Trans dermal info for everyone

[lord_regulator]

Okay let me get one thing straight of the bat I am not afraid of the needle so no flames saying lord just stick it hehe.

Okay this is just some info for everybody. I take it everyone has heard of trans dermal application if you haven’t well you should have transdermal is mostly used for fina but it can be used for almost any steroid with a molecular weight of around 400 and under.

Personally I would never use the DMSO product for trans dermal because you will stink like garlic

I would use Phlojel its by far the best go to http://www.phlojel.com to learn more you can get phlojel for about 24.00 at any local pharmacy world wide its totally legal.

The benefit of using phlojel is the obvious if you are scared of needles & it is great for site reduction in fat or gain in muscle because it hits the area were it is first applied to, just like site injection. The downside is you will lose about 20 percent of the product so for 100mg of test you would only get 80mg

Here are the Molecular weights of some common steroids that could be used trans dermal
EQUIPOISE=Substance: boldenone undecylenate= Molecular Weight=286.4
TESTOSTERONE ACETATE=Molecular Weight=330.5
TESTOSTERONE ENANTHATE= Molecular Weight= 392.5
PRIMOBOLAN DEPOT= Substance: methenolone enanthate= Molecular Weight=302.4
WINSTROL DEPOT = Substance: stanozolol= Molecular Weight= 328.5
Finaplix= Substance: TRENBOLONE ACETATE= Molecular Weight= 312.4

If you have any questions you can E-mail me or PM me For other Molecular weights

On a personal note to Newbies one fuucking hell of a cutting stack to totally rip you abs
About a quarter size of phlojel on skin and crushed Winstrol, Fina, Yohimbie HCL
You will get supper shredded

 

[kingcreed2000]

Dosage?

What would the dosage be for the yohimbe, winny, and fina combo for cutting? How good are results without the fina? Read the post about using yohimbine topically but will yohimbe work as well?

 

[winstrol69]

Phlojel sucks. Ask swolcat.

 

[BSmooth]

I have used DMSO twice now for extended periods of time. Never have I had bad breath or stunk like garlic from it. Everyone is different in this aspect. By the way both times I have used rosemary scented DMSO cream.

 

[Big Moose]

I have been using phlogel for the last three weeks and am pretty happy with the results. However, I will start injecting as soon as I finish converting.

 

[hairygoose]

DMSO???

Hey so are you saying that if I purchase finaplix pellots with the gel id still get results by just crushing them up and applying it to my abs? I already have the yohimbine HCL, wqould the fina work as well?

 

[lord_regulator]

Yes for cutting just sprinkle about 5mligrams yohimbie on the phlojell around your abbs wrap with suround wrap. I really get deep cuts in abbs with EQ for some reason

 

[lord_regulator]

Another thing though if you use DMSO usually a molecular weight will not pass through of any higher than 325 were with phlojel you could go up to a molecular weight of 450 max that would be pushing it but say if you were to use primo most people would do 300 mg injection about once a week i would do it dmso
Monday 150mg Wednesday 200mg Saturday 150mg
Rotating abb spots
If you want a good sight for finiding the molecular weight of every drug go to here http://www.steraloids.com/trivindx.html
The go to the chemical ingrediant name for example you could not look up Winstrol you would have to look up the active ingredient which is STANOZOLOL
And so on with other anabolics
Phlojel and transdermal is also great for like hives i get crazy ass alergys some times and get hives so i take some phlojel and crush up benadryl capsule and apply it right to the hive gone in about 1 hour

 

[Big Johnson]

ANYONE KNOW THE MOLECULAR WEIGHT OF PGF2a?

 

[macrophage69alpha]

PGF2A will pass through your skin without a carrier, though not as well as yohimbine which DOES NOT need a carrier.

Yohimbine HCL is readily absorbed through the skin.

peace
BTW- stanozolol is 17 aa and should, IMHO, NEVER be injected.

 

[aburgtank]

MORE INFO FOR EVERYONE, PLEASE

Hell ya I think I'll try that little stack, good post!



Oh yeah, the is my first post on the new board and I think the nw look fuckin rocks! Good speed now too but I may be posting at an off time!

 

[lord_regulator]

 

[cockdezl]

Transdermal is still only going to get at best 20-30% absorption. Esterified drugs can be used, since there are esterases present in the tissues, which will release the free drug.

Also, primobolan depot can be taken orally, since it is the 1-methyl group that confers protection from metabolism, not the ester.

 

[Montecristo]

Ok, you guys mentionned molecular weight as a determining factor here. What about base ie: Sustanon 250 can be based on oil or alcohol... Think you could use this with an oil based sustanon like the nile stuff...

