Raloxifene--Gyno

[highspeed2112]

Theres a great post a few down about the early onset of gyno and what measures should be taken..Its alittle confusing..There are those who swear by letrozole and its ability to breakdown exsiting gyno but then theres also mention of Raloxifene which MAVA recommends...Curious to know if anyone's tried this before and at what dose and thier results.

 

[georgie24]

i never tried it but MAVA is pretty witty, im going to order some to have handy and give a shot

 

[Mavafanculo]

Just going by what the available studies say.

while I know Femera - letrozole - has anecdotal buzz, last I searched (about a year ago), the only non-surgical agents that have studies showing reduction of EXISTING gynecomastia are the serms Nolvaldex - tamoxifen citrate - and raloxifene. ralox is more effective, but also more expensive and less available.

arimidex, which is an anti-a like Femera - letrozole - did nothing for reduction. great for prevention.

if anyone has studies showing Femera - letrozole - reduces xisting gynecomastia, post up. What may end up being shown is that because Femera - letrozole - is so much more effective at destroying or virtually eliminating Estrogen than arimidex , it would be effective at reducing existing gynecomastia even tho the studied anti-aromatse (arimidex) did not.



1)
Prevention and management of bicalutamide-induced gynecomastia and breast pain: randomized endocrinologic and clinical studies with tamoxifen and anastrozole.
Saltzstein D, Sieber P, Morris T, Gallo J.
Urology San Antonio Research PA, Pasteur Medical Plaza, San Antonio, Texas, USA.

A randomized, double-blind, placebo-controlled multicenter trial involving 107 men receiving bicalutamide ('Casodex') 150 mg/day therapy following radical therapy for prostate cancer assessed tamoxifen ('Nolvadex') 20 mg/day and anastrozole ('Arimidex') 1 mg/day for the prophylaxis and treatment of gynecomastia/breast pain. Tamoxifen, but not anastrozole, significantly reduced the incidence of gynecomastia/breast pain when used prophylactically and therapeutically. Serum testosterone levels increased with tamoxifen relative to placebo but prostate-specific antigen levels declined in all treatment groups. Further studies are needed to define the optimum tamoxifen dose and to assess any impact on cancer control. The use of tamoxifen in this setting remains to be investigated



2)
1: J Pediatr. 2004 Jul;145(1):71-6. Related Articles, Links

Comment in:

* J Pediatr. 2005 Apr;146(4):576; author reply 576-7.
* J Pediatr. 2005 Apr;146(4):576; author reply 576-7.

Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia.
Lawrence SE, Faught KA, Vethamuthu J, Lawson ML.
Department of Pediatrics, University of Ottawa, Ontario, Canada.

[email protected]

OBJECTIVES: To assess the efficacy of the anti-estrogens tamoxifen and raloxifene in the medical management of persistent pubertal gynecomastia.

STUDY DESIGN: Retrospective chart review of 38 consecutive patients with persistent pubertal gynecomastia who presented to a pediatric endocrinology clinic. Patients received reassurance alone or a 3- to 9-month course of an estrogen receptor modifier (tamoxifen or raloxifene).

RESULTS: Mean (SD) age of treated subjects was 14.6 (1.5) years with gynecomastia duration of 28.3 (16.4) months. Mean reduction in breast nodule diameter was 2.1 cm (95% CI 1.7, 2.7, P <.0001) after treatment with tamoxifen and 2.5 cm (95% CI 1.7, 3.3, P <.0001) with raloxifene. Some improvement was seen in 86% of patients receiving tamoxifen and in 91% receiving raloxifene, but a greater proportion had a significant decrease (>50%) with raloxifene (86%) than tamoxifen (41%). No side effects were seen in any patients.

CONCLUSION: Inhibition of estrogen receptor action in the breast appears to be safe and effective in reducing persistent pubertal gynecomastia, with a better response to raloxifene than to tamoxifen. Further study is required to determine that this is truly a treatment effect.

