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theory why primo causes hair loss

AlwaysOn said:
I have a theory, which I will bet is correct.

If you run primo by itself or with other NON-aromatizing substances, you will get hair loss.


If you run primo with aromatizing substances, you will not suffer from hair loss.


Estrogen is necessary for hair maintenance

This is just a theory


yea, not true. Primo is a DHT derivative that's why some folks suffer hair loss, whether they take test or not with it. Not all suffer from hair loss, I love primo, especially a gram a week, and no hair loss, and I take Primo alone as when I take Primo, it's usually cause I want a side free cycle with no water retention, adding an aromatizing drug to it defeats the purpose. Check the profiles, will tell you lot's about primo and how it effects everyone alone and with other bulking and cutting drugs.
 
riverrock said:
Primo ripped my hair to shreads.


I hear that from time to time, it's usually REALLY BAD, or none at all from all my bro's. I dont get ANY at all, but some clog the drain...it's really who is susceptible to MPB. Profiles actually say Primo is very mild on the hair line but I be you would argue that point :)
 
indy69camaro said:
yea, not true. Primo is a DHT derivative that's why some folks suffer hair loss, whether they take test or not with it. Not all suffer from hair loss, I love primo, especially a gram a week, and no hair loss, and I take Primo alone as when I take Primo, it's usually cause I want a side free cycle with no water retention, adding an aromatizing drug to it defeats the purpose. Check the profiles, will tell you lot's about primo and how it effects everyone alone and with other bulking and cutting drugs.


sorry, but have no idea what your talking about.

I bet you don't even understand what a dht derivative is!

Primo is almost identical TESTOSTERONE is structure, so don't give me this DHT derivative B.S.

Primo is NOT close to DHT in structure.
 
I'll simplify, if your prone to MPB and you juice, your will lose your fucking hair faster than if you weren't using...(unless, a big maybe - propecia works for you)...

trust me.
 
mightymouse69 said:
I'll simplify, if your prone to MPB and you juice, your will lose your fucking hair faster than if you weren't using...(unless, a big maybe - propecia works for you)...

trust me.

Now that's an answer... ;)
 
AlwaysOn said:
sorry, but have no idea what your talking about.

I bet you don't even understand what a dht derivative is!

Primo is almost identical TESTOSTERONE is structure, so don't give me this DHT derivative B.S.

Primo is NOT close to DHT in structure.

EDITED, Not worth the response...
 
AlwaysOn said:
sorry, but have no idea what your talking about.

I bet you don't even understand what a dht derivative is!

Primo is almost identical TESTOSTERONE is structure, so don't give me this DHT derivative B.S.

Primo is NOT close to DHT in structure.

Hey bro, Indy is a knowledgeable bro. He's used Primo as much as anyone on this board. Him and Satch are the Primo experts. Back off dawg. By the way, I don't know where you're getting this "theory" of yours. Where's your evidence?
 
Makavelli said:
Hey bro, Indy is a knowledgeable bro. He's used Primo as much as anyone on this board. Him and Satch are the Primo experts. Back off dawg. By the way, I don't know where you're getting this "theory" of yours. Where's your evidence?


Thanks my friend, Let me know if he comes up with better evidence than I posted, he's in my ignore list now, so his posts are invisible to me.......he's not worth the time with responses like that.
 
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Goodfellow said:
Primo is a dht derivative.


wrong, primo a DHB derivative.

DHB is also known as the "prohormone" 1-testosterone.

And guess what DHB/1-testosterone's structure is pretty much exactly like testosterone.
 
Dht Causes Hairloss Not Testosterone

Goodfellow said:
Primo is a dht derivative.


