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C0LUMB0
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He is posting here for 10 years.
With 14 posts under your belt - you are in no position to tell anybody to refrain from posting.
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Synovex conversion
- Thread starter NMuir
- Start date
He is posting here for 10 years.
With 14 posts under your belt - you are in no position to tell anybody to refrain from posting.
We respect everybody's opinion here i strongly suggest you do the same.
Ox-Sandra-Loan
New member
just what are you suggesting here? extract with diethylether? good thing you've got strong arms cuz youre gonna be shaking for hours to dissolve it out of a methanol solution, and its never gonna separate. the whole purpose of the water drip is the precipitate the tp so it can be filtered, you'd need literally litres if not gallons of ether at that temperature to dissolve the ppt'd tp.
TP is very soluble in Et2O. I am saying to extract is from the synovex pellets with ether, not from any methanol solution.
hydrolyze the base, ok, that forms propanoic acid which then reacts to use up your carefully measured sodium hydroxide thus not allowing it to react with the phenolic hydroxyl leaving estrogen in the final product.
alcohol-water is not a recrystallization with respect to tp it is a precipitation, to get xtals you must dissolve and use cooling to bring out the clear needles.
Methanol-water works just fine if you do it properly. I am talking about re-crystallization, NOT precipitation. Use the correct amount of each.
prepatory columns are generally used in synthesis, you already have pure tp you are just simply partitioning it based on solubility from the testp, its already pure, you don't even need to recrystallize it , fun to use big words and terms though. just kidding around lol
It's obviously NOT already pure if it is in implants with fillers and binders and also contains estradiol benzoate. If a person is going to be injecting this, I think they would want it pure. Preparatory columns are used to separate components in a mixture, and that is quite obviously NOT just used in synthesis. Fun for you to pretend you know what you are talking about though...j/k
kits are unneccessary, this is just too easy and you can make a better kit on your own thats less likely to cleave the propionate ester by utilizing calcium hydroxide instead of sodium hydroxide, it just may take a little longer to dissolve the calcium hdyroxide prior to use. buy the following:
-distilled water
-methyl hydrate, methanol, same shit different name
-calcium hydroxide, plant store, remember it has twice the ability to form the salt with phenolics as lye so only half the relative amount is needed
-coffe filters or a manual centrifuge
-a one litre pyrex beaker
-a hot plate
to figure out how much of each thing you need go to google and type in molecular weight of test prop, then calcium hydroxide, then estrogen or estradiol etc.. and finally sodium hydroxide. molecular weight makes everything relative, like a handicapping. so to find out the calcium hydroxide you need:
grams of estrogen in sample to get rid of * 1/molecular weight of estrogen = number moles you have X
X moles estrogen * molecular weight of calcium hydroxide in grams/mole = grams needed of calcium hydroxide BUT remember you only need half that as calcium hdyroxide has two hydroxides in every molecule so it does twice the work per mol so cut that number in half and thats the grams of calcium hydroxide needed.
That will form the calcium phenol half-salt, which is not sufficiently basic enough to react with another phenol group to form the diphenolate salt. Remember, the salt is formed from the cation, the hydroxide just serves to deprotonate the phenol to allow it to form the salt. This would work if you had another base (triethylamine maybe?) to deprotonate the -OH to allow it to form the diphenolate salt.
if you use exact amounts there is no reason to fear the cleavage of tp as the reactioin with the phenolic estro is thermodynamically favorable and happens first leaving no calhydrox for cleaving the tp.
This method won't leave any calcium hydroxide, right...but it will leave some estradiol.
for methanol you use whatever it takes to dissolve your material.
everyone here can do this without needing to buy a magic dissolving solution (i'm sorry i find that so offensive), if you can negotiate the internet you can make your own kit and effectively utilize it
replies in bold
by the way, people use technical terms because they serve a purpose and have a particular meaning, not to try to make themselves sound smart. A big part of education is learning the language in that field. Why people at gyms say "10 reps" instead of "pick it up and put it down 10 times" is no different.
