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speedbacker said:
Bump
PGF2a in adipose tissue in love handles?
- Thread starter bigtasty25
- Start date
Bump
speedbacker
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mm107 said:
MM- lol, yea, i'm very curious about this stuff. Hopefully doc will see this and respond. I've been looking as well and I haven't been able to find out what pgcl stands for either, it's bothering me, lol.
cipherking
New member
im intrested in this stuff. u guys seem to know alot about this. so keep talking about it. if it gets rid of fat im intrested.lol
speedbacker
New member
I'm gonna keep bumping this.
speedbacker
New member
I can't wait to guinea pig this stuff. If I wasn't bulking right now, i'd use it now. But once it's time to lean out, i'm for sure gonna pick some up.
speedbacker
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Bump for the Doc
Dr James Daemon
New member
Hi Guys-Thanks for waiting! 
Ok, Loads of new info.
Ive tried to distill it down into usable stuff- I get a headache reading studies!
mm107- this should answer your questions. The formula gives away the name!
Common name (±)-Cloprostenol sodium salt
Trade name Ciosin, Cyclix, Estrumate, Lutaprost, Onsett, Planate
Generic name Cloprostenol - sodium salt
Chemical name 1α(Z),2β(1E,3R*),3α,5α-(±)-7-2-4-(3-chlorophenoxy)-3-hydroxy-1-butenyl-3,5-dihydroxycyclopentyl-5-heptenoic acid, sodium salt
Synonym Sodium salt of (±)-(16-m-chlorophenoxy)-17,18,19,20-tetranor-PGF2α
CAS number 55028-72-3
EINECS number 259-439-3
Formula
Formula C22H28O6Cl · Na
Relative molecular weight 446.90
Transdermal use.. Im experimenting, and can tell you that it is readily, and very easily absorbed through the skin. It shows a great degree of promise as a topical product. As many of you have noted, the ability to disperse it evenly around troubled areas is going to be life changingly useful.
There are about 5 major ones in use ranging in potency, and specificity of binding.
Also, women(!) My studies have not produced any evidence to show any effects on the female reproductive system are permenant- Indeed, the drug is used to control fertility, not to end the possibility of it. The pain it seems women have is movement of the ovaries, and nothing more. The drug causes abortion by acting on the Corpus Luteum. However, the animals appear to be fit for the purpose afterwards. A farmer would be unwise to use an experimental drug and write off his prescious livestock...
But you are correct that pregnant women should n ot go near the stuff- but as a positive we can see just how effective the trandermal formula may be...
As for use on a bulking cycle- A lot of people have asked me about their "Paper weight" or how much in pounds they will put on. PGCL is not the worlds best bulking agent. Gains will be disapointing if you go by the scales. Calorie balance, eat as much as you like. Its the one time youll get away with it! It can be used on a bulking cycle- the real beauty of it is the fact that you just watch the lagging parts respond like never before.
Basically- Overall weight gain wont be anything to shout about, but the difference to biceps and calfs is extremely visible, whilst systemic fat loss is pronounced- Absorbtion through the skin is reputed (according to Pfizer) to cause systemic effects.
The only undesirable effect if used in conucntion with AAS is that the pumps become so severe that the lagging part gets so engorged that it wont travel through a full ROM unimpeded. Partial reps become the only option.
As for the evidence of permenant fat loss, I'm looking as we speak, and stumbled across this earlier:
Treatment of 3T3-L1 preadipocytes with arachidonic acid resulted in a dose-dependent inhibition of adipocyte differentiation. The cells failed to accumulate fat droplets and did not express stearoyl-CoA desaturase 1 mRNA, a marker for late-stage differentiation. The inhibition of differentiation was reversed by the addition of cyclooxygenase inhibitors ibuprofen or indomethacin. Inhibitors of the lipoxygenase and cytochrome P-450 epoxygenase pathways were unable to reverse the effect of arachidonic acid. Dexamethasone, one of the adipogenic agents normally used to induce differentiation, could be replaced with cyclooxygenase inhibitors in the differentiation cocktail. This implicated dexamethasone as a modulator of prostaglandin synthesis in culture. Prostaglandins F[2α] (ED[50] = 0.4 nM), E[2], and D[2] prevented differentiation, each with a specific, dose-dependent affinity. Prostaglandin F[2α] was the most potent inhibitor of differentiation, suggesting that a prostanoid FP[2] receptor (FP receptor) mediates the prostaglandin action. Fluprostenol (ED[50] = 0.3 nM), a selective FP receptor agonist, prevented differentiation, confirming the involvement of an FP receptor in the inhibition of 3T3-L1 preadipocyte differentiation. Stimulation of the FP receptor for 1 h during the first day of differentiation was sufficient to cause substantial inhibition. Endogenous PGF[2α] production was lower in differentiating cells compared to unstimulated preadipocytes. These data suggest that PGF[2α] production by preadipocytes plays a role in maintaining the undifferentiated state.