Primobolan
________________________________________
Pharmaceutical Name: Methenolone (orally as acetate, injections as enanthate)
Chemical structure: 17 beta-hydroxy-1-methyl-5 alpha-androst-1-en-3-one
Effective dose: 200-300 mg/week injections or 50-150 mg/day orally


Primobolan is a well-known and popular steroid as well. Like nandrolone it's most often used as a base compound for stacking with other steroids. Methenolone however, is a DHT-based steroid (actually, DHB or dihydroboldenone, the 5-alpha reduced of the milder boldenon). Meaning when it interacts with the aromatase enzyme it does not form estrogens at all. That makes it ideal for use when cutting when excess estrogen is best avoided because of its retentive effects on water and fat. Methenolone is mostly only used in such instances, or by people who are very succeptible to estrogenic side-effects, because the anabolic activity of methenolone is slightly lower than that of nandrolone, quite likely BECAUSE it is non-estrogenic.

Because it is a widely available steroid its often used as a replacement for nandrolone or boldenone to those who have no access to Deca-Durabolin or Laurabolin or Equipoise. When stacked with a heavy mass steroid like testosterone and/or methandrostenolone it can deliver almost similar gains. Those seeking to cut will most likely be very pleased stacking it with drostanolone, stanozolol or trenbolone. Women and beginners also stack methenolone WITH nandrolone because this gives a mildly anabolic stack that is generally regarded as one of the safer stacks around in an androgenic perspective. But alas, with the nandrolone, also a very suppressive stack.

Methenolone is available as an injection or as an oral. The injection is naturally regarded as better. Its an enanthate ester which is quite long-acting and only needs to be injected once a week in doses of 300-600 mg. Because it by-passes hepatic breakdown on the first pass, it also has a higher survival rate. The orals are a lot less handy, but often preferred by bodybuilders who are afraid of needles or who are already taking one or more injectable compounds. The tabs are in a short-lived acetate form, meaning that doses of 100-150 mg per day are needed, split over 2 or 3 doses, making the tabs quite inconvenient for use. The reason doses need to be split up, unlike most oral steroids, is because Methenolone is not 17-alpha-alkylated, but 1-methylated for oral bio-availability. This reduces the liver stress, but also the availability, hence the multiple and high doses needed daily.

Like nandrolone, methenolone is very mild on the system. Probably the reason why both are strongly favored as base compounds in stacks. Methenolone has no estrogenic side-effects whatsoever, on account of its structure. Its effects on the cholesterol levels are barely noticeable. In doses of 200 mg or less (injectable) blood pressure is rarely, if at all, altered. As for hepatoxicity, long-term use will of course increase liver values but gradually and only slightly. The injections of course, since they only pass the liver once, have roughly half the liver-toxic effects of the tabs. The low liver-toxicity is accounted for that the bio-availability of methenolone is carried by a 1-methyl-group, which lessens the need for a carrier attachment such as a 17-alpha-akylated group, the main culprit in steroid-related liver afflictions.

The strangest thing however, taking into account that Primo is still a DHT (or rather DHB) derivative, is that it is quite easy on the system androgenically as well. Women use methenolone often, usually the tabs, and find little virilisation symptoms in short term use of methenolone. Long-term use may induce some acne and a deepening of the voice however. Methenolone is also not overly suppressive of the HPT axis (endocrinal axis for the production of natural testosterone). These are both the result of DHB's 1,2-double bond, which, analog to the parent structure boldenone, reduces the androgenic binding by 50% as opposed to DHT.

For athletes who wish to maintain a "natural" status in competition, the tablets are quite well-suited as detection chances for the acetate-form are quite slim. However tests have improved and quite a number of metabolites1 of methenolone can be detected with a simple urine sample. But an English study documented that there is a liability in eating methenolone contaminated meats2, which could provide a possible defense if found out. One could always claim they ate the meat of a chicken or cow injected with methenolone since the test concluded eating such meat does not improve performance, but can deliver positive tests for several methenolone metabolites almost 24 hours after ingestion. That's for those of you seeking a viable defense against a possible methenolone-positive.

Methenolone comes in orals and injectables. The injectables are to be preferred as they can be used for quite some time and only require injecting once a week. The orals are taking every day, or multiple times a day. An oral passes through the liver twice. An injectable only once. The injectable is more effective since less is broken down.

