Shbg

[madmitch]

SHBG or Sex Hormone Binding Globulin is very important when it comes to finding out how effective your steroid cycle will be.

Why?

Well the level of SHBG in your blood, to a degree controls the concentration of free Testosterone, DHT and Estrogen.

High SHBG levels are found in cases of Hypogonadism, ANDROGEN INSENSITIVITY / Deficency and Alcoholic hepatic cirrhosis.

Ok so what happens when you start taking extra Testosterone. Well it becomes a bit complicated, at first the extra Testosterone can actually lower your SHBG levels, sounds good right. This means you should actually free up some more of your natural testosterone that was bound to the SHBG.

However good things don't last for ever.

As the Testosterone or Steroids begin to aromatise to Estrogen things are reversed, because increasing levels of estrogen also increases levels of SHBG.

Therefore as SHBG levels increase more and more of the your Testosterone and Steroids become bound to SHBG. To make matters worse the two Hormones that bind most tightly to SHBG are DHT and Testosterone, followed by Androstenediol and then Estradiol (Estrogen).

This eventually will creat an imblance in your Testosterone to Estrogen ratio. i.e. More and more SHBG is produced as a result of excessive levels of estrogen which in turn soaks up more and more of the extra Testosterone that you are taking.

Remember Estrogen is only 4 th on the list of Hormones that SHBG likes to bind with, so it prefers your Testosterone to Estrogen.

This means that it would be more advisable to use an Aromatase inhibitor like Cytadren or Armidex during your cycle than just an Estrogen blocker like Nolvedex.

One other thing, Clomid actually increases your SHBG levels where'as Nolvedex does not.

 

[serge]

SHBG or Sex Hormone Binding Globulin is very important when it comes to finding out how effective your steroid cycle will be.

Why?

Well the level of SHBG in your blood, to a degree controls the concentration of free Testosterone, DHT and Estrogen.

High SHBG levels are found in cases of Hypogonadism, ANDROGEN INSENSITIVITY / Deficency and Alcoholic hepatic cirrhosis.

Ok so what happens when you start taking extra Testosterone. Well it becomes a bit complicated, at first the extra Testosterone can actually lower your SHBG levels, sounds good right. This means you should actually free up some more of your natural testosterone that was bound to the SHBG.

However good things don't last for ever.

As the Testosterone or Steroids begin to aromatise to Estrogen things are reversed, because increasing levels of estrogen also increases levels of SHBG.

Therefore as SHBG levels increase more and more of the your Testosterone and Steroids become bound to SHBG. To make matters worse the two Hormones that bind most tightly to SHBG are DHT and Testosterone, followed by Androstenediol and then Estradiol (Estrogen).

This eventually will creat an imblance in your Testosterone to Estrogen ratio. i.e. More and more SHBG is produced as a result of excessive levels of estrogen which in turn soaks up more and more of the extra Testosterone that you are taking.

Remember Estrogen is only 4 th on the list of Hormones that SHBG likes to bind with, so it prefers your Testosterone to Estrogen.

This means that it would be more advisable to use an Aromatase inhibitor like Cytadren or Armidex during your cycle than just an Estrogen blocker like Nolvedex.

One other thing, Clomid actually increases your SHBG levels where'as Nolvedex does not.

i always said that was the reason the gains come to a hault while on the cycle, however if you take a 2 week break and reaload your gains resume running the same doses of gear prior to the break; taking aromatise inhibitor off-sets the SHBG buildup

 

[madmitch]

One more thing, Growth Hormone lowers SHBG levels another reason why Growth Hormone would increase the effectiveness of your steroid cycle.

 

[madmitch]

Some people have wrote that DHT isn't really that bad as it has a greater affinity for SHBG than Testosterone i.e. higher levels of DHT will displace more Testosterone.

Well to a point this would be ok, but if more and more of the Testosterone that is freed is being converted to Estrogen you will get more and more SHBG and thus need more and more DHT to bind to the SHBG.

Take note: Most Men in their 60's have High levels of SHBG, High levels of DHT, Low levels of Testosterone and High levels of Estrogen, in some cases a 60 year old man has more Estrogen than a 60 year old woman.

Young men have Lower levels of SHBG, Low levels of DHT, Higher levels of Testosterone and Lower levels of Estrogen.

Go figure

 

[jcap28]

this is just another reason to use a-dex

oh and, madmitch is right about dht affecting free test thru shbg -- thats why dht based steroids are awesome stacks with T .

 

[abomb555]

then wouldnt one wanna run adex during cycle?