Hmmmmmm!
Also, here are some reports I mentioned:
----- Original Message -----
From:
> I wasn't fat but whatever body fat i did have is completly gone, my skin is paper thin and because ive been
> dosing my bies and tries only I can train indefinatly without
> fatigue. I started the correct dose and feel better. This is the
> most dramatic result I've ever seen in a few days. This is what six
> months of 5 ius a day of growth does.
==========================
From:Sent: Wednesday, March 14, 2007 7:35
i am using 50mcg per day. i do not get any pain or swelling from injection, that is good, but i get stomach cramps, no shits,sweats 15 min after inj. today i did 80-100mcgs between 2 inj. i am very lean covered in veins already using anabolics and GH , ill keep you posted, thanks
========================================================================================
>>From:To: Sent: Tuesday, March 13, 2007 2:44 AM Subject: Re: Hello.. I should be in single digit bodyfat club in 2 weeks, i love this PG-CL, thank you!!!
========================================================================================
From: To , Sent: Monday, March 12, 2007 6:59 AM ,Love the PGCL!!! I'm taking 15units 37mcg three times a day. Like this > Bicep(7.5units)/Bicep(7.5units) three times a day. No sides at all little heat and some bathroom usage but not much at all! Crazy water loss my veins are comming out like I have taking a diuretic. I'm taking AAS(steroids) with this and I'm loving it.
========================================================================================
From: To: "ip" Sent: Sunday, March 11, 2007 2:45 AM Subject:About PG-CL
INSANE PUMPS!! The only thing though is that you definitely want > to take on an empty stomach, as, if you don't, you're heading right > to the toilet. Also, I get a minor shortness of breath, but aside > from that, it's awesome! with in 5 minutes after injection I feel > warmer, some tingling in my stomach, the muscle swells up and STAYS > that way the fat is just MELTING off my body.
======================================================================================== From:To: ip Sent: Friday, March 02, 2007 9:50 AMSubject: PCGL Results So far so good. It looks like I have lost app. 10 lbs. in one week of use. I am also using HGH 1 iu per day, 2 on 1 off, and a little testosterone, app. 200 mgs. per week. My body is changing before my eyes. The side effects are very minimal, hardly noticible for me. I am mainly using my shoulders and biceps. My shoulders are getting ripped! My arms are normally 19 inches, not growing, but they are showing more definition. I started at 13% bodyfat and I will check next week to see where it is now, but I am losing fat! No doubt about it! I made 13 redijects from my first vial and will make 10 the next time. I have not tried my chest yet, do you know if it is too close the stomach to cause problems? If not I will let you know. So far this stuff seems too good to be true.
========================================================================================
----- Original Message ----- From: To: Sent: Friday, March 02, 2007 7:11 AMSubject: PGCL I would just like to say PGCL is working very well.....I can't believe how lean I'm staying and don't have to be 100% strict on my diet. It's been 2 weeks now and this is how I'm taking it.....I mix 2cc water with one amp , I take 15units (37mcg) in the morning and the same after I train. The only sides I'm getting is about 20mins after injection I must go to the restroom. My muscles are full and I'm very lean Thanks
========================================================================================
----- Original Message ----- From: To: Sent: Thursday, March 01, 2007 8:42 PM Subject: PGCL results so far.. currently this is my 2nd day using PGCL. . i've been dosing .5 ml on each opposite muscle, 3 x a day equaling 25mcg per side, agian 3 x a day. the side effects are no where near what you described. and at this rate i'll go through 1 amp in just over 3 days. day 4. as of yesterday morning after talking w. James Daemon i've increased the dose. first i added 1.05 ml of distilled water to one 500mcg amp. end result i came up with 7 syringes containing 0.15ml / 71.4mcg each. i take 3 syringes each day totaling a daily dose of 214mcg. i've also noticed a lot more results at this dosage, much compared to what robert had mention on your website, muscle hardness and vascularity, most likely from fat and water lose.. 3lbs i' have lost in the last 4 days in conjuction with a 3300 calorie contest diet and training regimen. side effects have increased slightly, nausea combinded with toliet useage. this is still very tolerable, and a damn vacation compared to 400 - 500mg of dnp a day. one thing i dont feel is any body heat increase or swelling of the injected muscle. in my opinion a 220lbs / 100kg bodybuilder could easily inject 1 amp in divided doses in about 2 days.
========================================================================================
From: To: "ip" Thursday, March 01, 2007 5:38 AM Subject: feedback on PGCL> 5 day 20mcgs 3 x day. bathroom probs nothing to worry bout .> really starting to see a difference. Where as gh bloats me.