Methenolone is not used all that often by experienced users. It makes a good product as an alternative to Deca or EQ in a cutting stack, because it has similar properties but does not aromatize and does not have progestagenic activity. But those at least slightly versed will prefer boldenone over methenolone as its more potent gram for gram. Its quite mild, so its not as prone to cause your standard side-effects. This too makes it quite popular with beginners. Methenolone was quite popular during the 70's in stacks with Methandrostenolone. Some of the all-time greats of bodybuilding were quite fond of this stack. The common use is similar to that of Nandrolone. 300-400 mg a week, in conjunction with other steroids mostly. Some attempt to make up for the lack of potency switching from nandrolone or boldenone to methenolone by using higher doses, in the neighbourhood of 600-800 mg a week. At that point I feel it would be cheaper to opt for boldenone at 300-400 mg a week though. Methenolone makes a poor stacking partner in mass stacks as both Deca and EQ provide better results while they are qualitatively similar. There is a slight merit in stacking Methenolone with boldenone, because apart from its 1-methyl group, methenolone is basically DHB, the 5-alpha-reduced form of boldenone. But since boldenone itself has very low affinity for 5-alpha-reduction, it should have a good synergistic effect stacking the two at 300 mg/week each.
 
Ok so now you admit, primo is derivative of the "prohormone" 1-testosterone also known as DHB (also known as the reduced form of the base steroid of equipoise).

So now we can proceed with what I posted in my original post.
 
AlwaysOn said:
Ok so now you admit, primo is derivative of the "prohormone" 1-testosterone also known as DHB (also known as the reduced form of the base steroid of equipoise).

So now we can proceed with what I posted in my original post.


JESUS CHRIST, Dont tell me Ross is back again........
 
dude,YOU are the one who posted the info lol

"There is a slight merit in stacking Methenolone with boldenone, because apart from its 1-methyl group, methenolone is basically DHB, the 5-alpha-reduced form of boldenone..."


anway, back to my theory...

I have noticed that primo, winny and yes there ARE some reports of people shedding on anavar.

All of these are non-aromatizing substances. just an observation.
 
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Alwayson if your theory was true then woman would never experince hair loss when taking primo. I can swear by the fact that it thinned out my hair. Thank the lord I have thick hair.
 
superqt4u2nv said:
Alwayson if your theory was true then woman would never experince hair loss when taking primo. I can swear by the fact that it thinned out my hair. Thank the lord I have thick hair.

Shit!!! Now thats not good.
 
Your theory is wrong dude.

If estrogen was needed for hair maintenance then children would go bald because basically they don't have any estrogen.
 
AlwaysOn said:
go ahead dude, and PM me if you want to.

nothin personal,

its just that primo is NOT a DHT-derivative,


Everything I read online and what I learn from the vets on here and a few other boards tells me you are wrong. If you have some profile or info to prove you are correct, then post it. Just because you say it isn't doesn't make you right and a good portion for the basis of a theroy are some facts to form said theory. Indy is a pretty intelligent fellow overall and he has a good amount of experience and knowledge with Primo, so you really need to "lay out your spread" or shut up. Like you said it's nothing personal, but if you are going to disagree with someone that's fine, we don't all have to agree. But debate don't just start saying he's wrong or start insinuating he is stupid and not back it up. I had to put one newbie in his place for pulling the same crap last week, and I won't hesitate to do it again. Debate and learn, don't just insult.

*deep breath*

NOW.........please post up your rebuttal. (what I mean by rebuttal is posting up your information and/or facts (not insults) that would dispute the information that Indy has put up)
 
Herbiv0re said:
Why are you guys dissing someone who is right?
Methenolone is not a DHT derivative, period.


Well according the the profiles I am reading online and other sites, you are not correct. The profile Indy put up on page one is a good example, and the counter point to your statement is in bold towards the begining. Where are you getting your information and please post it so we can see both sides of the argument.
 
