Question for Anadrol and D-bol users

[Juice Authority]

I recently posted a thread "The truth about orals". In that thread C- ditty came up with a good and interesting question that I could not answer nor could I find any information about. The question pertained to using Anadrol and D-bol together in the same cycle and whether or not that would create a receptor conflict.

C- Ditty:

"Winstrol and Fina is the most synergic cycles one can run, because they work with each other... winstrol hits receptors that fina doesn't, and fina hits receptors that winny doesn't... I'm sure you know this... but it's just an example I'm using, because I din't know how to word my question."

Dbol and Anadrol... do they hit the same receptors? I mean, anabolics attach to receptors the same way that anti-e's do... to an extent, and not the same...

Like... I wouldn't take ORAL winny and ORAL anadrol... but would take inject oral and oral anadrol... not only for the fact of the liver... but because of possible receptor interference... say... an interference that could weaken the effect of the anabolic by a certain % (what % I'm not sure).

I didn't know what the potential conflict between drol and bol would be... or if you did... that's why I asked it."

This poses a very interesting question. Does anyone have an answer to this?

Juice

 

[Citruscide]

HEEEEYYY!!!

Well, I don't know how dbol or drol work together... never even THOUGHT of trying them together until I saw the thread that was up the other day...

C-ditty

 

[satchboogie]

never even THOUGHT of trying them together until I saw the thread that was up the other day...

C-ditty

that's what i'm saying

 

[Juice Authority]

So let's hear it guys. The question is on the table. Who knows? Any references to the science would of course be appreciated.

Juice

 

[McBane]

Hey JA clean out your damn PM box lol

 

[Juice Authority]

Hey JA clean out your damn PM box lol

LOL! lately I've been getting a lot of attention, mostly negative though.

 

[Baoh]

lol

It's really quite simple. All androgenic (and directly anabolic) effects of AAS are mediated through the AR. You have more ARs than you think. You'd need to consume a very, VERY large amount to overwhelm this, and even then, there's the possibility of AR number upregulation.

There's no way there would be any kind of "interference".

Also, for the record, oral Stanazolol and Oxymetholone IS a potent stack.

 

[Juice Authority]

lol

It's really quite simple. All androgenic (and directly anabolic) effects of AAS are mediated through the AR. You have more ARs than you think. You'd need to consume a very, VERY large amount to overwhelm this, and even then, there's the possibility of AR number upregulation.

There's no way there would be any kind of "interference".

Also, for the record, oral Stanazolol and Oxymetholone IS a potent stack.

In general terms you're absolutely right. However, different types of AAS latch on to different receptors, which is the purpose behind stacking. The question posed is whether D-bol and Anadrol latch on to the same receptors nullifying the effect of each other and creating a blockage.

 

[jubei]

There is only one type of ar receptor. Also a receptor is either active or not just like a switch being on or off. Anadrol has a very poor affinity with the ar.

 

[Citruscide]

I just talked to a GURU on this issue, and here is what he came up with.

First, Dbol or Drol don't hit any sort of angrogen receptor. They don't work off that for protein synthesis... so taking 100mg dbol and 100mg drol... won't have any extra-beneficial effect...

Whereas, Fina works off the angrogen receptor... and winny doesn't... so they are actually working BETTER together... in contrast primo and fina both hit the angrogen receptor so there would be some receptor conflict.

That was what I was curious about with dbol/drol... but, apparently they don't conflict... they also, don't "work together" either.

C-ditty

 

[Baoh]

In general terms you're absolutely right. However, different types of AAS latch on to different receptors, which is the purpose behind stacking. The question posed is whether D-bol and Anadrol latch on to the same receptors nullifying the effect of each other and creating a blockage.

There's only one AR. The other receptors they attach to, such as to block glucocorticoids and such, are secondary, and have nothing to do with the AR, which is the principle means of action.

I understand the question, JA, and the answer I gave still applies.

 

[Baoh]

There is only one type of ar receptor. Also a receptor is either active or not just like a switch being on or off. Anadrol has a very poor affinity with the ar.

Yes to the first and second sentence.

Third sentence- True, but did you ever consider that much of its action could be the result of an oxymetholone metabolite?

 

[Baoh]

I just talked to a GURU on this issue, and here is what he came up with.

First, Dbol or Drol don't hit any sort of angrogen receptor. They don't work off that for protein synthesis... so taking 100mg dbol and 100mg drol... won't have any extra-beneficial effect...

Whereas, Fina works off the angrogen receptor... and winny doesn't... so they are actually working BETTER together... in contrast primo and fina both hit the angrogen receptor so there would be some receptor conflict.

