Let me explani something to you gentlemen, higher doses of T3 do NOT increase protein synthesis.
" Interestingly, we failed to observe changes in protein turnover and synthesis, which would be expected with elevated thyroid hormone levels. This result may be due to the timing of the leucine kinetics studies, which were performed at baseline and after 9 weeks of treatment (a point when changes in N balance were minimal). Changes occurring at shorter (<6 weeks) intervals may have been missed by this protocol. Previous studies with higher doses of T3 (100 µg/day) detected significant changes in whole body leucine oxidation and protein breakdown after 2 weeks of treatment (24)."
Metabolism 1981 Aug;30(8):783-91
Whole body leucine and lysine metabolism studied with [1-13C]leucine and [alpha-15N]lysine: response in healthy young men given excess energy intake.
Motil KJ, Bier DM, Matthews DE, Burke JF, Young VR.
From my experience you will get more out of 12.5mcg than you would out of 25mcg. At 12.5mcg, you can fell your body being more effective, at 25mcg you simply feel like shit.