In the case of UNLEASHED, since in=the increase is in FREE testosterone, there's no down regulation. That's like saying if you use too much Vitamin C, it will down regulate your response to it. No, you'll uses what you can, and the rest is discarded as waste.
Some guys like to take a break so when they go back on they feel that "kick." But the use of HCGen and N2GUARD on cycles, and UNLEASHED for PCT and Bridge in between cycles, provides a nice change of pace -- all the time enhancing and continuing the effects of the cycle.