AlwaysOn said:
Ok so now you admit, primo is derivative of the "prohormone" 1-testosterone also known as DHB (also known as the reduced form of the base steroid of equipoise).

So now we can proceed with what I posted in my original post.


Lets address the first issue at hand....

DHB is a compound that basically makes up DHT. Making primo a DHT derivative. Its just that simple.

You cant compair Primo to a 1-test product. Is the chemical make up similar..yes..but different. If it was the same then why do you bloat and get so much water retention on 1-test. Do you get that with Primo....NO!

Second problem.....
Dont start calling people out to start an argument over PM's Good way to get your self banned...And honestly calling Indy out...Thats just barking up the wrong tree. Im not starting anything with you or trying to be agressive..but i consider Indy a friend..and he is friends with alot of people here..ok everyone one of importance here. Just drop it...

Primo is a DHT derivative.
 
LftHndPwrHouse said:
Second problem.....
Dont start calling people out to start an argument over PM's Good way to get your self banned...And honestly calling Indy out...Thats just barking up the wrong tree. Im not starting anything with you or trying to be agressive..but i consider Indy a friend..and he is friends with alot of people here..ok everyone one of importance here. Just drop it...

Primo is a DHT derivative.


lol, I DID drop it all the way on page one!!


OTHER people are taking up my cause!

Again, what did I do wrong that I am getting negaitve karma and bombs..lol

I was just trying to educate you all, after all I am a fucking BIOCHEMIST.

I teach this stuff to my students all the time...lol
 
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Hey, Indy and board!

I apologize if my language was coarse.

AGAIN for the third time, it was nothin personal against anyone. (I keep trying to drop it, but you guys keep bringing it up. )

Just a bad choice of words.

I respectively disagree, that primo is a DHT-derivative.

Hell, your "sacred profiles" agree with me that it is a DHB derivative which is totally different than DHT in structure if any of you actually bothered to compare the two. :rolleyes:
 
AlwaysOn said:
lol, I DID drop it all the way on page one!!


OTHER people are taking up my cause!

Again, what did I do wrong that I am getting negaitve karma and bombs..lol

I was just trying to educate you all, after all I am a fucking BIOCHEMIST.

I teach this stuff to my students all the time...lol


Well, I appreciate you taking a change in your approach. I do have a question for you......and it's hard to say without sounding as though i am calling you a liar so for the record I am not. However, I find it hard to beleive that you, a "biochemist" , doesn't have a buttload of scientific data or factual information to condradict these "sacred profiles" as you called them. I have 2 friends that work in the science and research field and they would of bored me to death with fact after fact to support their theory. If you are in fact a biochemist then I think I can speak for a lot of the members when I will ask you again to please post some information with more substance instead of just disagreeing. I am here to learn and primo does interest me. The more I can learn about it the better. I look forward to your reply.
 
AlwaysOn said:
Hey, Indy and board!

I apologize if my language was coarse.

AGAIN for the third time, it was nothin personal against anyone. (I keep trying to drop it, but you guys keep bringing it up. )

Just a bad choice of words.

I respectively disagree, that primo is a DHT-derivative.

Hell, your "sacred profiles" agree with me that it is a DHB derivative which is totally different than DHT in structure if any of you actually bothered to compare the two. :rolleyes:

Apology accepted, I am happy you stepped up and did so. I cannot see your posts due to my ignore list, but other bro's let me know, and I removed you from it, much appreciated. Now please read post #25 it uses more exact phrasing than I did, and the person that posted is overly qualified to answer that question, yet it is not by business to disclose what his profession is. What he posted is what I was getting at, but I'm no doc so cannot word it as well as I would have wanted to.

To answer your other questions, you were being quite brisk to say the least and I think wayneboard1 summed up the other issues enough that I dont have to repeat. Once again read the post by lfthndpwrhouse and respond to that accordingly, I dont see how you could disagree with his clarification.
 