 

[lord_regulator]

Yes i see we are finally geting some tru scientists on board here
I have always said that through education you will atain your greatest goals for any body who truly wants to learn the chemical make up of specific anabolics and drugs go to http://www.steraloids.com/trivindx.html
i have found it great for chemical formula,Molecular Weight,Melting Point,Rotation

 

[bigrand]

the cock speaks!
This is a great thread. With this info, one could cut the injections down and those that are needle shy could use AAS Trans. No prop hurting like a bitch. Keep the good info coming gure and cock.

 

[Phreaky]

Okay let's get this straight here....is it because of the ester or the parent compound that makes it orally available? Is this why Trenbolone acetate is purported to be orally active?

 

[kickboxer99]

Cockdezl---Why is it only effective for 20-30% absorbtion? Does anyone else have any idea what the absorbtion rate is?

 

[lord_regulator]

The real absobrtion rate for Trans Dermal is eighty percent not twenty to thirty percent

 

[cockdezl]

"The real absobrtion rate for Trans Dermal is eighty percent not twenty to thirty percent"

REGULATOR, if you can give me one study that shows a formulation which gives 80% recovery of an applied hormone, I would be a happy man. I'd have that shit made up and would be selling it right now. Look up the research...transdermals have a tough time fighting their way through the stratum corneum.

"Okay let's get this straight here....is it because of the ester or the parent compound that makes it orally available? Is this why Trenbolone acetate is purported to be orally active?"

The ester is what gives an INJECTABLE drug its half-life. It modifies the drug's potential to remain in it's vehicle (oil or water), or to exit the vehicle and enter the tissues/blood.

Chemical modification of the base drug is what gives the majority steroids protection from hepatic metabolism. Most are 17-alpha alkylated, some are 1-alkylated. The exception is Andriol (testosterone undecanoate). This drug is orally active, due to its highly lipophilic ester, which partitions itself in chylomicrons and is taken up by the lymphatic system. Unfortunately, it tends to remain in the chylomicrons, thus giving very low release and effects.

 

[MAXOUT]

Can someone post a structure of Trenbolone acetate?

 

[lord_regulator]

Trenbolone Acetate structure
E3171 4,9,11-ESTRATRIEN-17-OL-3-ONE ACETATE
Formula C18 H24 O3

Molecular Weight 312.4 Rotation +36.8° MeOH
Melting Point 96-97°C

 

[Anabolix]

I'm willing to see what happens if i use SUST 250 transdermal. Do you guys think that it can go through?

LORD_REGULATOR - YOU'VE GOT MAIL.

 

[MAXOUT]

the ester is what gives an INJECTABLE drug its half-life. It modifies the drug's potential to remain in it's vehicle (oil or water), or to exit the vehicle and enter the tissues/blood

on a side a note: the longer the side chain on the 17a the lower the androgenic activity

it's not the 1-beta alkylation that protects it, but the double bond that is transferred from the 4 position to the 1 position that allows it to survive first pass in the liver. instead of bypassing the enzyme that deactivates AS like 17-aa steroid primo works on this enzyme to reverse the reaction equilibrium to favor the active state instead of the inactive state. this doesn't do jack though.

no flame intended but what did you reference in order you come up with that MOA.

As a general rule, the metabolism of steroid hormones involves sequential additions of oxygen or hydrogen atoms, followed by conjugation to form water-soluble derivatives. Reduction of the 4,5 double bond occurs at both hepatic and extrahepatic sites, yielding inactive compounds. Subsequent reduction of the 3-ketone substituent to the 3-hydroxyl derivative, occuring only in the liver. Most of these A ring-reduced steroids are conjugated through the 3-hydroxyl group with sulfate or glucuronide by enzymatic reactions that take place in the liver and, to a lesser extent, in the kidney. The resultant sulfate esters and glucuronides form water-soluble derivatives and are the predominant forms excreted in the urine. Neither biliary nor fecal excretion is of quantitative importance in human beings.

 

[BSmooth]

I would like to see ANY facts on transdermals absorbtion rate.. Whether it is 20, 30 or 80 percent, everything you guys has stated is hypothetic. Personally, I would rate transdermal at near 80%.

 

[MAXOUT]

Interesting structure as compared to test........

"these compounds resist metabolic deactivation by profoundly shifting what is known as the “17-keto redox potential” towards the formation of active 17beta-hydroxyl steroids.[ii],[iii] What does this mean? It means that when you take 1-AD, the liver serves primarily to activate the compound, rather than break it down and excrete it as it does with other prohormones and testosterone. It means that 1-AD is “orally active,” yet it does not impart the liver toxicity that 17alpha-alkylation does."

 

[cockdezl]

"I would like to see ANY facts on transdermals absorbtion rate.. Whether it is 20, 30 or 80 percent, everything you guys has stated is hypothetic. Personally, I would rate transdermal at near 80%."

Here you go, BSMOOTH:

J Clin Endocrinol Metab 2000 Dec;85(12):4500-10

"Long-term pharmacokinetics of transdermal testosterone gel in hypogonadal men."

