Here is a study I found about how cows are given IGF-1 to increase their milk production. But it also says that healthy adults only absorb a limited amount of IGF-1. But when using NSAIDS, the intestinal absorbtion is increased.
Here's the article:
Many People are Taking IGF-1 Without Even Knowing It
Dr. Mercola's Comment:
My Associate Editor and I had the following letter published on the web site of the Western Journal of Medicine.
It was written in response to a recent Op-Ed piece (West J Med 2001;175:7-9) concerning the use of IGF-1 (insulin-like growth factor-1) by athletes, who use it to enhance their performance. Unfortunately, levels of these growth hormone and insulin mimicking substance are elevated in our milk supply, due to the use of rBGH (also known as rBST) to increase the cow's milk production.
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by Joseph Mercola, DO and Cory Mermer
Adams does an excellent job of discussing the dangers of the exogenous IGF-1, and properly cautions against its use, citing both lack of efficacy and potential adverse effects, such as disruption of the insulin system and carcinogenesis.
However, it is worth noting that much of the US population are unknowingly consuming higher levels of IGF-1 than previously and may face the same elevated risks, since it has been shown that milk from cow's treated with rBGH (Posilac) have significantly elevated IGF-1 levels. Measuring these levels has even been proposed as a basis by which to test for the use of rBGH (1).
In addition, the IGF-1 in the milk of rBGH treated cows is potentially more bioactive than the naturally occurring form and may be increased further by pasteurization (2).
While Adams notes the lack of significant effects of IGF-1 administration in elderly subjects, this certainly does not mean that this would be true for children, who may be at an increased risk of adverse effects.
Children's rapid growth rate may predispose them to be more susceptible to IGF-1. In addition, children's intestines, particularly infants, are naturally more permeable than adults, which could allow greater absorption of the large IGF-1 peptide.
While it has sometimes been assumed that IGF-1 can't be significantly absorbed when taken orally, several studies have demonstrated that this is not the case.
It was found that premature babies who were given breastmilk in addition to formula had almost double the serum IGF-1 levels of those receiving formula alone (3). This is not surprising, since breastmilk contains IGF-1 and formula does not, but it does strongly suggest intestinal absorption.
It was also demonstrated that people who consumed 3 servings of milk daily had a 10% higher serum IGF-1 level and almost a 10% lower level IGF Binding Protein 4 (IGBP-4) than those drinking less than 1-1/2 servings (4).
While IGF-1 may only be absorbed in limited quantities in healthy subjects, this is likely not be the case for those suffering from various conditions that can cause increased intestinal permeability, such as celiac disease, Crohn's disease, autism, cirrhosis, and cow's milk allergy, just to name a few.
In addition, the use of various medications, such as aspirin and other NSAIDs can increase intestinal permeability and it is estimated that 10% to 20% of the general "healthy" population suffers from this condition as well (5).
It is not enough to look at healthy adults and say that the intestinal absorption of IGF-1 is negligible. Rather, the most vulnerable in society need to be protected.
Adams eloquently points out that the use of IGF-1 for enhancing athletic performance "ignore(s) our understanding of the integrated nature of physiologic systems". However, this same ignorance was used when the FDA chose to approve rBGH.
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