Things that make you go Hmmmm???

[PBR]

I never bought the "up-reglation" theory. It just doesn't make sense. How can a drug become increasingly more effecive? If that were the case, experienced users would need less and less. That's just not the case. Psuedoscience poppycock mixed with wishful thinking IMO.

nelson...I agree....if this were true, a little AAS would go along way and dosages would be half to a quarter to what experienced users are injesting...I will say one thing on this note: I have noticed that when I start a new cycle, I show signs of being "ON" in a matter of DAYS, where as it used to be weeks before I would feel anything and wondering if my products were real or not....and it can be anything also, any type of AAS will show action within days of injesting for me now....what would you attribute this to??? (sensitivity)...thanks for your input and time.....

 

[Nelson Montana]

There is a certain sensitivity issue and AAS aren't alone in that. Somehow the body recognizes the presense of the drug quicker. This is very noticable with pot. The first few times people try it -- nothing, then after the third time...BAM. But that still doesn't discount the tolerance factor. The body will always try to remain in homeostasis and attempt to build up an immunity to any outside influence.

 

[variation]

insulin also lowers SHBG...

pot, while I dislike and have no interest in it anymore, the first time I used it I was the highest I've ever been off it...

 

[ThirdEye]

insulin also lowers SHBG...

pot, while I dislike and have no interest in it anymore, the first time I used it I was the highest I've ever been off it...

uh, that was the crack you're thinking of.

just joking

 

[granby140]

same with me, the first time i smoked i thought i was flying. Could never duplicate that high so i gave it up.

 

[ungbygger]

There is a certain sensitivity issue and AAS aren't alone in that. Somehow the body recognizes the presense of the drug quicker. This is very noticable with pot. The first few times people try it -- nothing, then after the third time...BAM. But that still doesn't discount the tolerance factor. The body will always try to remain in homeostasis and attempt to build up an immunity to any outside influence.

Yep!

First time, nothing.. second time, high as shit
After a year or so of ED smoking, i could smoke and smoke all night without getting real high.. After a few months off; high again in a few hits!

Think my pot-receptors are worn out

 

[Deleted member 33117]

Nelson, I would agree if we were talking theory... I don't like the shitty pseudo-scientific garbage proposed by many bodybuilders with no real scientific background. I was refering to what scientist have discovered about AR upregualtion based on dose in double-blind studies. AR upregulat based on dose, and very rapidly. Of course they haven't tested anything over 600 mg of test per week as of yet.

ung, I think compairing androgen activity in the body to smoking pot is a very poor comparison.

 

[ungbygger]

Nelson, I would agree if we were talking theory... I don't like the shitty pseudo-scientific garbage proposed by many bodybuilders with no real scientific background. I was refering to what scientist have discovered about AR upregualtion based on dose in double-blind studies. AR upregulat based on dose, and very rapidly. Of course they haven't tested anything over 600 mg of test per week as of yet.

ung, I think compairing androgen activity in the body to smoking pot is a very poor comparison.

Yeah, i know.. bad comparison, and out of line, didnt mean to spoil a good thread.

Have heard of few who started to loose muscle on a few hundred mg`s a week after a while on, and they should grow on that dose.. Either its downgrading of receptors, or the body trying to remain in homeostasis, it seems like you still need more after a while on, but the thread is interresting!

 

[Deleted member 33117]

I think the reason for that is the body trying to stay in homostasis. Muscle growth requires anabolic activity to exceed catabolic activity. Once the receptors upregulate to accomidate the higher test level (and science nows tell us they do this, so until new evidence shows up, and it could, that shows otherwise, should we not say they probaby do?), the higher level does NOT become more anabolic. As you grow larger, your body does become more catabolic, so it becomes more difficult to gain new size. Eventually if you stay on the same dose (and do not find another means to increase anabolic activity or reduce catabolism), and have surpassed your natural limit, of course you will stop growing, once catabolic activity = anabolic activity.

Ung, all is forgiven, and you are correct about pot, as anywho who has smoked it can attest too. The same is true of alcohol.

 

[nadr7891]

IMO if drug companies wanted to focus on creating kinder, gentler and more effective steroids (or supplemental drugs to make existing steroids work better) they could easily do it. these are very old drugs. but, there's more money in other types of drugs and steroids carry a stigma because of so much abuse. so they spend their R&D on other shit.