even 1mg EOD would be fine w/ letro. i cannot believe i was doing 2.25 ED last summer. i also have shoulder problem now. i think it's from a mix of letro, into AIFM, w/ win, tren and alot of hard training and boxing. my nasty jab is what really put it over the edge when i was all dried out. i've started MSM gluc. and chon.. it helps. i recommend it highly for joints, especially if u will be fuckin around w/ anything that lowers estrogen.