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Proviron raise sperm count?
- Thread starter Mitosis
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FreakMonster
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The effect of mesterolone on sperm count, on serum follicle stimulating hormone, luteinizing hormone, plasma testosterone and outcome in idiopathic oligospermic men.
Varma TR, Patel RH.
Department of Obstetrics & Gynaecology, St. George's Hospital Medical School London, U.K.
Two hundred fifty subfertile men with idiopathic oligospermia (count less than 20 million/ml) were treated with mesterolone (100-150 mg/day) for 12 months. Seminal analysis were assayed 3 times and serum follicle stimulating hormone (FSH) luteinizing hormone (LH) and plasma testosterone were assayed once before treatment and repeated at 3, 6, 9 and 12 months after the initiation of treatment. One hundred ten patients (44%) had normal serum FSH, LH and plasma testosterone, 85 patients (34%) had low serum FSH, LH and low plasma testosterone. One hundred seventy-five patients (70%) had moderate oligospermia (count 5 to less than 20 million/ml) and 75 patients (30%) had severe oligospermia (count less than 5 million/ml). Seventy-five moderately oligospermic patients showed significant improvement in the sperm density, total sperm count and motility following mesterolone therapy whereas only 12% showed improvement in the severe oligospermic group. Mesterolone had no depressing effect on low or normal serum FSH and LH levels but had depressing effect on 25% if the levels were elevated. There was no significant adverse effect on testosterone levels or on liver function. One hundred fifteen (46%) pregnancies resulted following the treatment, 9 of 115 (7.8%) aborted and 2 (1.7%) had ectopic pregnancy. Mesterolone was found to be more useful in patients with a sperm count ranging between 5 and 20 million/ml. Those with severe oligospermia (count less than 5 million) do not seem to benefit from this therapy.
PMID: 2892728 [PubMed - indexed for MEDLINE]
Varma TR, Patel RH.
Department of Obstetrics & Gynaecology, St. George's Hospital Medical School London, U.K.
Two hundred fifty subfertile men with idiopathic oligospermia (count less than 20 million/ml) were treated with mesterolone (100-150 mg/day) for 12 months. Seminal analysis were assayed 3 times and serum follicle stimulating hormone (FSH) luteinizing hormone (LH) and plasma testosterone were assayed once before treatment and repeated at 3, 6, 9 and 12 months after the initiation of treatment. One hundred ten patients (44%) had normal serum FSH, LH and plasma testosterone, 85 patients (34%) had low serum FSH, LH and low plasma testosterone. One hundred seventy-five patients (70%) had moderate oligospermia (count 5 to less than 20 million/ml) and 75 patients (30%) had severe oligospermia (count less than 5 million/ml). Seventy-five moderately oligospermic patients showed significant improvement in the sperm density, total sperm count and motility following mesterolone therapy whereas only 12% showed improvement in the severe oligospermic group. Mesterolone had no depressing effect on low or normal serum FSH and LH levels but had depressing effect on 25% if the levels were elevated. There was no significant adverse effect on testosterone levels or on liver function. One hundred fifteen (46%) pregnancies resulted following the treatment, 9 of 115 (7.8%) aborted and 2 (1.7%) had ectopic pregnancy. Mesterolone was found to be more useful in patients with a sperm count ranging between 5 and 20 million/ml. Those with severe oligospermia (count less than 5 million) do not seem to benefit from this therapy.
PMID: 2892728 [PubMed - indexed for MEDLINE]
FreakMonster
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The effects of mesterolone on sperm count in idiopathic oligospermia.
Bhathena RK, Jassawalla MJ, Patel DN.
Forty subfertile men with idiopathic oligospermia were randomly treated with mesterolone or with placebo for more than 4 months. Seminal analysis was performed thrice before treatment, and twice after 16 weeks of treatment. There was a significant increase of semen volume (P less than .05), mean sperm concentration (P less than .01), and mean total sperm count per ejaculate (P less than .01) with mesterolone therapy. Sperm motility and morphological characteristics were not modified by mesterolone therapy. Mesterolone was found to be effective in improving the sperm concentration in mild and moderate rather than in severe idiopathic oligospermia.