========================================================================================
: From: To: ,Sent: Monday, February 26, 2007 7:01 AM ,Subject: pgcl : The results I'm having are more like muscle hardness and vascularity's . I did one whole amp in 6 days without anything bad............ maybe have to use the restroom more but not like I thought. U feel you need 500mcg -1mg per week to get good results. Please tell me what you think Thanks very much J
www.synergy-solutions.org
Ok, Loads of new info.
Ive tried to distill it down into usable stuff- I get a headache reading studies!
mm107- this should answer your questions. The formula gives away the name!
Common name (±)-Cloprostenol sodium salt
Trade name Ciosin, Cyclix, Estrumate, Lutaprost, Onsett, Planate
Generic name Cloprostenol - sodium salt
Chemical name 1α(Z),2β(1E,3R*),3α,5α-(±)-7-2-4-(3-chlorophenoxy)-3-hydroxy-1-butenyl-3,5-dihydroxycyclopentyl-5-heptenoic acid, sodium salt
Synonym Sodium salt of (±)-(16-m-chlorophenoxy)-17,18,19,20-tetranor-PGF2α
CAS number 55028-72-3
EINECS number 259-439-3
Formula
Formula C22H28O6Cl · Na
Relative molecular weight 446.90
Transdermal use.. Im experimenting, and can tell you that it is readily, and very easily absorbed through the skin. It shows a great degree of promise as a topical product. As many of you have noted, the ability to disperse it evenly around troubled areas is going to be life changingly useful.
There are about 5 major ones in use ranging in potency, and specificity of binding.
Also, women(!) My studies have not produced any evidence to show any effects on the female reproductive system are permenant- Indeed, the drug is used to control fertility, not to end the possibility of it. The pain it seems women have is movement of the ovaries, and nothing more. The drug causes abortion by acting on the Corpus Luteum. However, the animals appear to be fit for the purpose afterwards. A farmer would be unwise to use an experimental drug and write off his prescious livestock...
But you are correct that pregnant women should n ot go near the stuff- but as a positive we can see just how effective the trandermal formula may be...
As for use on a bulking cycle- A lot of people have asked me about their "Paper weight" or how much in pounds they will put on. PGCL is not the worlds best bulking agent. Gains will be disapointing if you go by the scales. Calorie balance, eat as much as you like. Its the one time youll get away with it! It can be used on a bulking cycle- the real beauty of it is the fact that you just watch the lagging parts respond like never before.
Basically- Overall weight gain wont be anything to shout about, but the difference to biceps and calfs is extremely visible, whilst systemic fat loss is pronounced- Absorbtion through the skin is reputed (according to Pfizer) to cause systemic effects.
The only undesirable effect if used in conucntion with AAS is that the pumps become so severe that the lagging part gets so engorged that it wont travel through a full ROM unimpeded. Partial reps become the only option.
As for the evidence of permenant fat loss, I'm looking as we speak, and stumbled across this earlier:
Treatment of 3T3-L1 preadipocytes with arachidonic acid resulted in a dose-dependent inhibition of adipocyte differentiation. The cells failed to accumulate fat droplets and did not express stearoyl-CoA desaturase 1 mRNA, a marker for late-stage differentiation. The inhibition of differentiation was reversed by the addition of cyclooxygenase inhibitors ibuprofen or indomethacin. Inhibitors of the lipoxygenase and cytochrome P-450 epoxygenase pathways were unable to reverse the effect of arachidonic acid. Dexamethasone, one of the adipogenic agents normally used to induce differentiation, could be replaced with cyclooxygenase inhibitors in the differentiation cocktail. This implicated dexamethasone as a modulator of prostaglandin synthesis in culture. Prostaglandins F[2α] (ED[50] = 0.4 nM), E[2], and D[2] prevented differentiation, each with a specific, dose-dependent affinity. Prostaglandin F[2α] was the most potent inhibitor of differentiation, suggesting that a prostanoid FP[2] receptor (FP receptor) mediates the prostaglandin action. Fluprostenol (ED[50] = 0.3 nM), a selective FP receptor agonist, prevented differentiation, confirming the involvement of an FP receptor in the inhibition of 3T3-L1 preadipocyte differentiation. Stimulation of the FP receptor for 1 h during the first day of differentiation was sufficient to cause substantial inhibition. Endogenous PGF[2α] production was lower in differentiating cells compared to unstimulated preadipocytes. These data suggest that PGF[2α] production by preadipocytes plays a role in maintaining the undifferentiated state.
Hmmmmmm!
Also, here are some reports I mentioned:
----- Original Message -----
From:
> I wasn't fat but whatever body fat i did have is completly gone, my skin is paper thin and because ive been
> dosing my bies and tries only I can train indefinatly without
> fatigue. I started the correct dose and feel better. This is the
> most dramatic result I've ever seen in a few days. This is what six
> months of 5 ius a day of growth does.
