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RADAR
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.Silymarin, a flavonoid extract from Milk Thistle, has been used clinically for alcoholic liver disease treatment in Europe and Asia for almost 2,000 years. Currently it?s used by bodybuilders as a protective measure for the liver when using high doses of orals.Silymarin is not water soluble and is typically administered as an encapsulated standardized extract. The absorption with oral administration is rather low, with only two to three percent being effectively taken up. The peak plasma levels after an oral dose are achieved in four to six hours. The reason this study is significant is because of the described mechanism that Milk Thistle is working in the prostate. It is showing effectiveness in treating prostate cancer because it prevents the androgen receptor from making it to the nucleus of the cell. This may be good if you are fighting cancer of the prostate, but it is bad if you are trying to get a muscle cell to grow larger.In order for testosterone to work, it must pass from the blood to the inside of a muscle cell, bind to the androgen receptor inside the cell, then travel inside the nucleus where it binds to your DNA.These researchers were able to show that Milk Thistle did not reduce the number of androgen receptors, nor did it prevent androgens (i.e., testosterone) from binding to the receptors. All it seemed to do was prevent the androgen receptor from traveling to the nucleus, and in our case, this prevents the desired effect. The androgen receptor, once bound to the androgen, must make it to the nucleus in order to increase protein synthesis.Bottom line: Use Milk Thistle if you are sure you are having liver toxicity problems. Then, only use it for a few weeks at a time. There are other herbs with tremendous hepatoprotective effects, so you might give them a try instead.
So what to do?
Only a few look at SAMe as a liver protector but this is one of the most important ones, the facts;
SAMe: The Liver Super- Nutrient
The evidence is definitely in. SAMe (S-adenosylmethionine) is serious medicine against liver disease. Almost a thousand published studies document the ability of this bioactive form of methionine to prevent and treat liver disorders, including cancer.
SAMe, the amazing "super-nutrient," can single-handedly normalize liver function. How? SAMe is the central player in liver biochemistry. It does two crucial things: It methylates, and it transforms itself into the liver's most vital substance, glutathione.
The liver contains the third highest amount of SAMe in the body, after the adrenal and pineal glands. SAMe is so important for liver function that it can be considered an essential nutrient for that organ. In addition to its many other functions, SAMe plays a leading role in liver regeneration. The liver has special SAMe enzymes just for regenerating tissue.
The liver has a tough job. It has to break down every chemical the body encounters, including drugs. It has to filter blood, chase after bacteria, make bile, and create various other substances such as lipoproteins. In short, there is a reason the liver is the only organ that readily regenerates: It has to.
SAMe is the product of a biochemical reaction between ATP and methionine. Half of all methionine in the body is used in the liver to make SAMe. SAMe has been compared to ATP in its importance for the body. It is used in many different cellular processes, from replication to biochemical reactions that create melatonin and phosphatidylcholine. SAMe is particularly important for the liver because glutathione is synthesized from it. Glutathione is crucial for liver function. A good portion of liver SAMe is turned into glutathione. Glutathione is the liver's natural antioxidant.
SAMe has been isolated from yeast and purified. It is currently sold in Europe as an antidepressant. Many clinical studies have been conducted with this supplemental form of SAMe. It has been used in trials against depression, osteoarthritis and other conditions. Of all the published studies, the ones on the liver are perhaps the most comprehensive.
The Liver Super-Nutrient
SAMe is the liver super-nutrient. Nothing comes close to providing the spectrum of health benefits that SAMe provides for the liver. Based on published clinical trials, elevating SAMe levels can have a powerful effect on many conditions. As a preventive agent, SAMe is so powerful that it can reverse the effects of chemicals and alcohol as they occur. Studies show that low SAMe levels create the conditions for liver cancer, and that SAMe can prevent these conditions from occurring. Anyone concerned about the effects of drugs, chemicals, alcohol and aging on their livers should look into the benefits of SAMe.
dosage required : 400mgs /day
2) NAC- everybody knows this one,N-acetylcysteine , which is used as a mucolytic agent in COPD and other diseases, was also found to be a powerful antioxidant, as a precursor of reduced glutathione, and a potential therapeutic agent in the treatment of diseases characterized by free radical and oxidant damage and a must have for sure,look at this study;
Patients who have had a recent heart attack, ulcerative colitis, or adult respiratory distress syndrome may be deficient in glutathione (GSH), an important protector of liver cells, red blood cells, and lymphocytes.
Lower glutathione levels in plasma and lung fluid have also been seen in patients with human immunodeficiency virus (HIV) infection. It is thought that low glutathione levels speed up the development of emphysema in HIV-positive patients, especially if they have a history of smoking. Patients who are co-infected with HIV and hepatitis C , have even further diminished levels of glutathione.
