have receptors for IGF-1, especially cells in the bone marrow in the cartilaginous growing regions of the long bones.
Binding of IGF-1 to cells with receptors for it stimulates them to move from G1 of the cell cycle to S phase and on to mitosis.
These are not the same as the Igf-2 receptors whose genes are imprinted.

The levels of IGF-1 in the blood are highest during the years of puberty which is, of course, a time of rapid growth.
Occasionally children are found that have stunted growth because they have inherited mutant genes for the growth hormone (GH) receptor. Recombinant human IGF-1 has been successfully used to treat them.

There are literally hundreds of thousands of good info pages on the net for you or anyone else to read, so if you love tren so much, your more than welcome to dive into the web and read to your hearts content.

Honestly I think gyno from tren is more a result of increased igf-1 that its affinity to the PR receptor. IGF-1 increases are also one of the things that make this drug so powerfull. At the same time however people can easily make decent gains on as little as 75mg/eod and gyno at that dose is unheard of....at least by me.

 

[Zyglamail]

shameless bump

 

[rocketrman]

thanks zyg for that resoponse. i appreciate the time you take to share this kind of great info. karma comming !

you are right 75 eod ( i done 150eod & 75 ed & got excellant results w/o symptoms of gyno, so far ... ) will yeid good results.

 

[Suspension]

Tren fucking rules.

You can eat as much as you want (clean foods) and STILL burn fat/gain muscle. It truly is a miracle drug, and will be part of almost every stack i do!