Okay guys, bashing over. Give the guy a break. Debate is encouraged on this board. He admitted he should have chosen the wording of his initial argument better. Apology has been accepted by Indy, so PLEASE don't drop a 4th bomb, and give the guy a chance to make his points.
 
riverrock said:
Okay guys, bashing over. Give the guy a break. Debate is encouraged on this board. He admitted he should have chosen the wording of his initial argument better. Apology has been accepted by Indy, so PLEASE don't drop a 4th bomb, and give the guy a chance to make his points.

I agree, I'm very easy to get along with..........consider this post a bump to the top
 
wayneboard1 said:
Well according the the profiles I am reading online and other sites, you are not correct. The profile Indy put up on page one is a good example, and the counter point to your statement is in bold towards the begining. Where are you getting your information and please post it so we can see both sides of the argument.

What about reading what is not in bold in the profile...
What about looking up methenolone's structure...

I'm out.
 
Guys, I didn't start this thread to debate whether primo is a DHT derivative.

I just seemed to notice that the non-aromatizing substances cause hairloss i.e. tren, winny, primo and yes I even heard of shedding on var. And in these cases, the guys were running the compounds by themselves, thus they had zero estrogen.

I was just thinking maybe estrogens play some sort of role.

That's all..


Do you know whats funnny, I recieved way more POSITIVE karma than negative karma....thanks to everyone who gave me positive karma and the kind words.
 
Do you know whats funnny, I recieved way more POSITIVE karma than negative karma....thanks to everyone who gave me positive karma and the kind words.[/QUOTE]

That can easily be changed. :D I'm done with this thread and for the record, I believe Indy is right. There has been no facts or information to say otherwise just a bunch of talk.
 
wayneboard1 said:
Do you know whats funnny, I recieved way more POSITIVE karma than negative karma....thanks to everyone who gave me positive karma and the kind words.

That can easily be changed. :D I'm done with this thread and for the record, I believe Indy is right. There has been no facts or information to say otherwise just a bunch of talk.[/QUOTE]

I've gotten over 400 Karma points myself just from people blasting him for acting like that.....He still doesn't respond to the other posts, or that I asked him to check out #25 or anything. He apologized, that's cool, but I am done with the thread as well, we're still not getting anywhere, he's just being a little nicer......Consider me unsubscribed bro's.
 
AlwaysOn said:
go ahead dude, and PM me if you want to.

nothin personal,

its just that primo is NOT a DHT-derivative,


If you read...I NEVER SAID YOU DID PM ANYONE!!!!!!!!!!...

but that quote from you says...go and PM me....does it not....and in the nature of which you are talking...that seems like the PM would be in an aggressive nature!!

So before you start handing out RED KARMA...why dont you read!

I never accused you of doing anything..All i did was point out your aggressive attitude and what seemed to be a personal attack pointed at INDY!
 
Okay, after discussing this with a friend who is better than I am in synthetic chemistry, I have to admit that I am wrong in some way.
Since boldenone is in itself derived from Testosterone , 5-alpha reduced boldenone can be considered as being derived from DHT.

Sorry for insisting.
But I do maintain that methenolone is 1-methyl dihydroboldenone :mix:
 
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Herbiv0re said:
Okay, after discussing this with a friend who is better than I am in synthetic chemistry, I have to admit that I am wrong in some way.
Since boldenone is in itself derived from Testosterone , 5-alpha reduced boldenone can be considered as being derived from DHT.

Sorry for insisting.
But I do maintain that methenolone is 1-methyl dihydroboldenone :mix:

Please send this to the all knowing "alwayson" maybe he will believe you, sure doesn't us ....
 
Primo is actually a DHB derivative. DHB is what EQ reduces to. Although EQ reduces in relatively small amounts, it is and has been the culprit in some severe hair loss cases. Just like with primo, EQ is usually mild on the hair, but when it strikes, it strikes hard. The mechanism for which EQ and primo cause hair loss is not very understood, but they are related (since primo is a derivative of dehydroboldenone), and most undoubtedly affect the hair in similar ways. There is really nothing you can do to stop it if you're one of the unlucky ones.
 
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