A new study by De Rosa and colleagues, published in the European Journal of Clinical Investigation, investigated the use of N-acetylcysteine , a mucolytic agent used to reduce the viscosity of mucus and to build up glutathione levels in HIV-positive patients. In an 8-week test, 31 patients received NAC and 30 received a placebo. Both groups began the study with low glutathione levels.
Results showed that the patients who received NAC had near-normal glutathione levels, whereas levels in the placebo group remained the same. No side effects were reported, although occasional dose reduction was necessary to diminish gastrointestinal effects.
To enhance all of this it is equally important to flush the system with lots of water,Cranberry Juice,and an antitoxidant such as Alpha lipotic acid.
So what to do?
Only a few look at SAMe as a liver protector but this is one of the most important ones, the facts;
SAMe: The Liver Super- Nutrient
The evidence is definitely in. SAMe (S-adenosylmethionine) is serious medicine against liver disease. Almost a thousand published studies document the ability of this bioactive form of methionine to prevent and treat liver disorders, including cancer.
SAMe, the amazing "super-nutrient," can single-handedly normalize liver function. How? SAMe is the central player in liver biochemistry. It does two crucial things: It methylates, and it transforms itself into the liver's most vital substance, glutathione.
The liver contains the third highest amount of SAMe in the body, after the adrenal and pineal glands. SAMe is so important for liver function that it can be considered an essential nutrient for that organ. In addition to its many other functions, SAMe plays a leading role in liver regeneration. The liver has special SAMe enzymes just for regenerating tissue.
The liver has a tough job. It has to break down every chemical the body encounters, including drugs. It has to filter blood, chase after bacteria, make bile, and create various other substances such as lipoproteins. In short, there is a reason the liver is the only organ that readily regenerates: It has to.
SAMe is the product of a biochemical reaction between ATP and methionine. Half of all methionine in the body is used in the liver to make SAMe. SAMe has been compared to ATP in its importance for the body. It is used in many different cellular processes, from replication to biochemical reactions that create melatonin and phosphatidylcholine. SAMe is particularly important for the liver because glutathione is synthesized from it. Glutathione is crucial for liver function. A good portion of liver SAMe is turned into glutathione. Glutathione is the liver's natural antioxidant.
SAMe has been isolated from yeast and purified. It is currently sold in Europe as an antidepressant. Many clinical studies have been conducted with this supplemental form of SAMe. It has been used in trials against depression, osteoarthritis and other conditions. Of all the published studies, the ones on the liver are perhaps the most comprehensive.
The Liver Super-Nutrient
SAMe is the liver super-nutrient. Nothing comes close to providing the spectrum of health benefits that SAMe provides for the liver. Based on published clinical trials, elevating SAMe levels can have a powerful effect on many conditions. As a preventive agent, SAMe is so powerful that it can reverse the effects of chemicals and alcohol as they occur. Studies show that low SAMe levels create the conditions for liver cancer, and that SAMe can prevent these conditions from occurring. Anyone concerned about the effects of drugs, chemicals, alcohol and aging on their livers should look into the benefits of SAMe.
dosage required : 400mgs /day
2) NAC- everybody knows this one,N-acetylcysteine , which is used as a mucolytic agent in COPD and other diseases, was also found to be a powerful antioxidant, as a precursor of reduced glutathione, and a potential therapeutic agent in the treatment of diseases characterized by free radical and oxidant damage and a must have for sure,look at this study;
Patients who have had a recent heart attack, ulcerative colitis, or adult respiratory distress syndrome may be deficient in glutathione (GSH), an important protector of liver cells, red blood cells, and lymphocytes.
Lower glutathione levels in plasma and lung fluid have also been seen in patients with human immunodeficiency virus (HIV) infection. It is thought that low glutathione levels speed up the development of emphysema in HIV-positive patients, especially if they have a history of smoking. Patients who are co-infected with HIV and hepatitis C , have even further diminished levels of glutathione.
A new study by De Rosa and colleagues, published in the European Journal of Clinical Investigation, investigated the use of N-acetylcysteine , a mucolytic agent used to reduce the viscosity of mucus and to build up glutathione levels in HIV-positive patients. In an 8-week test, 31 patients received NAC and 30 received a placebo. Both groups began the study with low glutathione levels.
Results showed that the patients who received NAC had near-normal glutathione levels, whereas levels in the placebo group remained the same. No side effects were reported, although occasional dose reduction was necessary to diminish gastrointestinal effects.
To enhance all of this it is equally important to flush the system with lots of water,Cranberry Juice,and an antitoxidant such as Alpha lipotic acid.