PMID: 15238910 [PubMed - indexed for MEDLINE]

3)
Management of physiological gynaecomastia with tamoxifen.
Khan HN, Rampaul R, Blamey RW.
Professorial Unit of Surgery, Department of Surgery, Nottingham City Hospital, Nottingham NG5 1PB, UK.

AIMS: We aimed to confirm suggestions that tamoxifen therapy alone may resolve physiological gynaecomastia. METHODS: A prospective audit of the outcome of tamoxifen routinely given to men with physiological gynaecomastia was carried out at Nottingham. Men referred with gynaecomastia had clinical signs recorded, e.g., type (diffuse 'fatty' or retro-areolar 'lump'), size and possible aetiology. They were offered oral tamoxifen 20mg once daily for 6-12 weeks. On follow-up patients were assessed for complete resolution (CR), partial resolution where patient is satisfied with outcome (PR) or no resolution (NR). Success was either CR or PR. RESULTS: Thirty-six men accepted tamoxifen for physiological gynaecomastia. Median age was 31 (range 18-64). Tenderness was present in 25 (71%) cases. Sixteen men (45%) had 'fatty' gynaecomastia and 20 had 'lump' gynaecomastia. Tamoxifen resolved the mass in 30 patients (83.3%; CR=22, PR=8) and tenderness in 21 cases (84%; CR=0, PR=0). Lump gynaecomastia was more responsive to tamoxifen than the fatty type (100% vs. 62.5%; P=0.0041). CONCLUSIONS: Oral tamoxifen is an effective treatment for physiological gynaecomastia, especially for the lump type.
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[Mavafanculo]

p.s. there's more than 1 way to skin a cat, and the absense of studies doesnt neccessarily eliminate something from consideration. If a protocol or compound starts to get consensus buzz in the BB community there's obviously something going on.

that applies to pharmaceuticals, otc's, protocols, etc

 

[Mavafanculo]

Theres a great post a few down about the early onset of gynecomastia and what measures should be taken..Its alittle confusing..There are those who swear by letrozole and its ability to breakdown exsiting gynecomastia but then theres also mention of Raloxifene which MAVA recommends...Curious to know if anyone's tried this before and at what dose and thier results.

P.S. -- if you're using nandrolones, and start to have lump gyno issues, I would try the letro as a first line treatment. Reason for letro and not serms is that there's some eveidence that nolva upregulates progesterone receptors and thats the last thing you want with nandrolones (not STRONG evidence, but a few toss off mentions in off point studies). So my thinking is if nolva does, then perhaps the whole serm class does, but thats just a better-safe-than-sorry guess.

If you have no luck with the letro, then I would suggest (in a vacuum) dropping the nandrolone compound, waiting about 10-14 days while continuing the letro and then starting the proven ralox (or nolva) protocol for reversing xisting gyno as per above.

 

[Nymuscle11]

How should i run Raloxifene? Looking to get rid of two year gyno so please help any opinion would be nice

 

[Jacob Creutzfeldt]

Anyone know in which tissues raloxifene is known to acts as an estrogen and in which tissues raloxifene acts as an estrogen blocker?

 

[Mavafanculo]

Anyone know in which tissues raloxifene is known to acts as an estrogen and in which tissues raloxifene acts as an estrogen blocker?

well, based on the studies ^^ it would act as an estrogen blocker (antagonist) in breast tissue -- and if it acts as other serms (nolva specifically) then it probably acts as an estrogen (agonist) in the liver and in bone tissue

 

[Mavafanculo]

How should i run Raloxifene? Looking to get rid of two year gyno so please help any opinion would be nice

the standard recc for gyno reversal with nolva is 80mg until symptoms abate and then taper off. I dont recall what the dose was for raloxifene.

If anyone can get full text on the study ^^ above, that would show approximate effective dose

 

[goku_kakarot77]

yo mava ,when you say existing gyno, are you talking about gyno from aas or gyno through puberty

peace