==========================
From:Sent: Wednesday, March 14, 2007 7:35
i am using 50mcg per day. i do not get any pain or swelling from injection, that is good, but i get stomach cramps, no shits,sweats 15 min after inj. today i did 80-100mcgs between 2 inj. i am very lean covered in veins already using anabolics and GH , ill keep you posted, thanks
========================================================================================
>>From:To: Sent: Tuesday, March 13, 2007 2:44 AM Subject: Re: Hello.. I should be in single digit bodyfat club in 2 weeks, i love this PG-CL, thank you!!!
========================================================================================
From: To , Sent: Monday, March 12, 2007 6:59 AM ,Love the PGCL!!! I'm taking 15units 37mcg three times a day. Like this > Bicep(7.5units)/Bicep(7.5units) three times a day. No sides at all little heat and some bathroom usage but not much at all! Crazy water loss my veins are comming out like I have taking a diuretic. I'm taking AAS(steroids) with this and I'm loving it.
========================================================================================
From: To: "ip" Sent: Sunday, March 11, 2007 2:45 AM Subject:About PG-CL
INSANE PUMPS!! The only thing though is that you definitely want > to take on an empty stomach, as, if you don't, you're heading right > to the toilet. Also, I get a minor shortness of breath, but aside > from that, it's awesome! with in 5 minutes after injection I feel > warmer, some tingling in my stomach, the muscle swells up and STAYS > that way the fat is just MELTING off my body.
======================================================================================== From:To: ip Sent: Friday, March 02, 2007 9:50 AMSubject: PCGL Results So far so good. It looks like I have lost app. 10 lbs. in one week of use. I am also using HGH 1 iu per day, 2 on 1 off, and a little testosterone, app. 200 mgs. per week. My body is changing before my eyes. The side effects are very minimal, hardly noticible for me. I am mainly using my shoulders and biceps. My shoulders are getting ripped! My arms are normally 19 inches, not growing, but they are showing more definition. I started at 13% bodyfat and I will check next week to see where it is now, but I am losing fat! No doubt about it! I made 13 redijects from my first vial and will make 10 the next time. I have not tried my chest yet, do you know if it is too close the stomach to cause problems? If not I will let you know. So far this stuff seems too good to be true.
========================================================================================
----- Original Message ----- From: To: Sent: Friday, March 02, 2007 7:11 AMSubject: PGCL I would just like to say PGCL is working very well.....I can't believe how lean I'm staying and don't have to be 100% strict on my diet. It's been 2 weeks now and this is how I'm taking it.....I mix 2cc water with one amp , I take 15units (37mcg) in the morning and the same after I train. The only sides I'm getting is about 20mins after injection I must go to the restroom. My muscles are full and I'm very lean Thanks
========================================================================================
----- Original Message ----- From: To: Sent: Thursday, March 01, 2007 8:42 PM Subject: PGCL results so far.. currently this is my 2nd day using PGCL. . i've been dosing .5 ml on each opposite muscle, 3 x a day equaling 25mcg per side, agian 3 x a day. the side effects are no where near what you described. and at this rate i'll go through 1 amp in just over 3 days. day 4. as of yesterday morning after talking w. James Daemon i've increased the dose. first i added 1.05 ml of distilled water to one 500mcg amp. end result i came up with 7 syringes containing 0.15ml / 71.4mcg each. i take 3 syringes each day totaling a daily dose of 214mcg. i've also noticed a lot more results at this dosage, much compared to what robert had mention on your website, muscle hardness and vascularity, most likely from fat and water lose.. 3lbs i' have lost in the last 4 days in conjuction with a 3300 calorie contest diet and training regimen. side effects have increased slightly, nausea combinded with toliet useage. this is still very tolerable, and a damn vacation compared to 400 - 500mg of dnp a day. one thing i dont feel is any body heat increase or swelling of the injected muscle. in my opinion a 220lbs / 100kg bodybuilder could easily inject 1 amp in divided doses in about 2 days.
========================================================================================
From: To: "ip" Thursday, March 01, 2007 5:38 AM Subject: feedback on PGCL> 5 day 20mcgs 3 x day. bathroom probs nothing to worry bout .> really starting to see a difference. Where as gh bloats me.
========================================================================================
: From: To: ,Sent: Monday, February 26, 2007 7:01 AM ,Subject: pgcl : The results I'm having are more like muscle hardness and vascularity's . I did one whole amp in 6 days without anything bad............ maybe have to use the restroom more but not like I thought. U feel you need 500mcg -1mg per week to get good results. Please tell me what you think Thanks very much J
www.synergy-solutions.org
Last edited:
speedbacker
New member
Thanks Doc. Gonna give this a shot soon.