Publication Types:
Clinical Trial
Randomized Controlled Trial
PMID: 2887529 [PubMed - indexed for MEDLINE]
Bhathena RK, Jassawalla MJ, Patel DN.
Forty subfertile men with idiopathic oligospermia were randomly treated with mesterolone or with placebo for more than 4 months. Seminal analysis was performed thrice before treatment, and twice after 16 weeks of treatment. There was a significant increase of semen volume (P less than .05), mean sperm concentration (P less than .01), and mean total sperm count per ejaculate (P less than .01) with mesterolone therapy. Sperm motility and morphological characteristics were not modified by mesterolone therapy. Mesterolone was found to be effective in improving the sperm concentration in mild and moderate rather than in severe idiopathic oligospermia.
Publication Types:
Clinical Trial
Randomized Controlled Trial
PMID: 2887529 [PubMed - indexed for MEDLINE]
FreakMonster
New member
The medical treatment of male infertility.
Ibrahim A, Hayat ZG.
Mesterolone, HCG and PMS, clomiphene and various other drugs were administered to 236 subfertile patients with disturbed spermatogenesis. Most of the patients received mesterolone. The effects of the various therapeutic regimes are discussed. Improvement of the sperm count and spermatozoal motility was more frequent after mesterolone treatment than after HCG and PMS or after clomiphene. 14 wives of patients in the mesterolone group became pregnant and gave birth to normal children. There were two pregnancies in the gonadotropin group and 3 in the clomiphene group. Specific treatment of the few patients with varicocele or epididymitis led to improved findings in the spermiogram.
PMID: 6666860 [PubMed - indexed for MEDLINE]
Ibrahim A, Hayat ZG.
Mesterolone, HCG and PMS, clomiphene and various other drugs were administered to 236 subfertile patients with disturbed spermatogenesis. Most of the patients received mesterolone. The effects of the various therapeutic regimes are discussed. Improvement of the sperm count and spermatozoal motility was more frequent after mesterolone treatment than after HCG and PMS or after clomiphene. 14 wives of patients in the mesterolone group became pregnant and gave birth to normal children. There were two pregnancies in the gonadotropin group and 3 in the clomiphene group. Specific treatment of the few patients with varicocele or epididymitis led to improved findings in the spermiogram.
PMID: 6666860 [PubMed - indexed for MEDLINE]
FreakMonster
New member
Combined mesterolon-clomiphene citrate therapy for treatment of oligospermia.
Bandhauer K, Meili HU.
42 subfertile patients with normal levels of plasma testerone (26 subnormal, suffering from oligospermia) have been treated with a combination of clomiphene citrate (50 mg Clomid daily) and mesterolon (50 mg Proviron daily) over a period of at least 3-6 months. The treatment resulted in pregnancy in 6 cases and in a significant improvement of the sperm count in 16. In 7, however, whilst the sperm count improved the qualitative results were unsatisfactory as many sperms were immature. Restricted spermatogenesis and a sperm count below 5 million/ml must be considered unfavourable but does not constitute a counter-indication to the combined therapy. No hazardous complications were observed.
PMID: 913461 [PubMed - indexed for MEDLINE]
Bandhauer K, Meili HU.
42 subfertile patients with normal levels of plasma testerone (26 subnormal, suffering from oligospermia) have been treated with a combination of clomiphene citrate (50 mg Clomid daily) and mesterolon (50 mg Proviron daily) over a period of at least 3-6 months. The treatment resulted in pregnancy in 6 cases and in a significant improvement of the sperm count in 16. In 7, however, whilst the sperm count improved the qualitative results were unsatisfactory as many sperms were immature. Restricted spermatogenesis and a sperm count below 5 million/ml must be considered unfavourable but does not constitute a counter-indication to the combined therapy. No hazardous complications were observed.
PMID: 913461 [PubMed - indexed for MEDLINE]
FreakMonster
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LAWNSAVER said:
Thanks
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