Swerdloff RS, Wang C, Cunningham G, Dobs A, Iranmanesh A, Matsumoto AM, Snyder PJ, Weber T, Longstreth J, Berman N.

Divisions of Endocrinology, Departments of Medicine/Pediatrics, Harbor-University of California-Los Angeles Medical Center, Torrance, California 90509, USA.

Transdermal delivery of testosterone (T) represents an effective alternative to injectable androgens. Transdermal T patches normalize serum T levels and reverse the symptoms of androgen deficiency in hypogonadal men. However, the acceptance of the closed system T patches has been limited by skin irritation and/or lack of adherence. T gels have been proposed as delivery modes that minimize these problems. In this study we examined the pharmacokinetic profiles after 1, 30, 90, and 180 days of daily application of 2 doses of T gel (50 and 100 mg T in 5 and 10 g gel, delivering 5 and 10 mg T/day, respectively) and a permeation-enhanced T patch (2 patches delivering 5 mg T/day) in 227 hypogonadal men. This new 1% hydroalcoholic T gel formulation when applied to the upper arms, shoulders, and abdomen dried within a few minutes, and about 9-14% of the T applied was bioavailable. After 90 days of T gel treatment, the dose was titrated up (50 mg to 75 mg) or down (100 mg to 75 mg) if the preapplication serum T levels were outside the normal adult male range. Serum T rose rapidly into the normal adult male range on day 1 with the first T gel or patch application. Our previous study showed that steady state T levels were achieved 48-72 h after first application of the gel. The pharmacokinetic parameters for serum total and free T were very similar on days 30, 90, and 180 in all treatment groups. After repeated daily application of the T formulations for 180 days, the average serum T level over the 24-h sampling period (C(avg)) was highest in the 100 mg T gel group (1.4- and 1.9-fold higher than the C(avg) in the 50 mg T gel and T patch groups, respectively). Mean serum steady state T levels remained stable over the 180 days of T gel application. Upward dose adjustment from T gel 50 to 75 mg/day did not significantly increase the C(avg), whereas downward dose adjustment from 100 to 75 mg/day reduced serum T levels to the normal range for most patients. Serum free T levels paralleled those of serum total T, and the percent free T was not changed with transdermal T preparations. The serum dihydrotestosterone C(avg) rose 1.3-fold above baseline after T patch application, but was more significantly increased by 3.6- and 4.6-fold with T gel 50 and 100 mg/day, respectively, resulting in a small, but significant, increase in the serum dihydrotestosterone/T ratios in the two T gel groups. Serum estradiol rose, and serum LH and FSH levels were suppressed proportionately with serum T in all study groups; serum sex hormone-binding globulin showed small decreases that were significant only in the 100 mg T gel group. We conclude that transdermal T gel application can efficiently and rapidly increase serum T and free T levels in hypogonadal men to within the normal range. Transdermal T gel provided flexibility in dosing with little skin irritation and a low discontinuation rate.


The gel only showed bioavailability of 9-14%, and the patch around 10% (5-10mg T/day from 50-100mg patches).

 

[lord_regulator]

It all depends on the type of transdermal used in the process IE DMSO, Phlojel, and some others. Some people say you get anywere from 20-80percent absorbtion. Well the only way to know for sure is to do both and i can persoanlly say i have done test propinate injection before did 150mg Monday Wednesday & Friday. Stacked with injection of Primo at 300mg Per Week. Receptors were fresh from a 6 month lay off and put on the average about 16 pounds and about a 8 pound fat loss. over 6 weeks. had a real strict diet to. Did the same amounts all the same amounts of both drug about 1 year later fresh recopters clean diet and gained about 10 pounds and lost about 14 fat. Gained less muscle but lost more fat.

I will be over the next 6 months experimenting using transdermal with various drugs and posting resluts and pictures just for scientific reasons. I guess i will be the scientific guine pig for all

 

[ryamigo]

I take injectable primo. I was wondering if you could mix something like Phlojel with the primo i already have or if I would need to get oral primo and crush it up. The post was not clear on that. Also, How much phlojel or DMSO would I have to mix with whichever form of primo? is it mg for mg? does it make a difference which steroid I use...would the formula still be the same?

 

[uRAN]

trenbolone orally?

Can i take trenbolone orally, and if i can, how much should i take to get the same effekt as injecting 75mg?

 

[Throw2Far]

This is interesting... The transdermal, not the tren oral...

 

[saint john]

an interesting aside. i recently strained my lower back. i applied myoflex topical (salicylate). i waited five minutes and then applied dmso. the pain relief was ten times normal. other strange thing is that although dmso usually makes my breath smell like garlic, this time it didn't.

 

[faaassst]

What brand and strength of DMSO did you use bro?