Selank...for stress reduction

[John Juan]

Selanks’ method of action is entirely unique of most other nootropics. It is thought to modulate the concentration of monoamine neurotransmitters. This may have incredible benefits for cognition. Another recognized benefit is its alleged effects on brain-derived neurotropic factor (BDNF)

 

[John Juan]

Selank is able to influence the release of both the neurotransmitter Dopamine and Serotonin.

 

[John Juan]

Selank considered to be immunomodulatory, or capable of improving and changing the immune system for the better.

 

[John Juan]

[Compensatory and antiamnestic effects of heptapeptide Selank in monkeys].

Authors
[No authors listed]
Journal
Zh Evol Biokhim Fiziol. 2008 May-Jun;44(3):284-90. Article in Russian.

Affiliation
Abstract
The work presents results of study of role of heptapeptide Selank--an anxiolytic from group of biologically active peptides--in compensation of disturbed psychic and homeostatic functions in monkeys. New data have been obtained which indicate that an intranasal administration of Selank produces long-term changes of the monkeys' behavior disturbed during neurosis: elimination of fear and aggression and an increase of orientational-explorative activity as well as facilitation of handling reactions and communicational relations. It has been established that on the background of the Selank there occurs a long compensation of disturbed psychic functions (processes of memory) and of homeostatic parameters. It has been shown that unlike the earlier studied neurohormones (thyroliberin and ACTH4-10), the antistressor Selank effects do not depend on the type of neurotic disturbances and have long-term compensatory character. Comparison of the data obtained on monkeys with results of similar studies on the more low-organized mammals (rodents) allow suggesting that the new peptide preparation Selank is a promising agent for correction of various psychoemotional disturbances (alarm- and depression-like disorders).

PMID 18727417 [PubMed - indexed for MEDLINE]

 

[John Juan]

Selank improves quality sleep.

 

[John Juan]

[Experimental optimization of learning and memory processes by selank].

AuthorsSemenova TP, et al. Show all Journal
Eksp Klin Farmakol. 2010 Aug;73(8):2-5. Article in Russian.

Affiliation
Abstract
The effect of selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro), which is a synthetic derivative of the endogenous tetrapeptide tuftsin (stable with respect to tissue peptidases), on the learning and memory processes and metabolism of serotonin (5-HT) have been experimentally studied on Wistar rats. The animals were trained with food reward in 30 trials per day. Selank (300 microg/kg) or saline were injected after the 10th trial. Elaboration of conditioned reflex with food reward was continued 30 min later. Retention was tested 24 h, 7 and 30 days after treatment. A single injection of selank activated the metabolism of 5-HT in the hypothalamus and caudal brain stem for 30 min to 2 h. It was established that selank induces an increase in memory trace stability during 30 days. These findings provide direct evidence that selank, when injected during consolidation phase, can enhance memory storage processes. Nootrope activity of the selank is probably caused by its obvious effect on the level of serotonin and its metabolite in the brain.

 

[John Juan]

[The role of opioid system in peculiarities of anti-anxiety effect of peptide anxiolytic selank].

AuthorsKozlovskiĭ II, et al. Show all Journal
Eksp Klin Farmakol. 2012;75(2):10-3. Article in Russian.

Affiliation
Abstract
Peculiarities of the anxiolytic effects of selank (heptapeptide analog of taftsin) under reduced activity of opioid system upon acute administration of naloxone have been studied in BALB/C and C57BL/6 inbred mice with high and low levels of anxiety, with passive and active emotional stress reaction phenotypes in the open field (OF) test. Selank (0.25 mg/kg, i.p.) per se exhibited anxiolytic effect in BALB/C mice by increasing the general locomotor activity, with no effects on the behavior of C57BL/6 mice in the OF test. Naloxone (1.0 mg/kg, i.p.) per se evoked swift runaway in OF peripheral areas in BALB/C mice while "freezing" the reaction in C57BL/6 mice with active response to stress under the same conditions. Pretreatment with naloxone attenuated the sensitivity to selank in BALB/C mice whereas the response to anxiolytic effects of peptide was increased in C57BL/6 mice. The data obtained reveal a new target for selank in CNS and indicate significance of the activity of enkephalin-opioid system in individual sensitivity to selank.

 

[John Juan]

Selank helps block out background noise allowing one to be more focused.

 

[John Juan]

I interpret this study to be one of those old studies where they give a rat certain choices and if the rat makes the incorrect choice he is punished. This is what they mean by "conditined active avoidance reflex", if I'm not mistaken. This study shows that rats with below normal learning abilities improve rapidly post selank administration.


The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats.

AuthorsKozlovskii II, et al. Show all Journal
Neurosci Behav Physiol. 2003 Sep;33(7):639-43.

Affiliation
Abstract
The actions of the synthetic heptapeptide preparation Selank on learning and memory processes in rats with initially low levels of learning ability were compared with those in normal rats, using a method based on acquisition of a conditioned active avoidance reflex, with repeated administration of peptide 15 min before the start of training sessions for four days. The effects of Selank (300 microg/kg) were compared with the effects of the nootrope piracetam (400 mg/kg). These experiments showed that Selank significantly activated the learning process in rats with initially poor learning ability, with effects apparent after first dose on training day 1. The effect progressively increased on repeated administration of Selank: the total number of correct solutions increased and the number of errors decreased (p < 0.05). The maximum optimizing activity of Selank on learning in normal rats was seen on day 3 of repeated administration and training, i.e., after formation of the initial consolidation phase. The dynamic features of the development of the activating action of Selank and piracetam were described. Comparison of the results obtained here with data on the anti-anxiety actions of Selank suggested potential for its use in optimizing mnestic functions in conditions of elevated emotional tension.

PMID 14552529 [PubMed - indexed for MEDLINE]

 

[John Juan]

With selank your are much more focused on the task at hand which makes you much more efficient at what you are working on .