That was what I was curious about with dbol/drol... but, apparently they don't conflict... they also, don't "work together" either.

C-ditty

Well, then, the GURU is mistaken.

All AAS operate primarily through the AR. Check out the study where they gave subjects methandrostenolone AND cyproterone acetate (an AR blocker). There were no substantial gains. Now, if methandrostenolone OR one of its metabolites didn't work via the AR, there would have been gains regardless of the cyproterone acetate. However, there weren't, making the point.

Stanazolol also works via the androgen receptor. However, it also has some actions that are not mediated via the AR, such as the blocking of other types of receptors, even if only weakly.

The effects of some AAS are additive, such as D-bol and Drol. However, for something like D-bol and Tren, the effect would be synergistic.

Either way, this talk of receptor conflict is baseless.



PS- If you wish to see the aforementioned study, I am pretty sure it can be found on Medline, as that's where I found it a year or two ago. I'm too lazy to look for it.

 

[Big Nipper]

LOL! lately I've been getting a lot of attention, mostly negative though.

I still love you.

 

[Citruscide]

Well, then, the GURU is mistaken.

All AAS operate primarily through the AR. Check out the study where they gave subjects methandrostenolone AND cyproterone acetate (an AR blocker). There were no substantial gains. Now, if methandrostenolone OR one of its metabolites didn't work via the AR, there would have been gains regardless of the cyproterone acetate. However, there weren't, making the point.

Stanazolol also works via the androgen receptor. However, it also has some actions that are not mediated via the AR, such as the blocking of other types of receptors, even if only weakly.

The effects of some AAS are additive, such as D-bol and Drol. However, for something like D-bol and Tren, the effect would be synergistic.

Either way, this talk of receptor conflict is baseless.



PS- If you wish to see the aforementioned study, I am pretty sure it can be found on Medline, as that's where I found it a year or two ago. I'm too lazy to look for it.

Well, I only talked to him on the phone for about a minute in passing... didn't really get toooo much into detail over it... I basically transcribed what he said.

When it comes to 'receptor conflict' -- I'm not sure of the AAS that actually have this... primo/tren to tend to attach to the same receptors... so while if you used them together, they will still be a benefit, but not as great as if stacked with something else that didn't hit the same receptors... or alone... don't know if I'm making sense...

C-ditty

 

[Baoh]

Well, I only talked to him on the phone for about a minute in passing... didn't really get toooo much into detail over it... I basically transcribed what he said.

When it comes to 'receptor conflict' -- I'm not sure of the AAS that actually have this... primo/tren to tend to attach to the same receptors... so while if you used them together, they will still be a benefit, but not as great as if stacked with something else that didn't hit the same receptors... or alone... don't know if I'm making sense...

C-ditty

Okay, listen. You keep saying things like "primo/tren do tend to attach to the same receptors". There is only one AR. All AAS attach to it. Some have poor affinity, some have high affinity. Some are in between. All, though, attach, and there are so many ARs that we non-pros should never have to worry about a point of saturation (and even that would not matter if receptor upregulation occurs). Assuming that Methenolone and Trenbolone act solely at the receptor (and, if I remember correctly, Tren has some activity at some other types of receptors, too), then they still will not conflict. They will be additive. That means it will work better. However, it will be 1+1=2 (addition), rather than -say- 1+1=2.5 or 1+1=3 (synergy).


Unless you are using several grams of both compounds, you'll never experience conflict and that is assuming there's no such thing as AR upregulation (which is still contested, but there is plenty of evidence for it).

 

[Citruscide]

ROFL -- thanks for clearing that up Boah! I don't really know that much about the area you were talking about... as I asked the original question.

C-ditty

 

[Baoh]

No problem. I was worried that I would come off like a jerk, due to the repetition.

 

[Citruscide]

No problem. I was worried that I would come off like a jerk, due to the repetition.

NO! Don't worry about that dude. It's sad to say, but I DO learn something new on here everyday, whether it be an article someone posts or whatever. I was never really CLEAR on that issue... thanks for clearing it up.

C-ditty

 

[Juice Authority]

NO! Don't worry about that dude. It's sad to say, but I DO learn something new on here everyday, whether it be an article someone posts or whatever. I was never really CLEAR on that issue... thanks for clearing it up.

C-ditty

Ditto. Good info Baoh. I learned something too. It always helps to keep an open mind. We can't know everything.

 

[Baoh]

Cool, then.

I agree, too. "Knowing 100% of anything is impossible." -Kaji