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chembeaker
New member
I need clarification on your meaning of methanol-water. Are you saying you are heating in a mixture of methanol and water and fractionally crystallizing or dissolving in rt methanol and going through dropwise addition of water? I apologize if I misunderstood, yes you can crystallize that way but still nothing compares to dissolving in rt methanol and giving it a week to evaporate, obtaining glass like crystals with steroids is difficult and can't be done in the presence of water, thats all i am saying, a crystalline powder is very possible if done right.
in literature such as merck it states that tp is soluble in ether, in practise it isn't quite so soluble outside perfect world conditions, after all this is the book that says a gram of lithium dissolves in ten ml of ammonia gas condensed, in a oxymethalone synth i counted on that solubility and was very sadly let down when it required over five times that volume. anyway again i misunderstood and yes what you describe will work, i just don't think its that simple. chloroform when hot is a nice solvent, i always formed my esters by dissolving the base in chloroform and pyridine and refluxing with acetic anhydride, phenylacetic anhydride, phenylpropanoyl chloride etc.. and as soon as the temperature decreased to a certain temp it was like wham and nice solid lump that you could decant off of and dump in methanol to crystallize. You might be able to appreciate, or will be able to i guess, the significance of one ester we prepared, the 3,4 methylenedioxyphenylacetate ester of nandrolone lol.
if calcium hydroxide is not strong enough to form the diphenolate with estradiol i can only take your word as a fellow chemical scholar that it is so. in methanol I have never had issues with stoiciometric use of caoh2 with morphine derivs. i have never seen the need to go through this procedure when dhea is everywhere, all you ever need can be synth'd from dhea, of particular ease is test, methyltest, methandro, boldenone, even drostanolone, the syntheses are easier than the conversion from implants.
the purity of the product, again we agree to disagree, the excipients of synovex are either water soluble or alcohol soluble or other, that which is soluble in methanol is usually also soluble in water (many exceptions ) usually pill matter is not alc soluble so when you dissolve in methanol filter through a good tight whatman and there that goes, remaining dissolved in methanol will likely be soluble in water to a greater extent and will stay dissolved when the tp is ppt'd, besides a recryst from methanol will keep any solubles dissolved and xtallize only tp which is filtered and crystallized from methanol again. the purity i refer to is that there is no left over synthesis chemicals or androstenedione=ol or dht, its pure tp. besides there is nothing toxic in synovex, thats why its for internal use.
i really appreciate this intelligent argument, its nice to run into other hot headed chemists out there, we are very opinionated. I'm an SFU BSc biochem MSc org synth and VanisleU DPPC gone rogue illicit retard, don't use this shite, its for the birds, i have great interest in their synthesis and dist. though. Yourself?
If you are interested in any of the notes from synthesis attempts that were deamed successful I'd happily pm them to you, most are totally otc and kitchen friendly. Lots of them are here on ef, i used to post under a different name.
Wow, there are so many different ideas about how to do this out there. I have converted fina with great results and am just trying syno for the first time. I purchased a 10G kit from MonsteXXXXXa with 5CCs if an "estro-solubilizer". Dissolved my pellets in HEET, added the estro-solubilizer, waited the prescribed hour (with some precipitate, but I read that was okay and expected), then "slowly" added about 500cc of sterile water. I filtered out the powder using 2 HEPA masks. After drying for 3 days, i weighed the chalky white powder and it weighed 28g. I should have, at best, ended up with 20g of test prop powder. I am going to use more methanol (HEET) and repeat the process, more slowly with ice water now. I assume my extra weight may have been a little water still in the powder, although it was pretty dry. This is component e-h Im talking about here, just to be clear. At no point did i end up with clear crystals. When i added water to my solution before filtering, there were what appeared to be long (3mm-ish) thin crystals but they weren't in tact when i filtered out the test. I am thinking that repeating the process with chilled water will give me the crystals that i expected. Any suggestions? No need to point out that i really dont know what im doing, this is clearly a science experiment and i realize i may have to try a couple of times before getting it right. thanks all
there is a forum specifically for homebrew--may find more answers there--lots of knowledgeable bros there.
Thanks, i went ahead and repeated the process, a lot slower with chilled water and with the methanol sitting in an ice bath in a beaker. The crystals looked great, but since the methanol was in an ice bath they all formed on the bottom. I took it out and just added chilled distilled water (to the methanol and test solution) and saw the crystals growing throughout. Ill post with my final product weight. Thanks for the responses and not blasting me on my first post.
