reducing fat cells sensitivity to insulin

[saintjohn]

anyone know of any supplements or drugs that have been proven to reduce fat cells sensitivity to insulin? i have heard cla, glucosamine and glucorell r for this purpose, but no specific dosage recommendation if the person is currently on an insulin cycle. i had posed this question in a different thread, but i was getting lots of unrelated answers that involved treating hypoglycemia, diet, etc. thanks

 

[SlimJim300]

If you reduce insulin sensitivity in adipose tissue you will also reduce it in the muscle. This is not a good thing. You would think that insulin sensitive fat would make you put on fat more easily (and in one way it does), but the more insulin sensitive you are, the more glucose there will be shuttled into muscle tissue. The less time you spend with raised levels of insulin the less fat you will put on. For that reason, it is better to be all-around insulin sensitive.

If you are using exogeneous insulin, fat accumulation will pretty much happen regardless. In this case it is still better to be in an insulin sensitive state, not only to avoid diabetes, but to make your insulin usage more effective. Supplements like r-ALA are proven to work for this.



-Slim

 

[SlimJim300]

By the way, watch out for articles regarding insulin sensitivity by Big Cat (on bodybuilding.com). He may have a lot of good information to read, but as far as insulin sensitivity goes, he statements are misleading and contradictory.

 

[Indy]

If you reduce insulin sensitivity in adipose tissue you will also reduce it in the muscle. This is not a good thing. You would think that insulin sensitive fat would make you put on fat more easily (and in one way it does), but the more insulin sensitive you are, the more glucose there will be shuttled into muscle tissue. The less time you spend with raised levels of insulin the less fat you will put on. For that reason, it is better to be all-around insulin sensitive.

If you are using exogeneous insulin, fat accumulation will pretty much happen regardless. In this case it is still better to be in an insulin sensitive state, not only to avoid diabetes, but to make your insulin usage more effective. Supplements like r-ALA are proven to work for this.



-Slim

Great post Slim, K to you bro

 

[saintjohn]

If you reduce insulin sensitivity in adipose tissue you will also reduce it in the muscle. This is not a good thing. You would think that insulin sensitive fat would make you put on fat more easily (and in one way it does), but the more insulin sensitive you are, the more glucose there will be shuttled into muscle tissue. The less time you spend with raised levels of insulin the less fat you will put on. For that reason, it is better to be all-around insulin sensitive.

If you are using exogeneous insulin, fat accumulation will pretty much happen regardless. In this case it is still better to be in an insulin sensitive state, not only to avoid diabetes, but to make your insulin usage more effective. Supplements like r-ALA are proven to work for this.



-Slim

ok, thanks. what other suggestions with dosages, besides r-ala. what about glucosamine and cla?

 

[Makavelli]

ok, thanks. what other suggestions with dosages, besides r-ala. what about glucosamine and cla?

Flax seed oil will improve insulin sensitivity.

 

[big_boy_1]

Glucosamine does NOT has effect on insulin sensitivity, it only works healing joints.
Metformin (Glucophage) reduces insulin sensitivity, both in muscle and fat cells.

 

[Makavelli]

Metformin (Glucophage) reduces insulin sensitivity, both in muscle and fat cells.[/QUOTE]

Where do you get that from? Glucophage slows down the digestion of food, thereby allowing the carbs to enter the bloodstream more slowly.

 

[SlimJim300]

http://www.diabetic-help.com/GLUCOPHAGE-METFORMIN .htm
137 pages on metformin's effect on insulin sensitivity.

 

[Juice Authority]

anyone know of any supplements or drugs that have been proven to reduce fat cells sensitivity to insulin? i have heard cla, glucosamine and glucorell r for this purpose, but no specific dosage recommendation if the person is currently on an insulin cycle. i had posed this question in a different thread, but i was getting lots of unrelated answers that involved treating hypoglycemia, diet, etc. thanks

Your body has a certain number of fat cells when you're born. You never lose them unless you get liposuction. Increased insulin sensitivity is not a valid approach to fat loss.

A reduction in insulin signalling = a reduction in protein synthesis = muscle loss as body-fat gets lower.