PyroGenX (my new fat burner)...

[Magick69]

I'm going to tell you guys a bit about the new Fat Burner I'm coming out with.

It's called "PyroGenX" and is part of the "Anthony Roberts" line of supplements produced by Protein Factory. If you've got any questions for me, I'd love to answer them in this thread. Omega, Nelson, Primordial, BRR, and Triceptor (Carl Lanore) have all known about this product for months now, and I've sent them all the literature, because I respect and value their opinions. All of them were blown away by the study I sent (the full version of the abstract below). It's just a damn impressive product, and when my friends and colleagues tell me that they think it's good, then I know it will be. Also...remember, this is unheard of in the supplement industry...sending a copy of your research for your next product to people who own their own supplement businesses. But I wanted good advice, so I turned to good people.

Anyway...

It primarily works by Mitochondrial Uncoupling, via UCP1 (though there is UCP2 & UCP3 action as well). Think of it like a nutritional version of dnp - dinitrophenol - - dinitrophenol - , which comes from naturally occuring sources. The primary ingredient is Fucoxanthin*. I've also added some other stuff I think is good, but you're probably only interested in the Fucoxanthin.

The dose I'm putting in PyroGenX is 500mgs/cap. And they're going to be bad ass liquid-caps, so they get totally absorbed, 100%. Anyway, in the study I have (thirty fucking bucks to buy the thing!), it shows that in the test animals, a 2% fucoxanthin rich diet (1-2 caps with each meal will get you there), the animals in the test group ended up with 15% less bodyweight and a 25% reduction in abdominal fat.

So I thought this would be a great product, contacted Protein Factory, and it's in production right now. Should be available by the end of this week or next.

Anyway, here's the abstract of the study which shows Fucoxanthin to do what I was just talking about:

Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues.
Maeda H, Hosokawa M, Sashima T, Funayama K, Miyashita K.

Laboratory of Biofunctional Material Chemistry, Division of Marine Bioscience, Graduate School of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041-8611, Japan.

Mitochondrial uncoupling protein 1 (UCP1) is usually expressed only in brown adipose tissue (BAT) and a key molecule for metabolic thermogenesis to avoid an excess of fat accumulation. However, there is little BAT in adult humans. Therefore, UCP1 expression in tissues other than BAT is expected to reduce abdominal fat. Here, we show reduction of abdominal white adipose tissue (WAT) weights in rats and mice by feeding lipids from edible seaweed, Undaria pinnatifida. Clear signals of UCP1 protein and mRNA were detected in WAT of mice fed the Undaria lipids, although there is little expression of UCP1 in WAT of mice fed control diet. The Undaria lipids mainly consisted of glycolipids and seaweed carotenoid, fucoxanthin. In the fucoxanthin-fed mice, WAT weight significantly decreased and UCP1 was clearly expressed in the WAT, while there was no difference in WAT weight and little expression of UCP1 in the glycolipids-fed mice. This result indicates that fucoxanthin upregulates the expression of UCP1 in WAT, which may contribute to reducing WAT weight.

PMID: 15896707 [PubMed - indexed for MEDLINE]

interesting....what about safety any long term studies about side effects on humans?

 

[Anthony Roberts]

Had Anthony not ran with this idea I would have included the fucoxanthin in Primordial's next fat burning product. It should workout to be good stuff…

-Pp

That's when I knew I had a winner. When people in the industry would use it themselves in their next product if I hadn't.

 

[Anthony Roberts]

Hey AR...

when will the caps be available for consumption...

A week or two. Also..there's 2 other bad ass ingredients in this stuff...just like my other products, 3 ingredients each...

 

[slimsc]

A week or two. Also..there's 2 other bad ass ingredients in this stuff...just like my other products, 3 ingredients each...

hey pro,

looks good... i am really wanting to give it a try...

 

[Magick69]

interesting....what about safety any long term studies about side effects on humans?

interesting....what about safety any long term studies about side effects on humans?

 

[INNOCENT]

sounds great...

 

[Anthony Roberts]

interesting....what about safety any long term studies about side effects on humans?

It's safe...

 

[Anthony Roberts]

The Second Ingredient In Pyrogenx!

The second ingredient in PyroGenX is Korean Pine Nut (Pinolenic Acid). At first, I resisted putting in an appetite suppressant, but then I thought that really, if you're not putting a strong stimulant into a fat burner, then you probably need some kind of appetite suppression with a Mitochondrial Uncoupler. This is because, frankly, based on my experience with them, you feel like garbage when you eat too much...sweaty, tired, hot, and miserable. SO I decided to put in Pinolenic Acid into the mix. It's a polyunsaturated fatty acid which is actually pretty healthy for you because it lowers blood pressure as well as improves cholesterol (1-2).

It Pinolenic Acid curbs your appetite by stimulating the release of the cholecystokinin (CCK) and Glucagon-Like Peptide (GLP-1), which is are hormones that tells your brain it's time to stop eating(3)...it boosts those hormones by 25% and 60%, RESPECTIVELY, FOR 4 HOURS (4)many other appetite suppressants work by antagonizing ghrelin, which will also tell your brain that you're full, but will potentially halt the release of GH as well. Pinolenic Acid has tha advantage of being very good for your blood lipids (and we know that cutting cycles often involve harsh compounds like Winny, halo, etc..)...so this should really be a home run. It's healthy and will help suppress appetite...

Although 3g of this stuff was used in the paper which examined this property of Korean Pine Nut, I didn't put that much in. Why not? Honestly, it's just too much. I don't think that that kind of dose is necessary, nor that kind of appetite suppression. Not with the Fucoxanthin already in the PyroGenX. Plus, remember...you'll likely be taking 6-12 caps a day, and that'll get you up to a level of Pinolenic acid that will provide a nice clean appetite suppression without killing your appetite completely, and making you look like you went on the Paris Hiltom diet...

Anyway, that's ingredient #2 in the PyroGenX. I'll let you know what the third (and final) ingredient is shortly.

References:

1. Sugano M, Ikeda I, Wakamatsu K, Oka T. Influence of Korean pine (Pinus koraiensis)seed oil containing cis-5,cis-9,cis-l2-octadecatrienoic acid on polyunsaturated fatty acid metabolism, eicosanoid production and blood pressure of rats. Br J Nutr. 1994 Nov;72(5):775-83.
2.. Lee JW, Lee KW, Lee SW, Kim IH, Rhee C. Selective increase in pinolenic acid (all-cis5,9,12-18:3) in Korean pine nut oil by crystallization and its effect on LDL-receptor activity. Lipids. 2004 Apr;39(4):383-7.
3. Causey JL. Korean pine nut fatty acids induce satiety-producing hormone release in overweight human volunteers. Paper presented at: American Chemical Society National Meeting & Exposition; March 26-30, 2006; Atlanta, GA. AGFD 117.
4. *Paper presentation: “Korean pine nut fatty acids affect appetite sensations, plasma CCK and GLP1 in overweight subjects,” 12:30 p.m.-3 p.m. Monday April 3, Physiology Obesity and Satiety 494.2/board #C781.

 

[jassdhali]

I'm sold on it - when are they on sale??

 

[Anthony Roberts]

Hopefully within a week or so.