Pentaspan: Plasma expander

[arthus]

I can get this stuff here in Mexico. The molecular weight is 250 000 (wich means ????). I think Duchaine said that above 400 000 would not be good for competion. From what I know this stuff would work for 8-16hrs I'm not sure about that and the dosage would be 12ml/lb. And so someone weighting at 250lbs would be using 3000mL !!! Three liters? I'm not thinking in using this stuff anytime soon. But I just wanted to know what you guys know about good plasma expander not the usual glycerol stuff.
From what I've read there hasn't been any known overdosing effects. But one would be that the hematocrit would be lowered. How ever for us, that have a 55-56 hematocrit to begin with that would not represent a big problem, I wonder if adding 3 lts of this stuff would lower someone from an hematocrit of 56 to low 30s. I have no idea

 

[arthus]

bump

 

[Perry]

Mine was 57 2 weeks ago, so I wanna know too..

BUMP

 

[Deepsquat]

okay ...this is the only time you will evr hear me say to stay away from a particular drug (hell ...insulin, a-50,dnp,I say go for it)
But this is one not to mess with...it thickens your blood ,and if you become dehydrated you could die due to improper circulation...many bicycliests have died from the use of this drug....you really should ask yourself....how will this help my body building? the answer is it won't

 

[arthus]

Are we taking about the same drug here ???? Don't pentaspan actually increases the volume of blood in your system?????? Thickens it your said????? I mean, it lowers your hematocrit. Why would bicyclists use it for anyways????????? I'm saying that this drug would replace diuretics (in the day of the contest) and it would make you look better. and also it wouldn't be as dangerous (or thats what I've heard) as heavy diuresis


This is a reply from MONSTER in the AF board.

Actually it works for 12-18 hours!
The suggested doese (clinically) is below 2000mL in 24 hours or you could have plasma protien dilution and decreased hemoglobin concentration, along with affecting coagulation.
Im familiar with plasma expanders and their use in bodybuilding, but not too familiar with dosing. I actually answered because it didnt look like anyone else was gonna
But anyhow...
Molecular weight has to do with how its utilized I believe. Molecules below 40000 molecular weight are extracted by the kidneys rather quickly, and a molecular weight above (Im not sure exactly, so well go with D.D.'s number, I wouldnt argue with him ) 400000 may be utilized less eficiantly or mabye not at all.
As for no known overdosing... well, I dont think plasma expanders are used too widly, and where they are I think theyre kind of a "dirty litle secret" still. So illness and such at or after shows may be in some way attributable to them?
Symptoms of overdose or borderlining would seem to be a lot like a hypoglycemic episode with the addition of possible rebound effects.
Since its an i.v. Id be careful to have someone who knows what theyre doing administer it.

Thats about it I guess. Hopefully someone else can shed a little clearer light on this for us
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