Carth, I'm not sure if it is pseudoephedrine, but some ingredient in decongestants have the nullifying effect on viagra; I'll ask my doc next time I see him. Yes, I always spray Afrin after taking a blue bullet, for me they go together. Then, later, I take Aleve for the headache. Hate the stuffiness & headache from Viagra. Another thing; if you take Viagra with or after a meal, it also doesn't work very well. Best to take it on a fairly empty stomach. Too much alchol can kill it also.