hairloss and gyno, are my two most susceptible sides so i have to try to work around them. Never had any SERIOUS problems yet, but dont intend to either. Acne, bloat, anxiety, libido, havent been a bit issue for me as of yet. I am most concerned with my lipids, but I have not had them tested yet, so I am shooting blind in that department. I try to take as many supps as possible when on to help with the lipids.